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Protein |
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Gene Symbol | SGK3 to neXtProt (NX_Q96BR1) |
Description | Serine/threonine-protein kinase Sgk3 |
Chromosome | 8 |
Location | 8q13.1 (67624653 ~ 67774257) to Ensembl |
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Sequene Features : Isoforms 2, Variants 39, PTMs 4 to neXtProt Sequence Features
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Gene Ontologies |
GO: Biological Process |
GO: Mulecular Function |
GO: Cellular Component |
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.transmembrane transport .regulation of sequence-specific DNA binding transcription factor activity .regulation of cell proliferation + 5 more... |
.phosphatidylinositol binding .chloride channel regulator activity .sodium channel regulator activity + 5 more... |
.recycling endosome .cytoplasmic membrane-bounded vesicle .cytosol .early endosome |
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Proteomic Evidences |
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Release | | Protein Evidence | | Pr | | Ab | | Isoforms | | Variants | | PTMs |
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2015-01-01 | | protein level | | | | | | | 2 |
| 39 |
| 4 |
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2014-09-19 | | protein level | | | | | | | 2 |
| 31 |
| 4 |
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2014-05-27 | | protein level | | | | | | | 2 |
| 31 |
| 4 |
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2014-02-25 | | protein level | | | | | | | 2 |
| 31 |
| 4 |
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2013-12-09 | | protein level | | | | | | | 2 |
| 27 |
| 4 |
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2013-11-01 | | protein level | | | | | | | 2 |
| 27 |
| 4 |
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2013-09-12 | | protein level | | | | | | | 2 |
| 27 |
| 4 |
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2013-08-17 | | protein level | | | | | | | 2 |
| 27 |
| 4 |
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2013-07-15 | | protein level | | | | | | | 2 |
| 19 |
| 4 |
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2013-06-11 | | protein level | | | | | | | 2 |
| 19 |
| 4 |
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2013-02-12 | | protein level | | | | | | | 2 |
| 8 |
| 8 |
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2012-12-20 | | protein level | | | | | | | 2 |
| 9 |
| 8 |
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2012-10-30 | | protein level | | | | | | | 2 |
| 10 |
| 8 |
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2012-10-07 | | protein level | | | | | | | 2 |
| 10 |
| 4 |
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2012-08-24 | | protein level | | | | | | | 2 |
| 10 |
| 4 |
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2012-07-28 | | protein level | | | | | | | 2 |
| 10 |
| 4 |
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2012-06-08 | | protein level | | | | | | | 2 |
| 18 |
| 4 |
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2012-05-07 | | protein level | | | | | | | 2 |
| 15 |
| 4 |
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2012-04-10 | | protein level | | | | | | | 2 |
| 15 |
| 4 |
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2012-01-13 | | protein level | | | | | | | 2 |
| 14 |
| 4 |
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2011-12-20 | | protein level | | | | | | | 2 |
| 14 |
| 4 |
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2011-11-11 | | protein level | | | | | | | 2 |
| 14 |
| 4 |
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2011-08-23 | | protein level | | | | | | | 1 |
| 14 |
| 4 |
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Protein Isoforms |
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| : Uniquely mapped peptide | | : Gene-specific peptide | | : Shared peptide |
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Interacting Partners |
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No. |
Exp. ref. |
Symbol |
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PE |
Pr |
Ab |
Di |
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GO: Biological Process |
GO: Mulecular Function |
GO: Cellular Component |
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1 |
EBI-2801236,EBI-1564678 |
ITCH |
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.regulation of protein deubiquitination .protein K48-linked ubiquitination .protein K63-linked ubiquitination + 21 more... |
.ubiquitin protein ligase activity .CXCR chemokine receptor binding .ribonucleoprotein complex binding + 2 more... |
.extracellular exosome .cytoplasmic vesicle .membrane + 5 more... |
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EST expression level of Protein Coding Gene (ref. NCBI UniGene EST) |
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Body Sites | |
Tissues | TPM* | |
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blood | 32 | |
bone | 27 | |
bone marrow | 20 | |
brain | 32 | |
connective tissue | 20 | |
ear | 62 | |
embryonic tissue | 4 | |
eye | 19 | |
intestine | 12 | |
kidney | 28 | |
liver | 48 | |
lung | 5 | |
lymph | 22 | |
mammary gland | 46 | |
mouth | 45 | |
pancreas | 23 | |
parathyroid | 48 | |
pharynx | 24 | |
pituitary gland | 60 | |
placenta | 21 | |
prostate | 26 | |
salivary gland | 49 | |
skin | 18 | |
spleen | 56 | |
stomach | 20 | |
testis | 22 | |
thymus | 37 | |
thyroid | 42 | |
trachea | 57 | |
uterus | 12 | |
vascular | 19 | |
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Health State | |
Tissues | TPM* | |
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normal | 20 | |
breast (mammary gland) tumor | 53 | |
chondrosarcoma | 24 | |
colorectal tumor | 8 | |
gastrointestinal tumor | 16 | |
head and neck tumor | 37 | |
kidney tumor | 14 | |
liver tumor | 83 | |
lymphoma | 41 | |
non-neoplasia | 72 | |
pancreatic tumor | 19 | |
prostate cancer | 38 | |
uterine tumor | 11 | |
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Developmental Stage | |
Tissues | TPM* | |
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adult | 26 | |
embryoid body | 14 | |
neonate | 96 | |
fetus | 12 | |
juvenile | 17 | |
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TPM*: Transcripts per million; transcript expression level measured by expression sequence tags. |
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Expression level of Protein (ref. Human Protein Atlas) |
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RNA-Seq. | |
Tissues | FPKM | |
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adipose tissue | 5.2 | |
adrenal gland | 6.5 | |
appendix | 11.4 | |
bone marrow | 5.9 | |
cerebral cortex | 8.6 | |
colon | 11.6 | |
duodenum | 10 | |
esophagus | 8.4 | |
gallbladder | 10 | |
heart muscle | 4.5 | |
kidney | 13.9 | |
liver | 7.5 | |
lung | 9.3 | |
lymph node | 9.4 | |
ovary | 9.7 | |
pancreas | 7.9 | |
placenta | 5.9 | |
prostate | 7.4 | |
salivary gland | 5.7 | |
skin | 16 | |
small intestine | 11.4 | |
spleen | 9.3 | |
stomach | 8.7 | |
testis | 11.6 | |
thyroid gland | 20.1 | |
urinary bladder | 7.7 | |
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Cancer | |
Tumor | Number of patients and Staining levels | |
breast cancer | |
carcinoid | |
cervical cancer | |
colorectal cancer | |
endometrial cancer | |
glioma | |
head and neck cancer | |
liver cancer | |
lung cancer | |
lymphoma | |
melanoma | |
ovarian cancer | |
pancreatic cancer | |
prostate cancer | |
renal cancer | |
skin cancer | |
stomach cancer | |
testis cancer | |
thyroid cancer | |
urothelial cancer | |
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RNA-seq colour codes |
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Highly expressed RNAs (FPKM >50) |
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Moderately expressed RNAs (50> FPKM >10) |
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Lower expressed RNAs (10> FPKM >1) |
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The lowest expressed RNAs (FPKM value of 0 or 1) |
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Staining level colour codes |
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Highly expressed protein |
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Moderately expressed protein |
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Lower expressed protein |
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Not Detected |
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Disease |
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No. | Disease Description | Ref. |
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1 | (*607591, gene) Serum/glucocorticoid-regulated kinase-like protein; SGKL | OMIM |
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