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> Protein (NX_Q96BR9)
Protein (NX_Q96BR9)
Protein
Gene SymbolZBTB8A to neXtProt (NX_Q96BR9)
DescriptionZinc finger and BTB domain-containing protein 8A
Chromosome1
Location1p35.1 (33005028 ~ 33071540) to Ensembl
Sequene Features : Isoforms 2, Variants 39, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.regulation of transcription, DNA-templated
.transcription, DNA-templated
.metal ion binding
.DNA binding
.nucleus
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
2 39 2
2014-09-19protein level
2 27 2
2014-05-27protein level
2 27 2
2014-02-25protein level
2 26 2
2013-12-09protein level
2 19 2
2013-11-01protein level
2 19 2
2013-09-12protein level
2 19 2
2013-08-17protein level
2 19 2
2013-07-15protein level
2 13 2
2013-06-11protein level
2 13 2
2013-02-12protein level
2 10 4
2012-12-20protein level
2 11 4
2012-10-30protein level
2 11 4
2012-10-07protein level
2 11 2
2012-08-24protein level
2 11 2
2012-07-28protein level
2 11 2
2012-06-08protein level
2 12 2
2012-05-07protein level
2 11 2
2012-04-10protein level
2 11 2
2012-01-13protein level
2 6 2
2011-12-20protein level
2 6 2
2011-11-11protein level
2 6 2
2011-08-23protein level
2 6 2
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q96BR9-1
4 18 0 50109.4233
NX_Q96BR9-2
0 18 0 38319.7923
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-742740,EBI-727004 SDCBP  
  .positive regulation of extracellular exosome assembly
.positive regulation of exosomal secretion
.ephrin receptor signaling pathway
  + 9 more...
.protein N-terminus binding
.protein heterodimerization activity
.syndecan binding
  + 4 more...
.blood microparticle
.extracellular exosome
.melanosome
  + 12 more...
2 EBI-742740,EBI-744471 ZBTB24  
  .regulation of transcription, DNA-templated
.transcription, DNA-templated
.hematopoietic progenitor cell differentiation
.metal ion binding
.DNA binding
.nucleus
3 EBI-742740,EBI-348555 PIAS2  
  .negative regulation of androgen receptor signaling pathway
.positive regulation of transcription from RNA polymerase II promoter
.positive regulation of transcription, DNA-templated
  + 7 more...
.SUMO ligase activity
.androgen receptor binding
.ligase activity
  + 4 more...
.nuclear speck
.PML body
.nucleoplasm
.nucleus
4 EBI-742740,EBI-515331 YES1  
  .cellular response to peptide hormone stimulus
.leukocyte migration
.ephrin receptor signaling pathway
  + 13 more...
.ion channel binding
.enzyme binding
.ATP binding
  + 3 more...
.extracellular exosome
.extrinsic component of cytoplasmic side of plasma membrane
.focal adhesion
  + 6 more...
5 EBI-742740,EBI-744864 ZBTB48  
  .transcription, DNA-templated .metal ion binding
.sequence-specific DNA binding transcription factor activity
.DNA binding
.cytoplasm
.nucleoplasm
6 EBI-742740,EBI-351257 DDX6  
  .exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay
.cytoplasmic mRNA processing body assembly
.viral RNA genome packaging
  + 4 more...
.poly(A) RNA binding
.protein domain specific binding
.ATP binding
  + 3 more...
.intracellular membrane-bounded organelle
.RISC complex
.membrane
  + 5 more...
7 EBI-742740,EBI-358122 RPL9  
  .cellular protein metabolic process
.viral transcription
.viral life cycle
  + 8 more...
.rRNA binding
.structural constituent of ribosome
.RNA binding
.cytosolic large ribosomal subunit
.membrane
.focal adhesion
  + 5 more...
8 EBI-742740,EBI-10213071 ZNF138  
  .regulation of transcription, DNA-templated
.transcription, DNA-templated
.metal ion binding
.sequence-specific DNA binding transcription factor activity
.DNA binding
.nucleus
9 EBI-742740,EBI-1383852 PRKAA2  
  .regulation of energy homeostasis
.membrane organization
.fatty acid homeostasis
  + 31 more...
.[acetyl-CoA carboxylase] kinase activity
.[hydroxymethylglutaryl-CoA reductase (NADPH)] kinase activity
.metal ion binding
  + 7 more...
.AMP-activated protein kinase complex
.cytosol
.cytoplasm
.nucleoplasm
10 EBI-742740,EBI-746453 RAD23A  
  .positive regulation of viral genome replication
.proteasome-mediated ubiquitin-dependent protein catabolic process
.regulation of proteasomal ubiquitin-dependent protein catabolic process
  + 2 more...
.ubiquitin-specific protease binding
.polyubiquitin binding
.single-stranded DNA binding
.damaged DNA binding
.cytoplasm
.nucleoplasm
.proteasome complex
11 EBI-742740,EBI-1048159 MFAP1  
  .extracellular matrix organization .poly(A) RNA binding .extracellular region
.microfibril
12 EBI-742740,EBI-357598 PSMC1  
  .positive regulation of proteasomal protein catabolic process
.positive regulation of canonical Wnt signaling pathway
.negative regulation of canonical Wnt signaling pathway
  + 24 more...
.poly(A) RNA binding
.proteasome-activating ATPase activity
.TBP-class protein binding
  + 2 more...
.cytosolic proteasome complex
.nuclear proteasome complex
.cell junction
  + 8 more...
13 EBI-742740,EBI-358049 BYSL  
  .cell proliferation
.female pregnancy
.cell adhesion
  + 2 more...
.poly(A) RNA binding .apical part of cell
.intracellular membrane-bounded organelle
.membrane
  + 3 more...
14 EBI-742740,EBI-719941 FAM161A  
  .response to stimulus
.cilium assembly
.visual perception
.N/A .ciliary basal body
.photoreceptor connecting cilium
.centrosome
.cytoplasm
15 EBI-742740,EBI-10246152 SYT6  
  .acrosomal vesicle exocytosis
.calcium ion-dependent exocytosis of neurotransmitter
.regulation of calcium ion-dependent exocytosis
  + 2 more...
.protein homodimerization activity
.clathrin binding
.syntaxin binding
.calcium ion binding
.perinuclear endoplasmic reticulum
.synaptic vesicle membrane
.cell junction
  + 4 more...
16 EBI-742740,EBI-3919850 CDKL3  
  .dendrite extension
.positive regulation of dendrite morphogenesis
.negative regulation of axon extension
.cellular protein modification process
.ATP binding
.cyclin-dependent protein serine/threonine kinase activity
.protein kinase activity
.cytoplasm
.nucleus
17 EBI-742740,EBI-750821 ZNF276  
  .regulation of transcription, DNA-templated
.transcription, DNA-templated
.zinc ion binding
.DNA binding
.nucleus
18 EBI-742740,EBI-3439227 ZGPAT  
  .negative regulation of transcription, DNA-templated
.negative regulation of epidermal growth factor-activated receptor activity
.negative regulation of transcription from RNA polymerase II promoter
.metal ion binding
.sequence-specific DNA binding
.sequence-specific DNA binding transcription factor activity
  + 2 more...
.nucleus
19 EBI-742740,EBI-750700 EIF1AD  
  .N/A .translation initiation factor activity .intermediate filament cytoskeleton
.intracellular membrane-bounded organelle
.nucleoplasm
20 EBI-742740,EBI-740727 ZNF417  
  .regulation of transcription, DNA-templated
.transcription, DNA-templated
.metal ion binding
.DNA binding
.nucleus
21 EBI-742740,EBI-597063 ZCCHC10  
  .N/A .zinc ion binding
.nucleic acid binding
.N/A
22 EBI-742740,EBI-8637627 AEN  
  .nucleic acid phosphodiester bond hydrolysis
.intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
.response to ionizing radiation
.exonuclease activity
.nucleic acid binding
.nuclear membrane
.nucleolus
.nucleoplasm
.nucleus
23 EBI-742740,EBI-399080 KAT5  
  .positive regulation of protein acetylation
.cellular response to estradiol stimulus
.positive regulation of transcription from RNA polymerase II promoter
  + 14 more...
.repressing transcription factor binding
.androgen receptor binding
.metal ion binding
  + 2 more...
.perinuclear region of cytoplasm
.NuA4 histone acetyltransferase complex
.Piccolo NuA4 histone acetyltransferase complex
  + 6 more...
24 EBI-742740,EBI-741158 WDYHV1  
  .cellular protein modification process .protein-N-terminal glutamine amidohydrolase activity .cytosol
.nucleus
25 EBI-742740,EBI-2509913 TNIP3  
  .cellular response to lipopolysaccharide
.negative regulation of I-kappaB kinase/NF-kappaB signaling
.toll-like receptor 4 signaling pathway
  + 2 more...
.polyubiquitin binding .N/A
26 EBI-742740,EBI-2682299 ZMAT2  
  .N/A .zinc ion binding
.DNA binding
.nucleus
27 EBI-742740,EBI-6427977 ZNF587  
  .regulation of transcription, DNA-templated
.transcription, DNA-templated
.metal ion binding
.DNA binding
.nucleus
28 EBI-742740,EBI-2125614 KIFC3  
  .epithelial cell-cell adhesion
.zonula adherens maintenance
.metabolic process
  + 3 more...
.ATPase activity
.ATP binding
.microtubule motor activity
.extracellular exosome
.cytoplasmic vesicle membrane
.zonula adherens
  + 4 more...
29 EBI-742740,EBI-541426 AP1M1  
  .membrane organization
.regulation of defense response to virus by virus
.endosome to melanosome transport
  + 5 more...
.N/A .extracellular exosome
.trans-Golgi network membrane
.clathrin-coated endocytic vesicle membrane
  + 6 more...
30 EBI-742740,EBI-5666657 GPATCH2L  
  .N/A .N/A .N/A
31 EBI-742740,EBI-2843626 ARMCX1  
  .N/A .N/A .integral component of membrane
32 EBI-742740,EBI-10321972 BAZ2B  
  .regulation of transcription, DNA-templated
.transcription, DNA-templated
.zinc ion binding
.DNA binding
.nucleus
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
bladder33
blood8
bone13
brain15
connective tissue26
embryonic tissue32
eye23
heart11
intestine4
kidney23
liver19
lung14
mammary gland13
muscle18
nerve64
pancreas23
placenta3
prostate15
skin4
stomach52
testis11
thymus25
trachea19
umbilical cord72
uterus21
vascular38
Health State
TissuesTPM*
normal16
bladder carcinoma56
breast (mammary gland) tumor21
chondrosarcoma36
gastrointestinal tumor50
germ cell tumor15
kidney tumor14
liver tumor41
non-neoplasia10
primitive neuroectodermal tumor of the CNS7
prostate cancer19
retinoblastoma21
skin tumor7
soft tissue/muscle tissue tumor39
Developmental Stage
TissuesTPM*
adult17
embryoid body28
neonate32
fetus30
juvenile17
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue3.6
adrenal gland2.5
appendix1.8
cerebral cortex2.7
colon3.8
duodenum1.8
esophagus3.7
gallbladder3.4
heart muscle2
kidney2.5
liver1.5
lung3.1
ovary3.6
placenta2
prostate2.9
salivary gland1.4
skin1.1
small intestine2
spleen1.4
stomach3.1
testis2.7
thyroid gland6.2
urinary bladder4
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected


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