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> Protein (NX_Q96BY2)
Protein (NX_Q96BY2)
Protein
Gene SymbolMOAP1 to neXtProt (NX_Q96BY2)
DescriptionModulator of apoptosis 1
Chromosome14
Location14q32.12 (93648541 ~ 93651273) to Ensembl
Sequene Features : Isoforms 1, Variants 45, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.extrinsic apoptotic signaling pathway in absence of ligand
.apoptotic signaling pathway
.positive regulation of release of cytochrome c from mitochondria
  + 4 more...
.ubiquitin protein ligase binding .cytosol
.mitochondrial outer membrane
.mitochondrion
.cytoplasm
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
1 45 4
2014-09-19protein level
1 36 4
2014-05-27protein level
1 36 4
2014-02-25protein level
1 36 4
2013-12-09protein level
1 31 4
2013-11-01protein level
1 31 3
2013-09-12protein level
1 31 3
2013-08-17protein level
1 31 3
2013-07-15protein level
1 20 0
2013-06-11protein level
1 20 0
2013-02-12protein level
1 15 0
2012-12-20protein level
1 14 0
2012-10-30protein level
1 16 0
2012-10-07protein level
1 16 0
2012-08-24protein level
1 13 0
2012-07-28protein level
1 13 0
2012-06-08protein level
1 22 0
2012-05-07protein level
1 20 0
2012-04-10protein level
1 20 0
2012-01-13protein level
1 12 0
2011-12-20protein level
1 12 0
2011-11-11protein level
1 12 0
2011-08-23protein level
1 12 0
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q96BY2-1
13 0 0 39487.5674
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-739825,EBI-351018 CAMK2D  
  .negative regulation of sodium ion transmembrane transporter activity
.regulation of generation of L-type calcium current
.negative regulation of sodium ion transmembrane transport
  + 41 more...
.ion channel binding
.protein homodimerization activity
.titin binding
  + 5 more...
.perinuclear region of cytoplasm
.axon initial segment
.neuronal cell body
  + 12 more...
2 EBI-739825,EBI-1765605 THOC1  
  .negative regulation of DNA damage checkpoint
.negative regulation of isotype switching to IgA isotypes
.viral mRNA export from host cell nucleus
  + 11 more...
.RNA binding
.DNA binding
.intercellular bridge
.nuclear speck
.nuclear matrix
  + 6 more...
3 EBI-739825,EBI-10171633 PNMA5  
  .positive regulation of apoptotic process .identical protein binding .N/A
4 EBI-739825,EBI-10182361 MBIP  
  .histone H3 acetylation
.chromatin organization
.inactivation of MAPK activity involved in osmosensory signaling pathway
.identical protein binding
.protein kinase inhibitor activity
.cytoplasm
.nucleolus
.Ada2/Gcn5/Ada3 transcription activator complex
.nucleus
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adrenal gland182
ascites25
bladder200
blood106
bone13
bone marrow20
brain547
cervix41
connective tissue40
embryonic tissue18
esophagus99
eye67
heart122
intestine77
kidney313
liver14
lung80
lymph45
lymph node11
mammary gland72
mouth105
muscle47
nerve128
ovary29
pancreas18
parathyroid48
pharynx24
placenta60
prostate79
salivary gland49
skin61
spleen393
stomach167
testis27
thymus188
thyroid64
trachea173
uterus112
vascular212
Health State
TissuesTPM*
normal228
bladder carcinoma56
breast (mammary gland) tumor85
cervical tumor57
chondrosarcoma36
colorectal tumor8
esophageal tumor115
gastrointestinal tumor50
germ cell tumor132
glioma18
head and neck tumor44
kidney tumor725
leukemia42
liver tumor31
lung tumor58
lymphoma41
non-neoplasia72
ovarian tumor13
pancreatic tumor9
primitive neuroectodermal tumor of the CNS55
retinoblastoma150
skin tumor39
soft tissue/muscle tissue tumor15
uterine tumor88
Developmental Stage
TissuesTPM*
adult60
embryoid body28
blastocyst16
neonate96
fetus211
infant85
juvenile71
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue14.6
adrenal gland32.9
appendix13.9
bone marrow28
cerebral cortex94.8
colon17.4
duodenum14.6
esophagus18.5
gallbladder19.1
heart muscle46.8
kidney28.8
liver11.4
lung23.3
lymph node20
ovary18.3
pancreas10.1
placenta13.9
prostate30.8
salivary gland14.8
skin9.4
small intestine15
spleen18.1
stomach16.3
testis11.4
thyroid gland25
urinary bladder19.9
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*609485, gene) Modulator of apoptosis 1; MOAP1OMIM


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