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> Protein (NX_Q96C24)
Protein (NX_Q96C24)
Protein
Gene SymbolSYTL4 to neXtProt (NX_Q96C24)
DescriptionSynaptotagmin-like protein 4
ChromosomeX
LocationXq22.1 (99929488 ~ 99987110) to Ensembl
Sequene Features : Isoforms 2, Variants 90, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.multivesicular body sorting pathway
.positive regulation of protein secretion
.calcium ion-dependent exocytosis of neurotransmitter
  + 6 more...
.neurexin family protein binding
.clathrin binding
.syntaxin binding
  + 4 more...
.exocytic vesicle
.transport vesicle membrane
.secretory granule
  + 6 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
2 90 6
2014-09-19protein level
2 73 6
2014-05-27protein level
2 73 6
2014-02-25protein level
2 73 6
2013-12-09protein level
2 61 6
2013-11-01protein level
2 55 6
2013-09-12protein level
2 55 6
2013-08-17protein level
2 55 6
2013-07-15protein level
2 31 6
2013-06-11protein level
2 31 6
2013-02-12protein level
2 16 11
2012-12-20protein level
2 16 11
2012-10-30protein level
2 23 11
2012-10-07protein level
2 23 6
2012-08-24protein level
2 16 6
2012-07-28protein level
2 16 6
2012-06-08protein level
2 20 6
2012-05-07protein level
2 20 6
2012-04-10protein level
2 20 6
2012-01-13protein level
2 8 6
2011-12-20protein level
2 8 6
2011-11-11protein level
2 8 6
2011-08-23protein level
2 8 6
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q96C24-1
17 14 0 75975.6184
NX_Q96C24-2
2 14 0 39788.1171
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-747142,EBI-740434 ZBTB7B  
  .cell differentiation
.positive regulation of gene expression
.ectoderm development
  + 3 more...
.metal ion binding
.RNA polymerase II regulatory region sequence-specific DNA binding
.nucleoplasm
.nucleus
2 EBI-747142,EBI-740459 FXR2  
  .negative regulation of translation
.positive regulation of defense response to virus by host
.poly(A) RNA binding
.identical protein binding
.mRNA binding
.RNA binding
.extracellular exosome
.cytosolic large ribosomal subunit
.membrane
  + 3 more...
3 EBI-747142,EBI-739624 CEP70  
  .organelle organization
.mitotic cell cycle
.G2/M transition of mitotic cell cycle
.N/A .nuclear membrane
.cytosol
.centrosome
  + 2 more...
4 EBI-747142,EBI-740641 HMG20A  
  .negative regulation of neuron differentiation
.regulation of transcription, DNA-templated
.transcription, DNA-templated
  + 3 more...
.sequence-specific DNA binding transcription factor activity
.chromatin binding
.DNA binding
.nucleus
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue77
adrenal gland60
blood73
bone55
brain10
embryonic tissue4
esophagus99
eye19
heart11
intestine4
kidney9
larynx42
liver14
lung2
mammary gland13
mouth30
muscle37
ovary9
pancreas4
placenta17
prostate10
spleen37
testis9
thymus12
uterus129
vascular38
Health State
TissuesTPM*
normal17
breast (mammary gland) tumor10
chondrosarcoma36
esophageal tumor115
germ cell tumor7
glioma9
head and neck tumor22
liver tumor10
pancreatic tumor9
retinoblastoma86
soft tissue/muscle tissue tumor95
uterine tumor22
Developmental Stage
TissuesTPM*
adult15
embryoid body14
neonate32
fetus43
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue15.4
adrenal gland7.3
appendix3.5
bone marrow2.2
cerebral cortex12
colon17.6
duodenum5.1
esophagus10.1
gallbladder30.3
heart muscle6.3
kidney11.6
liver12
lung14.2
lymph node1.2
ovary82.1
pancreas5.5
placenta7.7
prostate18.7
salivary gland4.9
skin1.1
small intestine6.2
spleen8.7
stomach16.9
testis12.5
thyroid gland41.2
urinary bladder40.6
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*300723, gene) Synaptotagmin-like 4; SYTL4OMIM


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