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> Protein (NX_Q96CG3)
Protein (NX_Q96CG3)
Protein
Gene SymbolTIFA to neXtProt (NX_Q96CG3)
DescriptionTRAF-interacting protein with FHA domain-containing protein A
Chromosome4
Location4q25 (113195698 ~ 113207059) to Ensembl
Sequene Features : Isoforms 1, Variants 22, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.I-kappaB kinase/NF-kappaB signaling .N/A .N/A
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
1 22 3
2014-09-19protein level
1 16 3
2014-05-27protein level
1 16 3
2014-02-25protein level
1 16 3
2013-12-09protein level
1 14 4
2013-11-01protein level
1 14 3
2013-09-12protein level
1 14 3
2013-08-17protein level
1 14 3
2013-07-15protein level
1 9 0
2013-06-11protein level
1 9 0
2013-02-12protein level
1 8 0
2012-12-20protein level
1 8 0
2012-10-30protein level
1 8 0
2012-10-07protein level
1 8 0
2012-08-24protein level
1 6 0
2012-07-28protein level
1 6 0
2012-06-08protein level
1 9 0
2012-05-07protein level
1 9 0
2012-04-10protein level
1 9 0
2012-01-13protein level
1 4 0
2011-12-20protein level
1 4 0
2011-11-11protein level
1 4 0
2011-08-23protein level
1 4 0
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q96CG3-1
9 0 0 21431.2093
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-740711,EBI-727004 SDCBP  
  .positive regulation of extracellular exosome assembly
.positive regulation of exosomal secretion
.ephrin receptor signaling pathway
  + 9 more...
.protein N-terminus binding
.protein heterodimerization activity
.syndecan binding
  + 4 more...
.blood microparticle
.extracellular exosome
.melanosome
  + 12 more...
2 EBI-740711,EBI-1049336 TNFAIP8  
  .defense response to Gram-positive bacterium
.negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
.negative regulation of apoptotic process
.interleukin-1 beta production
.cysteine-type endopeptidase inhibitor activity involved in apoptotic process .cytoplasm
3 EBI-740711,EBI-358122 RPL9  
  .cellular protein metabolic process
.viral transcription
.viral life cycle
  + 8 more...
.rRNA binding
.structural constituent of ribosome
.RNA binding
.cytosolic large ribosomal subunit
.membrane
.focal adhesion
  + 5 more...
4 EBI-740711,EBI-355744 TRAF2  
  .positive regulation of extrinsic apoptotic signaling pathway
.regulation of extrinsic apoptotic signaling pathway via death domain receptors
.negative regulation of neuron death
  + 35 more...
.sphingolipid binding
.identical protein binding
.thioesterase binding
  + 10 more...
.IRE1-TRAF2-ASK1 complex
.TRAF2-GSTP1 complex
.membrane raft
  + 7 more...
5 EBI-740711,EBI-1606425 ZCCHC11  
  .interleukin-6-mediated signaling pathway
.positive regulation of interleukin-6 production
.negative regulation of NF-kappaB transcription factor activity
  + 7 more...
.RNA uridylyltransferase activity
.poly(A) RNA binding
.zinc ion binding
.extracellular exosome
.cytoplasm
.nucleolus
.extracellular space
6 EBI-740711,EBI-745468 ARHGEF39  
  .positive regulation of cell migration .Rho guanyl-nucleotide exchange factor activity .plasma membrane
7 EBI-740711,EBI-2932492 TXN2  
  .oxidation-reduction process
.response to axon injury
.cell redox homeostasis
  + 12 more...
.peptide-methionine (R)-S-oxide reductase activity
.oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor
.protein disulfide oxidoreductase activity
.peptide-methionine (S)-S-oxide reductase activity
.neuronal cell body
.dendrite
.mitochondrial matrix
  + 2 more...
8 EBI-740711,EBI-541426 AP1M1  
  .membrane organization
.regulation of defense response to virus by virus
.endosome to melanosome transport
  + 5 more...
.N/A .extracellular exosome
.trans-Golgi network membrane
.clathrin-coated endocytic vesicle membrane
  + 6 more...
9 EBI-740711,EBI-742426 SDCBP2  
  .intracellular transport
.intracellular signal transduction
.nervous system development
.protein heterodimerization activity
.protein homodimerization activity
.protein C-terminus binding
.extracellular exosome
.plasma membrane
.cytoplasm
10 EBI-740711,EBI-398874 NXF1  
  .poly(A)+ mRNA export from nucleus
.viral process
.gene expression
.mRNA export from nucleus
.poly(A) RNA binding
.nucleocytoplasmic transporter activity
.mRNA binding
.nucleotide binding
.nuclear inclusion body
.nuclear speck
.cytosol
  + 2 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
ascites25
blood40
bone41
bone marrow20
brain7
cervix20
connective tissue13
embryonic tissue9
eye38
heart11
intestine12
kidney28
liver9
lung17
lymph45
lymph node178
muscle9
ovary9
pancreas18
placenta28
prostate15
skin28
spleen18
stomach10
testis6
thymus25
tonsil58
trachea57
uterus38
Health State
TissuesTPM*
normal25
cervical tumor28
chondrosarcoma24
colorectal tumor17
gastrointestinal tumor8
germ cell tumor18
kidney tumor43
leukemia42
liver tumor20
lymphoma41
non-neoplasia10
pancreatic tumor9
primitive neuroectodermal tumor of the CNS7
prostate cancer9
retinoblastoma21
skin tumor15
soft tissue/muscle tissue tumor7
uterine tumor44
Developmental Stage
TissuesTPM*
adult19
embryoid body14
blastocyst16
fetus37
infant42
juvenile35
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue4.6
adrenal gland7.5
appendix20.9
bone marrow26
cerebral cortex2.9
colon7.4
duodenum7.1
esophagus17.3
gallbladder9.1
heart muscle9.6
kidney5.4
liver7.2
lung9.6
lymph node33.2
ovary9.7
pancreas20.3
placenta15.2
prostate8.8
salivary gland26.2
skin9
small intestine8.2
spleen11.4
stomach10.9
testis3.4
thyroid gland24.8
urinary bladder15.6
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*609028, gene) Traf-interacting protein with forkhead-associated domain; TIFAOMIM


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