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> Protein (NX_Q96CN9)
Protein (NX_Q96CN9)
Protein
Gene SymbolGCC1 to neXtProt (NX_Q96CN9)
DescriptionGRIP and coiled-coil domain-containing protein 1
Chromosome7
Location7q32.1 (127220672 ~ 127233665) to Ensembl
Sequene Features : Isoforms 1, Variants 100, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.protein targeting to Golgi .N/A .plasma membrane
.Golgi apparatus
.cytoplasm
.Golgi membrane
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
1 100 2
2014-09-19protein level
1 84 2
2014-05-27protein level
1 84 2
2014-02-25protein level
1 85 2
2013-12-09protein level
1 75 2
2013-11-01protein level
1 71 2
2013-09-12protein level
1 71 2
2013-08-17protein level
1 71 2
2013-07-15protein level
1 47 2
2013-06-11protein level
1 47 2
2013-02-12protein level
1 22 2
2012-12-20protein level
1 22 2
2012-10-30protein level
1 24 2
2012-10-07protein level
1 24 2
2012-08-24protein level
1 17 2
2012-07-28protein level
1 17 2
2012-06-08protein level
1 17 2
2012-05-07protein level
1 17 2
2012-04-10protein level
1 17 2
2012-01-13protein level
1 12 2
2011-12-20protein level
1 12 2
2011-11-11protein level
1 12 1
2011-08-23protein level
1 12 1
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q96CN9-1
39 0 0 87757.0528
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-746252,EBI-536879 OIP5  
  .cell division
.CENP-A containing nucleosome assembly
.cell communication
  + 2 more...
.N/A .Cajal body
.chromocenter
.cytoplasm
  + 4 more...
2 EBI-746252,EBI-308084 GLI1  
  .negative regulation of canonical Wnt signaling pathway
.notochord regression
.digestive tract morphogenesis
  + 17 more...
.metal ion binding
.transcription regulatory region DNA binding
.RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity
  + 2 more...
.ciliary base
.ciliary tip
.primary cilium
  + 5 more...
3 EBI-746252,EBI-492498 ATF4  
  .positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress
.negative regulation of oxidative stress-induced neuron death
.intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
  + 21 more...
.protein heterodimerization activity
.transcription regulatory region DNA binding
.sequence-specific DNA binding
  + 9 more...
.CHOP-ATF4 complex
.ATF1-ATF4 transcription factor complex
.ATF4-CREB1 transcription factor complex
  + 8 more...
4 EBI-746252,EBI-618309 GOLGA2  
  .negative regulation of protein binding
.mitotic cell cycle
.syntaxin binding
.protein kinase binding
.Golgi cisterna membrane
.ER to Golgi transport vesicle
.cis-Golgi network
  + 4 more...
5 EBI-746252,EBI-514538 BIRC2  
  .regulation of reactive oxygen species metabolic process
.regulation of cysteine-type endopeptidase activity
.inhibition of cysteine-type endopeptidase activity involved in apoptotic process
  + 40 more...
.protein N-terminus binding
.cysteine-type endopeptidase inhibitor activity involved in apoptotic process
.ligase activity
  + 3 more...
.membrane raft
.CD40 receptor complex
.cytoplasmic side of plasma membrane
  + 4 more...
6 EBI-746252,EBI-702370 TRIM29  
  .negative regulation of protein localization to nucleus
.transcription from RNA polymerase II promoter
.negative regulation of transcription from RNA polymerase II promoter
.zinc ion binding
.sequence-specific DNA binding transcription factor activity
.intermediate filament cytoskeleton
.cytoplasm
.nucleoplasm
7 EBI-746252,EBI-8641936 NAB2  
  .regulation of epidermis development
.myelination
.negative regulation of transcription from RNA polymerase III promoter
  + 5 more...
.transcription corepressor activity .nucleus
8 EBI-746252,EBI-2805604 KIAA0753  
  .N/A .N/A .centrosome
.cytoplasm
9 EBI-746252,EBI-946029 C1orf94  
  .N/A .N/A .N/A
10 EBI-746252,EBI-308614 CEP57  
  .protein homooligomerization
.microtubule anchoring
.fibroblast growth factor receptor signaling pathway
  + 5 more...
.protein homodimerization activity
.fibroblast growth factor binding
.microtubule cytoskeleton
.microtubule
.cytosol
  + 5 more...
11 EBI-746252,EBI-10265849 ZNF276  
  .regulation of transcription, DNA-templated
.transcription, DNA-templated
.zinc ion binding
.DNA binding
.nucleus
12 EBI-746252,EBI-10270828 NAV1  
  .neuron migration
.microtubule bundle formation
.N/A .microtubule
.cytoplasm
13 EBI-746252,EBI-739624 CEP70  
  .organelle organization
.mitotic cell cycle
.G2/M transition of mitotic cell cycle
.N/A .nuclear membrane
.cytosol
.centrosome
  + 2 more...
14 EBI-746252,EBI-3952284 DNAJA3  
  .skeletal muscle acetylcholine-gated channel clustering
.negative regulation of interferon-gamma-mediated signaling pathway
.protein stabilization
  + 23 more...
.chaperone binding
.unfolded protein binding
.NF-kappaB binding
  + 5 more...
.postsynaptic membrane
.intracellular membrane-bounded organelle
.mitochondrial nucleoid
  + 8 more...
15 EBI-746252,EBI-741037 LZTS2  
  .negative regulation of protein localization to nucleus
.negative regulation of canonical Wnt signaling pathway
.spindle midzone assembly
  + 7 more...
.N/A .midbody
.microtubule
.centrosome
.cytoplasm
16 EBI-746252,EBI-743598 ABI2  
  .positive regulation of Arp2/3 complex-mediated actin nucleation
.peptidyl-tyrosine phosphorylation
.Rac protein signal transduction
  + 5 more...
.proline-rich region binding
.protein complex binding
.ubiquitin protein ligase binding
  + 4 more...
.SCAR complex
.filopodium
.lamellipodium
  + 3 more...
17 EBI-746252,EBI-1105213 TFIP11  
  .biomineral tissue development
.RNA processing
.regulation of transcription, DNA-templated
  + 2 more...
.DNA binding .catalytic step 2 spliceosome
.U2-type post-mRNA release spliceosomal complex
.nuclear speck
  + 3 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue155
bladder33
blood16
bone27
bone marrow636
brain10
cervix20
connective tissue20
embryonic tissue9
eye9
heart22
intestine51
kidney23
larynx42
liver34
lung32
lymph45
lymph node66
mammary gland33
ovary39
placenta7
skin23
spleen74
stomach10
testis11
thyroid21
trachea19
uterus25
Health State
TissuesTPM*
normal17
breast (mammary gland) tumor21
cervical tumor28
chondrosarcoma60
colorectal tumor88
gastrointestinal tumor8
germ cell tumor15
head and neck tumor14
kidney tumor29
leukemia370
liver tumor62
lung tumor9
lymphoma41
ovarian tumor52
primitive neuroectodermal tumor of the CNS7
skin tumor31
soft tissue/muscle tissue tumor15
uterine tumor55
Developmental Stage
TissuesTPM*
adult41
embryoid body28
fetus28
juvenile53
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue5.7
adrenal gland6.2
appendix8
bone marrow8.4
cerebral cortex5.2
colon7.6
duodenum5.5
esophagus6.5
gallbladder6.9
heart muscle3.6
kidney6.8
liver5.7
lung6.9
lymph node8.4
ovary7.5
pancreas3.1
placenta7.5
prostate6.4
salivary gland6
skin6.7
small intestine5.6
spleen8.2
stomach7.1
testis16.9
thyroid gland8
urinary bladder7.9
Tissues
TissuesExpression level
adrenal glandHigh
appendixHigh
bone marrowMedium
breastHigh
bronchusHigh
cerebellumHigh
cerebral cortexMedium
cervix, uterineHigh
colonHigh
duodenumHigh
endometrium 1High
endometrium 2Medium
epididymisMedium
esophagusHigh
fallopian tubeHigh
gallbladderHigh
heart muscleMedium
hippocampusMedium
kidneyHigh
lateral ventricleHigh
liverHigh
lungMedium
lymph nodeHigh
nasopharynxHigh
oral mucosaHigh
ovaryHigh
pancreasMedium
parathyroid glandMedium
placentaHigh
prostateMedium
rectumHigh
salivary glandMedium
seminal vesicleHigh
skeletal muscleMedium
skin 1High
skin 2High
small intestineHigh
smooth muscleMedium
soft tissue 1Medium
soft tissue 2Medium
spleenHigh
stomach 1High
stomach 2High
testisHigh
thyroid glandMedium
tonsilHigh
urinary bladderMedium
vaginaHigh
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*607418, gene) Grip and coiled-coil domains-containing protein 1; GCC1OMIM


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