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> Protein (NX_Q96CS2)
Protein (NX_Q96CS2)
Protein
Gene SymbolHAUS1 to neXtProt (NX_Q96CS2)
DescriptionHAUS augmin-like complex subunit 1
Chromosome18
Location18q21.1 (43684298 ~ 43708299) to Ensembl
Sequene Features : Isoforms 2, Variants 38, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.cell division
.centrosome organization
.spindle assembly
.mitotic nuclear division
.N/A .HAUS complex
.microtubule
.centrosome
  + 2 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
2 38 4
2014-09-19protein level
2 28 4
2014-05-27protein level
2 28 4
2014-02-25protein level
2 28 4
2013-12-09protein level
2 22 4
2013-11-01protein level
2 22 4
2013-09-12protein level
2 22 4
2013-08-17protein level
2 22 4
2013-07-15protein level
2 14 0
2013-06-11protein level
2 14 0
2013-02-12protein level
2 9 0
2012-12-20protein level
2 9 0
2012-10-30protein level
2 9 0
2012-10-07protein level
2 9 0
2012-08-24protein level
2 9 0
2012-07-28protein level
2 9 0
2012-06-08protein level
2 9 0
2012-05-07protein level
2 7 0
2012-04-10protein level
2 7 0
2012-01-13protein level
2 5 0
2011-12-20protein level
2 5 0
2011-11-11protein level
2 5 0
2011-08-23protein level
2 5 0
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q96CS2-1
6 8 0 31843.4964
NX_Q96CS2-2
1 8 0 22729.8698
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-2514791,EBI-10283466 SYCE3  
  .cell division
.positive regulation of apoptotic process
.spermatogenesis
  + 2 more...
.N/A .chromosome
.nucleus
.central element
2 EBI-2514791,EBI-715849 NDC80  
  .attachment of mitotic spindle microtubules to kinetochore
.cell division
.attachment of spindle microtubules to kinetochore
  + 7 more...
.identical protein binding
.structural constituent of cytoskeleton
.Ndc80 complex
.membrane
.cytosol
  + 5 more...
3 EBI-2514791,EBI-745127 IFIT3  
  .type I interferon signaling pathway
.defense response to virus
.negative regulation of apoptotic process
  + 4 more...
.identical protein binding .cytosol
.mitochondrion
.cytoplasm
4 EBI-2514791,EBI-710124 KDM1A  
  .positive regulation of stem cell proliferation
.positive regulation of neural precursor cell proliferation
.negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
  + 27 more...
.androgen receptor binding
.flavin adenine dinucleotide binding
.transcription regulatory region DNA binding
  + 13 more...
.transcription factor complex
.nucleoplasm
.nucleus
.nuclear chromatin
5 EBI-2514791,EBI-714135 STX11  
  .membrane fusion
.vesicle docking
.natural killer cell degranulation
  + 4 more...
.SNAP receptor activity
.SNARE binding
.SNARE complex
.integral component of membrane
.endomembrane system
  + 3 more...
6 EBI-2514791,EBI-1047263 KRT38  
  .N/A .structural molecule activity .extracellular exosome
.intermediate filament
7 EBI-2514791,EBI-740738 LDOC1  
  .negative regulation of cell proliferation .N/A .nucleolus
.nucleus
8 EBI-2514791,EBI-297888 KRT18  
  .hepatocyte apoptotic process
.extrinsic apoptotic signaling pathway
.intermediate filament cytoskeleton organization
  + 6 more...
.scaffold protein binding
.poly(A) RNA binding
.structural molecule activity
.cell periphery
.extracellular exosome
.perinuclear region of cytoplasm
  + 6 more...
9 EBI-2514791,EBI-742756 KRT19  
  .cell differentiation involved in embryonic placenta development
.sarcomere organization
.response to estrogen
.viral process
.structural constituent of muscle
.structural constituent of cytoskeleton
.cell periphery
.extracellular exosome
.costamere
  + 5 more...
10 EBI-2514791,EBI-295827 DMD  
  .positive regulation of sodium ion transmembrane transporter activity
.negative regulation of peptidyl-cysteine S-nitrosylation
.regulation of voltage-gated calcium channel activity
  + 23 more...
.nitric-oxide synthase binding
.vinculin binding
.myosin binding
  + 5 more...
.postsynaptic membrane
.synapse
.membrane raft
  + 15 more...
11 EBI-2514791,EBI-719493 TRIM27  
  .negative regulation of viral release from host cell
.negative regulation of interleukin-2 secretion
.negative regulation of calcium ion import
  + 17 more...
.metal ion binding
.ligase activity
.zinc ion binding
  + 4 more...
.nuclear membrane
.PML body
.membrane
  + 6 more...
12 EBI-2514791,EBI-739566 KRT15  
  .activation of mitophagy in response to mitochondrial depolarization
.epidermis development
.scaffold protein binding
.structural constituent of cytoskeleton
.extracellular exosome
.intermediate filament
.nucleus
13 EBI-2514791,EBI-740098 TRIM23  
  .positive regulation of catalytic activity
.protein ubiquitination
.viral process
.small GTPase mediated signal transduction
.identical protein binding
.GDP binding
.ligase activity
  + 5 more...
.extracellular exosome
.lysosomal membrane
.nucleus
.Golgi membrane
14 EBI-2514791,EBI-347978 NUP62  
  .regulation of cellular response to heat
.transmembrane transport
.mRNA transport
  + 34 more...
.thyroid hormone receptor binding
.ubiquitin binding
.SH2 domain binding
  + 3 more...
.Flemming body
.pore complex
.intracellular membrane-bounded organelle
  + 7 more...
15 EBI-2514791,EBI-1045155 MAGEA6  
  .N/A .N/A .N/A
16 EBI-2514791,EBI-638194 ARFIP2  
  .regulation of Arp2/3 complex-mediated actin nucleation
.ruffle organization
.actin cytoskeleton organization
  + 3 more...
.phosphatidylinositol-4-phosphate binding
.Rac GTPase binding
.GTP-dependent protein binding
.GTP binding
.trans-Golgi network membrane
.cell cortex
.plasma membrane
  + 2 more...
17 EBI-2514791,EBI-1181367 CDR2  
  .N/A .N/A .cytoplasm
18 EBI-2514791,EBI-618309 GOLGA2  
  .negative regulation of protein binding
.mitotic cell cycle
.syntaxin binding
.protein kinase binding
.Golgi cisterna membrane
.ER to Golgi transport vesicle
.cis-Golgi network
  + 4 more...
19 EBI-2514791,EBI-6509505 INCA1  
  .positive regulation of apoptotic signaling pathway
.negative regulation of cyclin-dependent protein serine/threonine kinase activity
.negative regulation of cell proliferation
.cyclin binding
.cyclin-dependent protein serine/threonine kinase inhibitor activity
.cytoplasm
.nucleus
20 EBI-2514791,EBI-359224 TRAF1  
  .regulation of extrinsic apoptotic signaling pathway
.positive regulation of NF-kappaB transcription factor activity
.signal transduction
  + 2 more...
.thioesterase binding
.ubiquitin protein ligase binding
.zinc ion binding
.tumor necrosis factor receptor binding
.cytoplasm
21 EBI-2514791,EBI-715074 DCTN2  
  .melanosome transport
.antigen processing and presentation of exogenous peptide antigen via MHC class II
.cell proliferation
  + 5 more...
.spectrin binding
.motor activity
.extracellular exosome
.vesicle
.growth cone
  + 8 more...
22 EBI-2514791,EBI-948001 KRT31  
  .epidermis development .structural constituent of cytoskeleton .extracellular exosome
.intermediate filament
.extracellular space
23 EBI-2514791,EBI-2808286 CCDC57  
  .N/A .N/A .N/A
24 EBI-2514791,EBI-742948 MTUS2  
  .N/A .protein homodimerization activity
.microtubule binding
.microtubule
.cytoplasm
.nucleus
25 EBI-2514791,EBI-1105124 PDE4DIP  
  .cellular protein complex assembly .enzyme binding .myofibril
.centrosome
.Golgi apparatus
  + 2 more...
26 EBI-2514791,EBI-10171697 KRT40  
  .N/A .structural molecule activity .intermediate filament
27 EBI-2514791,EBI-2837036 C3orf62  
  .N/A .N/A .N/A
28 EBI-2514791,EBI-741048 NUP54  
  .regulation of cellular response to heat
.transmembrane transport
.mRNA transport
  + 17 more...
.nucleocytoplasmic transporter activity .nuclear membrane
.cytoplasm
.nucleoplasm
  + 2 more...
29 EBI-2514791,EBI-749955 TRIM69  
  .apoptotic process .ligase activity
.zinc ion binding
.ubiquitin-protein transferase activity
.nuclear speck
.plasma membrane
.cytoplasm
.nucleus
30 EBI-2514791,EBI-744203 IFT20  
  .regulation of autophagic vacuole assembly
.regulation of cilium assembly
.protein localization to cilium
  + 13 more...
.N/A .ciliary base
.ciliary tip
.primary cilium
  + 13 more...
31 EBI-2514791,EBI-10181988 CEP57L1  
  .microtubule anchoring .N/A .microtubule
.microtubule organizing center
.cytoplasm
32 EBI-2514791,EBI-6872807 SYCE1  
  .cell division
.synaptonemal complex assembly
.N/A .central element
33 EBI-2514791,EBI-2799833 VPS52  
  .embryonic ectodermal digestive tract development
.protein transport
.ectodermal cell differentiation
.syntaxin binding .perinuclear region of cytoplasm
.endosome membrane
.Golgi apparatus
34 EBI-2514791,EBI-739895 USHBP1  
  .N/A .PDZ domain binding .N/A
35 EBI-2514791,EBI-741724 SPERT  
  .N/A .N/A .cytoplasmic membrane-bounded vesicle
36 EBI-2514791,EBI-739624 CEP70  
  .organelle organization
.mitotic cell cycle
.G2/M transition of mitotic cell cycle
.N/A .nuclear membrane
.cytosol
.centrosome
  + 2 more...
37 EBI-2514791,EBI-10196469 CAGE1  
  .N/A .N/A .N/A
38 EBI-2514791,EBI-2548751 MIPOL1  
  .N/A .N/A .nucleus
39 EBI-2514791,EBI-10175300 CCHCR1  
  .cell differentiation
.multicellular organismal development
.protein export from nucleus
.N/A .centriole
.cytoplasm
.nucleus
40 EBI-2514791,EBI-465804 DTNBP1  
  .membrane organization
.regulation of dopamine receptor signaling pathway
.platelet dense granule organization
  + 11 more...
.N/A .postsynaptic membrane
.dendritic spine
.neuron projection
  + 14 more...
41 EBI-2514791,EBI-10171416 CCDC136  
  .N/A .N/A .integral component of membrane
.mitochondrion
42 EBI-2514791,EBI-743488 CEP170P1  
  .N/A .identical protein binding .N/A
43 EBI-2514791,EBI-741355 LURAP1  
  .positive regulation of I-kappaB kinase/NF-kappaB signaling
.actomyosin structure organization
.cell migration
.positive regulation of cytokine production
.N/A .actomyosin
.cytoplasm
44 EBI-2514791,EBI-10173858 CCDC114  
  .outer dynein arm assembly .N/A .outer dynein arm
.cilium
45 EBI-2514791,EBI-8466265 AK8  
  .ventricular system development
.nucleoside triphosphate biosynthetic process
.nucleoside diphosphate phosphorylation
.ATP binding
.nucleoside diphosphate kinase activity
.cytidylate kinase activity
.adenylate kinase activity
.cytosol
46 EBI-2514791,EBI-741977 CEP63  
  .cell division
.spindle assembly
.signal transduction in response to DNA damage
  + 6 more...
.N/A .cytosol
.centriole
.centrosome
.spindle pole
47 EBI-2514791,EBI-413317 SPAG5  
  .regulation of attachment of spindle microtubules to kinetochore
.cell division
.chromosome segregation
  + 2 more...
.N/A .mitotic spindle
.microtubule plus-end
.midbody
  + 7 more...
48 EBI-2514791,EBI-346882 TSG101  
  .positive regulation of viral budding via host ESCRT complex
.regulation of viral budding via host ESCRT complex
.regulation of extracellular exosome assembly
  + 21 more...
.calcium-dependent protein binding
.virion binding
.ubiquitin binding
  + 4 more...
.extracellular exosome
.late endosome membrane
.endosome membrane
  + 8 more...
49 EBI-2514791,EBI-739657 KXD1  
  .vesicle-mediated transport .N/A .BLOC-1 complex
50 EBI-2514791,EBI-2125614 KIFC3  
  .epithelial cell-cell adhesion
.zonula adherens maintenance
.metabolic process
  + 3 more...
.ATPase activity
.ATP binding
.microtubule motor activity
.extracellular exosome
.cytoplasmic vesicle membrane
.zonula adherens
  + 4 more...
51 EBI-2514791,EBI-2130429 TRIM54  
  .cell differentiation
.multicellular organismal development
.signal transduction
  + 2 more...
.zinc ion binding
.signal transducer activity
.Z disc
.microtubule associated complex
.microtubule
52 EBI-2514791,EBI-744115 CEP44  
  .N/A .N/A .midbody
.centrosome
.cytoplasm
.spindle pole
53 EBI-2514791,EBI-394607 MED4  
  .positive regulation of transcription, DNA-templated
.androgen receptor signaling pathway
.intracellular steroid hormone receptor signaling pathway
  + 3 more...
.thyroid hormone receptor binding
.vitamin D receptor binding
.ligand-dependent nuclear receptor transcription coactivator activity
  + 3 more...
.mediator complex
.membrane
.nucleoplasm
.nucleus
54 EBI-2514791,EBI-1104764 FGFR1OP2  
  .wound healing .N/A .cytosol
55 EBI-2514791,EBI-1105213 TFIP11  
  .biomineral tissue development
.RNA processing
.regulation of transcription, DNA-templated
  + 2 more...
.DNA binding .catalytic step 2 spliceosome
.U2-type post-mRNA release spliceosomal complex
.nuclear speck
  + 3 more...
56 EBI-2514791,EBI-465781 BLOC1S6  
  .membrane fusion
.membrane organization
.positive regulation of pigment cell differentiation
  + 12 more...
.actin filament binding
.protein homodimerization activity
.identical protein binding
.syntaxin binding
.BLOC-1 complex
.transport vesicle
.extrinsic component of membrane
  + 4 more...
57 EBI-2514791,EBI-719716 NINL  
  .organelle organization
.mitotic cell cycle
.G2/M transition of mitotic cell cycle
.calcium ion binding .microtubule
.cytosol
.microtubule organizing center
58 EBI-2514791,EBI-712969 CCDC53  
  .protein transport .N/A .WASH complex
.intracellular membrane-bounded organelle
.actin cytoskeleton
.early endosome
59 EBI-2514791,EBI-742610 MAD1L1  
  .regulation of metaphase plate congression
.cell division
.small GTPase mediated signal transduction
  + 4 more...
.N/A .mitotic spindle
.actin cytoskeleton
.cytosol
  + 6 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adrenal gland30
ascites25
blood65
bone69
bone marrow102
brain11
cervix41
connective tissue100
embryonic tissue18
eye311
heart22
intestine34
kidney18
liver14
lung26
lymph45
lymph node66
mammary gland19
mouth15
muscle47
nerve128
ovary49
pancreas51
parathyroid242
pharynx24
placenta63
prostate10
salivary gland98
skin9
stomach20
testis11
thymus50
uterus34
Health State
TissuesTPM*
normal31
breast (mammary gland) tumor21
chondrosarcoma36
colorectal tumor35
gastrointestinal tumor25
germ cell tumor18
glioma27
kidney tumor14
leukemia42
lung tumor9
lymphoma55
non-neoplasia31
ovarian tumor52
pancreatic tumor85
primitive neuroectodermal tumor of the CNS7
prostate cancer19
retinoblastoma1292
skin tumor7
soft tissue/muscle tissue tumor167
Developmental Stage
TissuesTPM*
adult40
embryoid body42
blastocyst16
fetus34
juvenile35
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue8.9
adrenal gland10.5
appendix17.2
bone marrow21.4
cerebral cortex5.3
colon15.4
duodenum11.8
esophagus11.7
gallbladder14.2
heart muscle7.4
kidney10.8
liver6.3
lung10.3
lymph node27.2
ovary21.9
pancreas5.2
placenta14.5
prostate9.4
salivary gland4.7
skin8.5
small intestine12.1
spleen12.1
stomach11.2
testis12.7
thyroid gland12.3
urinary bladder19
Tissues
TissuesExpression level
adrenal glandMedium
appendixMedium
bone marrowMedium
breastMedium
bronchusHigh
cerebellumMedium
cerebral cortexMedium
cervix, uterineMedium
colonMedium
duodenumMedium
endometrium 1Medium
endometrium 2Medium
epididymisMedium
esophagusHigh
fallopian tubeMedium
gallbladderHigh
heart muscleMedium
hippocampusLow
kidneyMedium
lateral ventricleLow
liverMedium
lungMedium
lymph nodeLow
nasopharynxHigh
oral mucosaMedium
pancreasMedium
parathyroid glandMedium
placentaMedium
prostateMedium
rectumMedium
salivary glandMedium
seminal vesicleMedium
skeletal muscleMedium
skin 1Low
skin 2Low
small intestineMedium
smooth muscleLow
soft tissue 1Medium
soft tissue 2Medium
spleenLow
stomach 1Medium
stomach 2Medium
testisHigh
thyroid glandMedium
tonsilMedium
urinary bladderMedium
vaginaMedium
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*608775, gene) Haus augmin-like complex, subunit 1; HAUS1OMIM


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