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> Protein (NX_Q96CS7)
Protein (NX_Q96CS7)
Protein
Gene SymbolPLEKHB2 to neXtProt (NX_Q96CS7)
DescriptionPleckstrin homology domain-containing family B member 2
Chromosome2
Location2q21.1 (131862420 ~ 132111282) to Ensembl
Sequene Features : Isoforms 6, Variants 51, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.N/A .N/A .recycling endosome membrane
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
6 51 1
2014-09-19protein level
6 37 1
2014-05-27protein level
6 33 1
2014-02-25protein level
6 32 1
2013-12-09protein level
6 29 1
2013-11-01protein level
6 28 1
2013-09-12protein level
6 28 1
2013-08-17protein level
6 28 1
2013-07-15protein level
5 17 0
2013-06-11protein level
5 17 0
2013-02-12protein level
5 10 0
2012-12-20protein level
3 7 0
2012-10-30protein level
3 8 0
2012-10-07protein level
3 8 0
2012-08-24protein level
3 6 0
2012-07-28protein level
3 7 0
2012-06-08protein level
3 8 0
2012-05-07protein level
3 6 0
2012-04-10protein level
3 6 0
2012-01-13protein level
3 5 0
2011-12-20protein level
3 5 0
2011-11-11protein level
3 5 0
2011-08-23protein level
3 5 0
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q96CS7-1
1 6 0 24719.7942
NX_Q96CS7-2
11 5 0 34132.4654
NX_Q96CS7-3
1 6 0 24591.736
NX_Q96CS7-4
2 5 0 19838.4659
NX_Q96CS7-5
1 6 0 20361.5787
NX_Q96CS7-6
2 6 0 25574.2889
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-373552,EBI-711810 BHLHE40  
  .negative regulation of transcription, DNA-templated
.negative regulation of sequence-specific DNA binding transcription factor activity
.entrainment of circadian clock by photoperiod
  + 4 more...
.E-box binding
.protein heterodimerization activity
.MRF binding
  + 10 more...
.Golgi apparatus
.nucleolus
.nucleoplasm
.nucleus
2 EBI-373552,EBI-373258 STAM2  
  .membrane organization
.negative regulation of epidermal growth factor receptor signaling pathway
.endosomal transport
  + 2 more...
.N/A .intracellular membrane-bounded organelle
.early endosome membrane
.cytosol
  + 2 more...
3 EBI-373552,EBI-9250559 CDA  
  .nucleobase-containing small molecule metabolic process
.protein homotetramerization
.negative regulation of nucleotide metabolic process
  + 8 more...
.protein homodimerization activity
.zinc ion binding
.cytidine deaminase activity
.nucleoside binding
.cytosol
.extracellular region
4 EBI-373552,EBI-724310 DAZAP2  
  .N/A .WW domain binding .cytoplasm
.nucleus
5 EBI-373552,EBI-946029 C1orf94  
  .N/A .N/A .N/A
6 EBI-373552,EBI-713198 EPN1  
  .embryonic organ development
.negative regulation of epidermal growth factor receptor signaling pathway
.female pregnancy
  + 4 more...
.lipid binding .coated pit
.plasma membrane
.cytoplasm
.nucleus
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue77
adrenal gland242
ascites100
blood106
bone55
bone marrow20
brain290
cervix61
connective tissue167
embryonic tissue89
esophagus99
eye95
heart89
intestine120
kidney156
liver199
lung59
lymph22
lymph node66
mammary gland85
mouth120
muscle56
nerve64
ovary19
pancreas46
placenta14
prostate10
skin28
stomach20
testis16
trachea19
uterus12
Health State
TissuesTPM*
normal143
adrenal tumor158
breast (mammary gland) tumor128
cervical tumor28
chondrosarcoma84
colorectal tumor151
esophageal tumor115
gastrointestinal tumor126
germ cell tumor262
glioma149
head and neck tumor119
kidney tumor145
leukemia42
liver tumor208
lung tumor29
lymphoma41
non-neoplasia310
ovarian tumor65
pancreatic tumor95
primitive neuroectodermal tumor of the CNS220
prostate cancer182
retinoblastoma150
skin tumor103
soft tissue/muscle tissue tumor79
uterine tumor110
Developmental Stage
TissuesTPM*
adult104
embryoid body142
blastocyst130
neonate128
fetus52
infant850
juvenile107
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue23.7
adrenal gland52.1
appendix39.4
bone marrow38.4
cerebral cortex70.7
colon62.1
duodenum42
esophagus23.8
gallbladder32.5
heart muscle26.4
kidney98.8
liver9.8
lung39.5
lymph node35.8
ovary10.7
pancreas9.3
placenta30.5
prostate31.9
salivary gland19.2
skin18
small intestine50.5
spleen38
stomach48.9
testis42.4
thyroid gland50.4
urinary bladder39.6
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)


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