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> Protein (NX_Q96CV9)
Protein (NX_Q96CV9)
Protein
Gene SymbolOPTN to neXtProt (NX_Q96CV9)
DescriptionOptineurin
Chromosome10
Location10p13 (13141449 ~ 13180291) to Ensembl
Sequene Features : Isoforms 3, Variants 70, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.Golgi ribbon formation
.defense response to Gram-negative bacterium
.negative regulation of I-kappaB kinase/NF-kappaB signaling
  + 10 more...
.K63-linked polyubiquitin binding
.identical protein binding
.polyubiquitin binding
  + 2 more...
.recycling endosome
.perinuclear region of cytoplasm
.cytoplasmic membrane-bounded vesicle
  + 8 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
3 70 8
2014-09-19protein level
3 60 8
2014-05-27protein level
3 60 8
2014-02-25protein level
3 60 8
2013-12-09protein level
3 48 8
2013-11-01protein level
3 46 7
2013-09-12protein level
3 46 7
2013-08-17protein level
3 46 7
2013-07-15protein level
3 39 7
2013-06-11protein level
3 39 7
2013-02-12protein level
3 21 21
2012-12-20protein level
3 20 21
2012-10-30protein level
3 26 21
2012-10-07protein level
3 26 7
2012-08-24protein level
3 26 7
2012-07-28protein level
3 26 7
2012-06-08protein level
3 28 7
2012-05-07protein level
3 23 7
2012-04-10protein level
3 23 7
2012-01-13protein level
3 17 7
2011-12-20protein level
3 17 7
2011-11-11protein level
3 17 6
2011-08-23protein level
3 17 6
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q96CV9-1
0 29 0 65880.0366
NX_Q96CV9-2
1 28 0 65161.6262
NX_Q96CV9-3
0 26 0 59522.0285
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-748974,EBI-2799016 DYSF  
  .vesicle fusion
.plasma membrane repair
.calcium-dependent phospholipid binding
.phospholipid binding
.calcium ion binding
.extracellular exosome
.sarcolemma
.cytoplasmic vesicle membrane
  + 8 more...
2 EBI-748974,EBI-981819 VWF  
  .protein homooligomerization
.cell-substrate adhesion
.extracellular matrix organization
  + 9 more...
.chaperone binding
.protein N-terminus binding
.protein homodimerization activity
  + 6 more...
.extracellular exosome
.Weibel-Palade body
.platelet alpha granule lumen
  + 6 more...
3 EBI-748974,EBI-466029 HTT  
  .negative regulation of extrinsic apoptotic signaling pathway
.iron ion homeostasis
.L-glutamate import
  + 38 more...
.diazepam binding
.beta-tubulin binding
.dynein intermediate chain binding
  + 6 more...
.protein complex
.cytoplasmic vesicle membrane
.dendrite
  + 11 more...
4 EBI-748974,EBI-9819090 NRL  
  .response to stimulus
.retinal rod cell development
.positive regulation of transcription from RNA polymerase II promoter
  + 4 more...
.leucine zipper domain binding
.DNA binding
.RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
.RNA polymerase II core promoter proximal region sequence-specific DNA binding
.nucleus
5 EBI-748974,EBI-722293 RAB8A  
  .protein localization to plasma membrane
.membrane organization
.regulation of protein transport
  + 15 more...
.myosin V binding
.GDP binding
.Rab GTPase binding
  + 2 more...
.primary cilium
.extracellular exosome
.recycling endosome membrane
  + 19 more...
6 EBI-748974,EBI-726075 RAB10  
  .establishment of protein localization to endoplasmic reticulum membrane
.establishment of protein localization to membrane
.protein localization to plasma membrane
  + 18 more...
.myosin V binding
.GDP binding
.GTP binding
.GTPase activity
.primary cilium
.endoplasmic reticulum tubular network
.extracellular exosome
  + 11 more...
7 EBI-748974,EBI-711788 MPP1  
  .regulation of neutrophil chemotaxis
.nucleotide phosphorylation
.signal transduction
.guanylate kinase activity .stereocilium
.cortical cytoskeleton
.membrane
  + 2 more...
8 EBI-748974,EBI-310758 DST  
  .cell motility
.intermediate filament cytoskeleton organization
.hemidesmosome assembly
  + 8 more...
.microtubule plus-end binding
.protein homodimerization activity
.protein C-terminus binding
  + 2 more...
.extracellular exosome
.intermediate filament cytoskeleton
.microtubule plus-end
  + 19 more...
9 EBI-748974,EBI-1056102 AKAP6  
  .positive regulation of delayed rectifier potassium channel activity
.positive regulation of potassium ion transmembrane transport
.cellular response to cytokine stimulus
  + 16 more...
.protein kinase A binding
.ion channel binding
.protein anchor
  + 3 more...
.perinuclear region of cytoplasm
.calcium channel complex
.nuclear membrane
  + 7 more...
10 EBI-748974,EBI-307104 SQSTM1  
  .activation of mitophagy in response to mitochondrial depolarization
.apoptotic signaling pathway
.protein heterooligomerization
  + 20 more...
.ubiquitin binding
.identical protein binding
.SH2 domain binding
  + 5 more...
.extracellular exosome
.cytoplasmic vesicle
.PML body
  + 11 more...
11 EBI-748974,EBI-1043216 SLMAP  
  .muscle contraction .N/A .sarcolemma
.integral component of plasma membrane
.microtubule organizing center
.smooth endoplasmic reticulum
12 EBI-748974,EBI-357849 TNIP1  
  .modulation by symbiont of host I-kappaB kinase/NF-kappaB cascade
.negative regulation of ERK1 and ERK2 cascade
.positive regulation of inflammatory response
  + 9 more...
.mitogen-activated protein kinase binding .cytoplasm
.nucleus
.intracellular
13 EBI-748974,EBI-724310 DAZAP2  
  .N/A .WW domain binding .cytoplasm
.nucleus
14 EBI-748974,EBI-7233259 ZNF329  
  .regulation of transcription, DNA-templated
.transcription, DNA-templated
.metal ion binding
.DNA binding
.nucleus
15 EBI-9091423,EBI-524753 ZDHHC17  
  .positive regulation of I-kappaB kinase/NF-kappaB signaling
.lipoprotein transport
.protein palmitoylation
  + 2 more...
.identical protein binding
.protein-cysteine S-palmitoyltransferase activity
.palmitoyltransferase activity
  + 3 more...
.intracellular membrane-bounded organelle
.Golgi-associated vesicle membrane
.integral component of membrane
  + 3 more...
16 EBI-748974,EBI-308277 HACE1  
  .protein K48-linked ubiquitination
.membrane fusion
.protein ubiquitination involved in ubiquitin-dependent protein catabolic process
  + 7 more...
.Rac GTPase binding
.Rab GTPase binding
.ligase activity
.ubiquitin-protein transferase activity
.Golgi cisterna membrane
.endoplasmic reticulum
.nucleus
.Golgi membrane
17 EBI-748974,EBI-1048247 TBC1D15  
  .positive regulation of GTPase activity
.regulation of GTPase activity
.GTPase activator activity .extracellular exosome
.mitochondrion
.cytoplasm
18 EBI-748974,EBI-8643207 ZNF398  
  .positive regulation of transcription, DNA-templated
.regulation of transcription, DNA-templated
.transcription, DNA-templated
.metal ion binding
.DNA binding
.nucleus
19 EBI-748974,EBI-681210 TTN  
  .cardiac muscle contraction
.cardiac muscle tissue morphogenesis
.cardiac myofibril assembly
  + 18 more...
.structural molecule activity conferring elasticity
.muscle alpha-actinin binding
.actin filament binding
  + 13 more...
.extracellular exosome
.I band
.M band
  + 5 more...
20 EBI-748974,EBI-745276 ZNF670  
  .regulation of transcription, DNA-templated
.transcription, DNA-templated
.metal ion binding
.DNA binding
.nucleus
21 EBI-748974,EBI-714625 TBC1D17  
  .retrograde transport, endosome to Golgi
.protein transport
.autophagy
.GTPase activator activity .cytoplasmic vesicle
.cytosol
.autophagic vacuole
22 EBI-748974,EBI-356402 TBK1  
  .defense response to virus
.defense response to Gram-positive bacterium
.positive regulation of transcription from RNA polymerase II promoter
  + 20 more...
.phosphoprotein binding
.ATP binding
.protein serine/threonine kinase activity
  + 2 more...
.endosome membrane
.cytosol
.cytoplasm
23 EBI-748974,EBI-396137 CDC23  
  .protein K11-linked ubiquitination
.regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
.positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition
  + 11 more...
.ubiquitin-protein transferase activity .cytosol
.anaphase-promoting complex
.nucleoplasm
.intracellular
24 EBI-748974,EBI-949294 SNX6  
  .negative regulation of transcription, DNA-templated
.retrograde transport, endosome to Golgi
.negative regulation of transforming growth factor beta receptor signaling pathway
  + 4 more...
.protein homodimerization activity
.phosphatidylinositol binding
.dynactin binding
.tubular endosome
.early endosome membrane
.retromer complex
  + 5 more...
25 EBI-748974,EBI-712969 CCDC53  
  .protein transport .N/A .WASH complex
.intracellular membrane-bounded organelle
.actin cytoskeleton
.early endosome
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue155
adrenal gland91
ascites25
bladder33
blood49
bone195
bone marrow20
brain98
cervix61
connective tissue100
ear62
embryonic tissue42
esophagus99
eye81
heart111
intestine68
kidney71
larynx85
liver102
lung107
lymph node11
mammary gland79
mouth30
muscle272
nerve128
ovary49
pancreas4
parathyroid48
pituitary gland121
placenta63
prostate63
skin85
spleen93
stomach20
testis91
thymus100
thyroid21
tonsil58
trachea57
umbilical cord217
uterus94
vascular135
Health State
TissuesTPM*
normal96
adrenal tumor79
bladder carcinoma113
breast (mammary gland) tumor64
cervical tumor86
chondrosarcoma156
colorectal tumor71
esophageal tumor115
gastrointestinal tumor25
germ cell tumor49
glioma27
head and neck tumor37
kidney tumor58
leukemia21
liver tumor135
lung tumor77
lymphoma55
non-neoplasia72
ovarian tumor52
primitive neuroectodermal tumor of the CNS47
prostate cancer38
skin tumor63
soft tissue/muscle tissue tumor23
uterine tumor88
Developmental Stage
TissuesTPM*
adult84
embryoid body85
neonate160
fetus87
infant42
juvenile53
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue77.8
adrenal gland82.9
appendix32.7
bone marrow25.9
cerebral cortex59.9
colon51
duodenum49.5
esophagus55.3
gallbladder40.8
heart muscle81.1
kidney70.6
liver48.1
lung39.6
lymph node38.8
ovary85.4
pancreas18.1
placenta44.6
prostate33
salivary gland34.8
skin53.5
small intestine58.2
spleen49.5
stomach54.1
testis77.5
thyroid gland20.8
urinary bladder47
Tissues
TissuesExpression level
adrenal glandMedium
appendixMedium
bone marrowHigh
breastMedium
bronchusMedium
cerebellumLow
cerebral cortexMedium
cervix, uterineMedium
colonHigh
duodenumMedium
endometrium 1Medium
endometrium 2Medium
epididymisMedium
esophagusMedium
fallopian tubeMedium
gallbladderMedium
heart muscleLow
hippocampusMedium
kidneyMedium
lateral ventricleMedium
liverLow
lungLow
lymph nodeMedium
nasopharynxHigh
oral mucosaMedium
ovaryLow
pancreasMedium
parathyroid glandMedium
placentaHigh
prostateLow
rectumMedium
salivary glandMedium
seminal vesicleMedium
skeletal muscleLow
skin 1Medium
skin 2Medium
small intestineMedium
smooth muscleLow
soft tissue 1Medium
soft tissue 2Low
spleenMedium
stomach 1Medium
stomach 2Medium
testisMedium
thyroid glandLow
tonsilHigh
urinary bladderMedium
vaginaMedium
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(#137760, phenotype) Glaucoma, primary open angle; POAGOMIM
2(*602432, gene) Optineurin; OPTNOMIM
3(#606657, phenotype) Glaucoma, normal tension, susceptibility toOMIM
4(#613435, phenotype) Amyotrophic lateral sclerosis 12; ALS12OMIM


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