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> Protein (NX_Q96DC9)
Protein (NX_Q96DC9)
Protein
Gene SymbolOTUB2 to neXtProt (NX_Q96DC9)
DescriptionUbiquitin thioesterase OTUB2
Chromosome14
Location14q32.12 (94492675 ~ 94515276) to Ensembl
Sequene Features : Isoforms 2, Variants 22, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.protein K48-linked deubiquitination
.protein K63-linked deubiquitination
.protein K11-linked deubiquitination
.protein deubiquitination
.ubiquitin-specific protease activity .nucleus
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
2 22 1
2014-09-19protein level
2 18 1
2014-05-27protein level
2 17 1
2014-02-25protein level
2 17 1
2013-12-09protein level
2 13 1
2013-11-01protein level
2 13 0
2013-09-12protein level
2 13 0
2013-08-17protein level
2 13 0
2013-07-15protein level
2 8 0
2013-06-11protein level
2 8 0
2013-02-12protein level
2 4 0
2012-12-20protein level
2 4 0
2012-10-30protein level
2 6 0
2012-10-07protein level
2 6 0
2012-08-24protein level
2 6 0
2012-07-28protein level
2 6 0
2012-06-08protein level
2 9 0
2012-05-07protein level
2 9 0
2012-04-10protein level
2 9 0
2012-01-13protein level
2 5 0
2011-12-20protein level
2 5 0
2011-11-11protein level
2 5 0
2011-08-23protein level
2 5 0
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q96DC9-1
8 4 0 27195.6245
NX_Q96DC9-2
0 4 0 8631.4847
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-746259,EBI-2340316 MID1  
  .interferon-gamma-mediated signaling pathway
.protein localization to microtubule
.positive regulation of stress-activated MAPK cascade
  + 4 more...
.phosphoprotein binding
.protein heterodimerization activity
.protein homodimerization activity
  + 5 more...
.microtubule associated complex
.microtubule
.cytosol
.spindle
2 EBI-746259,EBI-307352 REL  
  .negative regulation of neuron death
.positive regulation of transcription from RNA polymerase II promoter
.innate immune response
  + 10 more...
.sequence-specific DNA binding transcription factor activity
.chromatin binding
.RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
.RNA polymerase II distal enhancer sequence-specific DNA binding
.I-kappaB/NF-kappaB complex
.cytosol
.transcription factor complex
  + 2 more...
3 EBI-746259,EBI-10175039 TP53BP2  
  .positive regulation of execution phase of apoptosis
.intrinsic apoptotic signaling pathway by p53 class mediator
.negative regulation of cell cycle
  + 7 more...
.NF-kappaB binding
.identical protein binding
.SH3/SH2 adaptor activity
.p53 binding
.perinuclear region of cytoplasm
.cytoplasm
.nucleus
4 EBI-746259,EBI-358410 CPSF6  
  .protein tetramerization
.mRNA processing
.mRNA polyadenylation
.poly(A) RNA binding
.mRNA binding
.nucleotide binding
.paraspeckles
.ribonucleoprotein complex
.membrane
  + 3 more...
5 EBI-746259,EBI-747107 SIAH1  
  .positive regulation of intrinsic apoptotic signaling pathway
.neuron apoptotic process
.proteasome-mediated ubiquitin-dependent protein catabolic process
  + 11 more...
.ubiquitin protein ligase activity
.identical protein binding
.ligase activity
  + 3 more...
.beta-catenin destruction complex
.plasma membrane
.cytosol
  + 3 more...
6 EBI-746259,EBI-7957930 FAM168A  
  .N/A .N/A .N/A
7 EBI-746259,EBI-2875665 ARRDC3  
  .negative regulation of locomotion involved in locomotory behavior
.positive regulation of adrenergic receptor signaling pathway
.fat pad development
  + 5 more...
.beta-3 adrenergic receptor binding .plasma membrane
.endosome
8 EBI-746259,EBI-741037 LZTS2  
  .negative regulation of protein localization to nucleus
.negative regulation of canonical Wnt signaling pathway
.spindle midzone assembly
  + 7 more...
.N/A .midbody
.microtubule
.centrosome
.cytoplasm
9 EBI-746259,EBI-2130429 TRIM54  
  .cell differentiation
.multicellular organismal development
.signal transduction
  + 2 more...
.zinc ion binding
.signal transducer activity
.Z disc
.microtubule associated complex
.microtubule
10 EBI-746259,EBI-10172526 MID2  
  .negative regulation of viral release from host cell
.positive regulation of NF-kappaB transcription factor activity
.positive regulation of sequence-specific DNA binding transcription factor activity
  + 6 more...
.phosphoprotein binding
.protein heterodimerization activity
.protein homodimerization activity
  + 3 more...
.extracellular exosome
.microtubule
.cytoplasm
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
blood8
brain4
embryonic tissue4
eye38
heart22
intestine12
kidney9
liver4
lung5
mouth15
muscle9
pancreas14
placenta42
prostate5
stomach10
testis57
uterus17
Health State
TissuesTPM*
normal13
colorectal tumor8
gastrointestinal tumor25
germ cell tumor45
head and neck tumor7
kidney tumor29
leukemia21
liver tumor10
lung tumor9
pancreatic tumor28
prostate cancer9
retinoblastoma64
soft tissue/muscle tissue tumor31
Developmental Stage
TissuesTPM*
adult8
embryoid body14
fetus30
juvenile17
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
esophagus2.5
placenta2.1
skin3.8
testis4.9
urinary bladder1.2
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*608338, gene) Otu domain-containing ubiquitin aldehyde-binding protein 2; OTUB2OMIM


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