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> Protein (NX_Q96DZ9)
Protein (NX_Q96DZ9)
Protein
Gene SymbolCMTM5 to neXtProt (NX_Q96DZ9)
DescriptionCKLF-like MARVEL transmembrane domain-containing protein 5
Chromosome14
Location14q11.2 (23846017 ~ 23848981) to Ensembl
Sequene Features : Isoforms 6, Variants 40, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.negative regulation of myoblast differentiation
.chemotaxis
.N/A .integral component of membrane
.extracellular space
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
6 40 0
2014-09-19protein level
6 29 0
2014-05-27protein level
6 29 0
2014-02-25protein level
6 29 0
2013-12-09protein level
6 21 0
2013-11-01protein level
6 21 0
2013-09-12protein level
6 21 0
2013-08-17protein level
6 21 0
2013-07-15protein level
5 12 0
2013-06-11protein level
5 12 0
2013-02-12protein level
5 9 0
2012-12-20protein level
5 8 0
2012-10-30protein level
5 9 0
2012-10-07protein level
5 9 0
2012-08-24transcript level
5 8 0
2012-07-28transcript level
5 8 0
2012-06-08transcript level
5 0 0
2012-05-07transcript level
5 0 0
2012-04-10transcript level
5 0 0
2012-01-13transcript level
5 0 0
2011-12-20transcript level
5 1 0
2011-11-11transcript level
5 1 0
2011-08-23transcript level
5 1 0
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q96DZ9-1
2 5 0 24636.6162
NX_Q96DZ9-2
0 6 0 17433.0231
NX_Q96DZ9-3
1 5 0 13181.7497
NX_Q96DZ9-4
1 2 0 8250.2228
NX_Q96DZ9-5
1 4 0 11474.9556
NX_Q96DZ9-6
1 3 0 14208.2903
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-2548702,EBI-727004 SDCBP  
  .positive regulation of extracellular exosome assembly
.positive regulation of exosomal secretion
.ephrin receptor signaling pathway
  + 9 more...
.protein N-terminus binding
.protein heterodimerization activity
.syndecan binding
  + 4 more...
.blood microparticle
.extracellular exosome
.melanosome
  + 12 more...
2 EBI-2548702,EBI-861737 TIMM44  
  .cellular protein metabolic process
.protein import into mitochondrial matrix
.protein targeting to mitochondrion
.chaperone binding
.P-P-bond-hydrolysis-driven protein transmembrane transporter activity
.ATP binding
.mitochondrial matrix
.mitochondrial inner membrane
.mitochondrion
3 EBI-2548702,EBI-725795 PLIN3  
  .vesicle-mediated transport .N/A .intracellular membrane-bounded organelle
.membrane
.endosome membrane
  + 4 more...
4 EBI-2548702,EBI-2513774 FARS2  
  .gene expression
.tRNA processing
.phenylalanyl-tRNA aminoacylation
.tRNA aminoacylation for protein translation
.ATP binding
.phenylalanine-tRNA ligase activity
.magnesium ion binding
.tRNA binding
.mitochondrial matrix
.mitochondrion
5 EBI-2548702,EBI-701692 APOA1  
  .positive regulation of substrate adhesion-dependent cell spreading
.cholesterol import
.triglyceride homeostasis
  + 61 more...
.high-density lipoprotein particle receptor binding
.phosphatidylcholine-sterol O-acyltransferase activator activity
.lipase inhibitor activity
  + 12 more...
.blood microparticle
.endocytic vesicle lumen
.extracellular exosome
  + 17 more...
6 EBI-2548702,EBI-10194262 CYP1A1  
  .positive regulation of G1/S transition of mitotic cell cycle
.omega-hydroxylase P450 pathway
.cellular response to organic cyclic compound
  + 37 more...
.vitamin D 24-hydroxylase activity
.aromatase activity
.demethylase activity
  + 7 more...
.endoplasmic reticulum membrane
.mitochondrion
7 EBI-2548702,EBI-739696 LMO2  
  .cellular response to thyroid hormone stimulus
.positive regulation of transcription from RNA polymerase II promoter
.negative regulation of erythrocyte differentiation
  + 3 more...
.E-box binding
.cofactor binding
.bHLH transcription factor binding
  + 7 more...
.transcription factor complex
.nucleus
8 EBI-2548702,EBI-5544229 PPIF  
  .negative regulation of intrinsic apoptotic signaling pathway
.negative regulation of oxidative phosphorylation uncoupler activity
.regulation of mitochondrial membrane permeability involved in programmed necrotic cell death
  + 16 more...
.cyclosporin A binding
.peptidyl-prolyl cis-trans isomerase activity
.membrane
.mitochondrial matrix
.mitochondrial inner membrane
9 EBI-2548702,EBI-352908 SHMT2  
  .protein homotetramerization
.tetrahydrofolate interconversion
.glycine biosynthetic process from serine
  + 3 more...
.pyridoxal phosphate binding
.amino acid binding
.L-allo-threonine aldolase activity
  + 2 more...
.extracellular exosome
.mitochondrial nucleoid
.microtubule cytoskeleton
  + 4 more...
10 EBI-2548702,EBI-742898 PTPN9  
  .peptidyl-tyrosine dephosphorylation
.protein dephosphorylation
.non-membrane spanning protein tyrosine phosphatase activity
.protein tyrosine phosphatase activity
.cytoplasm
11 EBI-2548702,EBI-359097 TUFM  
  .mitochondrial translational elongation
.mitochondrial translation
.organelle organization
.translational elongation
.poly(A) RNA binding
.GTP binding
.GTPase activity
.translation elongation factor activity
.extracellular exosome
.mitochondrial nucleoid
.membrane
.mitochondrion
12 EBI-2548702,EBI-10210710 TTPA  
  .negative regulation of establishment of blood-brain barrier
.negative regulation of cell death
.intracellular pH reduction
  + 9 more...
.phosphatidylinositol-3,4-bisphosphate binding
.vitamin E binding
.phosphatidylinositol-4,5-bisphosphate binding
.transporter activity
.cytosol
.late endosome
13 EBI-2548702,EBI-1210304 ALDH18A1  
  .L-proline biosynthetic process
.small molecule metabolic process
.cellular nitrogen compound metabolic process
  + 5 more...
.NADP binding
.poly(A) RNA binding
.ATP binding
  + 2 more...
.mitochondrial inner membrane
.mitochondrion
.cytoplasm
14 EBI-2548702,EBI-9304251 GAD2  
  .response to drug
.neurotransmitter biosynthetic process
.neurotransmitter secretion
  + 2 more...
.pyridoxal phosphate binding
.glutamate binding
.glutamate decarboxylase activity
.clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane
.perinuclear region of cytoplasm
.presynaptic membrane
  + 7 more...
15 EBI-2548702,EBI-357956 GTF3C1  
  .tRNA transcription from RNA polymerase III promoter
.5S class rRNA transcription from RNA polymerase III type 1 promoter
.gene expression
  + 4 more...
.DNA binding .ribonucleoprotein complex
.membrane
.nucleolus
  + 3 more...
16 EBI-2548702,EBI-2822329 SNX1  
  .lamellipodium morphogenesis
.positive regulation of protein catabolic process
.retrograde transport, endosome to Golgi
  + 4 more...
.leptin receptor binding
.transferrin receptor binding
.identical protein binding
  + 3 more...
.protein complex
.intracellular membrane-bounded organelle
.early endosome membrane
  + 8 more...
17 EBI-2548702,EBI-10244969 VARS2  
  .gene expression
.valyl-tRNA aminoacylation
.tRNA aminoacylation for protein translation
.ATP binding
.valine-tRNA ligase activity
.aminoacyl-tRNA editing activity
.mitochondrion
18 EBI-2548702,EBI-521451 ECM29  
  .ER-associated ubiquitin-dependent protein catabolic process .N/A .endocytic vesicle
.ER to Golgi transport vesicle
.cytoplasmic membrane-bounded vesicle
  + 9 more...
19 EBI-2548702,EBI-8635958 SPATA8  
  .N/A .N/A .N/A
20 EBI-2548702,EBI-10256202 RSRC2  
  .N/A .poly(A) RNA binding .N/A
21 EBI-2548702,EBI-10256990 ARMC9  
  .N/A .N/A .extracellular exosome
22 EBI-2548702,EBI-10259474 AACS  
  .cellular response to cholesterol
.cellular response to testosterone stimulus
.cellular response to glucose stimulus
  + 11 more...
.butyrate-CoA ligase activity
.acetoacetate-CoA ligase activity
.ATP binding
.cytosol
23 EBI-2548702,EBI-2686288 FAM114A1  
  .N/A .N/A .cytoplasm
24 EBI-2548702,EBI-3232108 RBFA  
  .rRNA processing .N/A .mitochondrion
25 EBI-2548702,EBI-7131783 SYNE4  
  .establishment of epithelial cell apical/basal polarity .N/A .LINC complex
.integral component of nuclear outer membrane
26 EBI-2548702,EBI-2561661 PPP2R3C  
  .regulation of mitochondrial depolarization
.spleen development
.positive regulation of B cell differentiation
  + 6 more...
.metal ion binding .spindle
.centrosome
.cytoplasm
.nucleus
27 EBI-2548702,EBI-2876502 ACSF2  
  .fatty acid metabolic process .ligase activity
.ATP binding
.mitochondrion
28 EBI-2548702,EBI-7825321 MTERF3  
  .negative regulation of transcription, DNA-templated
.transcription, DNA-templated
.transcription regulatory region DNA binding
.double-stranded DNA binding
.mitochondrion
29 EBI-2548702,EBI-2340249 RNF185  
  .protein ubiquitination
.autophagy
.ligase activity
.zinc ion binding
.integral component of membrane
.endoplasmic reticulum membrane
.mitochondrial outer membrane
30 EBI-2548702,EBI-932162 TPD52L3  
  .N/A .N/A .N/A
31 EBI-2548702,EBI-2806908 RMDN2  
  .N/A .N/A .integral component of membrane
.microtubule
.mitochondrion
  + 2 more...
32 EBI-2548702,EBI-10292326 MCEE  
  .L-methylmalonyl-CoA metabolic process
.small molecule metabolic process
.cellular lipid metabolic process
  + 2 more...
.metal ion binding
.methylmalonyl-CoA epimerase activity
.mitochondrial matrix
33 EBI-2548702,EBI-743184 GAD1  
  .response to drug
.neurotransmitter biosynthetic process
.protein-pyridoxal-5-phosphate linkage
  + 5 more...
.pyridoxal phosphate binding
.glutamate binding
.glutamate decarboxylase activity
.clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane
.vesicle membrane
.plasma membrane
.intracellular
34 EBI-2548702,EBI-10295431 SSX3  
  .regulation of transcription, DNA-templated
.transcription, DNA-templated
.nucleic acid binding .nucleus
35 EBI-2548702,EBI-2510241 DDA1  
  .N/A .N/A .N/A
36 EBI-2548702,EBI-2859814 GLTP  
  .glycolipid transport
.small molecule metabolic process
.glycosphingolipid metabolic process
.sphingolipid metabolic process
.glycolipid binding
.glycolipid transporter activity
.lipid binding
.extracellular exosome
.membrane
.cytosol
37 EBI-2548702,EBI-742688 SPG21  
  .antigen receptor-mediated signaling pathway .CD4 receptor binding .trans-Golgi network transport vesicle
.endosome membrane
.cytosol
  + 3 more...
38 EBI-2548702,EBI-749241 PITPNC1  
  .phospholipid transport
.signal transduction
.phosphatidylinositol transporter activity
.lipid binding
.cytoplasm
.nucleoplasm
39 EBI-2548702,EBI-10323810 NDRG4  
  .positive regulation of ERK1 and ERK2 cascade
.cardiac muscle cell proliferation
.negative regulation of smooth muscle cell proliferation
  + 9 more...
.N/A .basolateral plasma membrane
.cytosol
.endoplasmic reticulum membrane
  + 2 more...
40 EBI-2548702,EBI-2623095 SH3GLB1  
  .positive regulation of autophagic vacuole assembly
.positive regulation of protein targeting to mitochondrion
.protein localization to vacuolar membrane
  + 11 more...
.protein homodimerization activity
.identical protein binding
.lipid binding
.extracellular exosome
.midbody
.mitochondrial outer membrane
  + 3 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
brain33
eye28
kidney9
nerve64
prostate5
Health State
TissuesTPM*
normal11
glioma74
kidney tumor14
non-neoplasia10
Developmental Stage
TissuesTPM*
adult6
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue1
adrenal gland1.1
bone marrow4.5
cerebral cortex48.8
colon1.3
esophagus1.2
gallbladder3
heart muscle6
lung1.2
prostate1.8
salivary gland1.5
small intestine1.5
spleen1.7
Tissues
TissuesExpression level
bone marrowMedium
cerebellumMedium
cerebral cortexMedium
colonMedium
duodenumLow
esophagusLow
gallbladderLow
hippocampusMedium
kidneyLow
lateral ventricleMedium
skin 1Low
skin 2Low
soft tissue 2High
stomach 2Low
thyroid glandLow
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*607888, gene) Cklf-like marvel transmembrane domain-containing 5; CMTM5OMIM


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