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> Protein (NX_Q96EB6)
Protein (NX_Q96EB6)
Protein
Gene SymbolSIRT1 to neXtProt (NX_Q96EB6)
DescriptionNAD-dependent protein deacetylase sirtuin-1
Chromosome10
Location10q21.3 (69644427 ~ 69678147) to Ensembl
Sequene Features : Isoforms 2, Variants 69, PTMs 23 to neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.positive regulation of cellular senescence
.negative regulation of cellular senescence
.negative regulation of peptidyl-lysine acetylation
  + 102 more...
.keratin filament binding
.NAD+ binding
.mitogen-activated protein kinase binding
  + 17 more...
.rDNA heterochromatin
.PML body
.mitochondrion
  + 10 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
2 69 23
2014-09-19protein level
2 54 23
2014-05-27protein level
2 54 23
2014-02-25protein level
2 53 23
2013-12-09protein level
2 36 23
2013-11-01protein level
2 34 19
2013-09-12protein level
2 34 19
2013-08-17protein level
2 34 19
2013-07-15protein level
2 26 19
2013-06-11protein level
2 26 19
2013-02-12protein level
2 17 36
2012-12-20protein level
2 15 36
2012-10-30protein level
2 20 36
2012-10-07protein level
2 20 20
2012-08-24protein level
2 20 20
2012-07-28protein level
2 19 20
2012-06-08protein level
2 36 20
2012-05-07protein level
2 31 20
2012-04-10protein level
2 31 20
2012-01-13protein level
2 31 20
2011-12-20protein level
1 17 11
2011-11-11protein level
1 17 11
2011-08-23protein level
1 17 11
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q96EB6-1
11 22 0 81629.7317
NX_Q96EB6-2
1 22 0 61027.5017
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-1802965,EBI-389606 TP73  
  .positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
.negative regulation of cardiac muscle cell proliferation
.protein tetramerization
  + 31 more...
.metal ion binding
.transcription regulatory region DNA binding
.identical protein binding
  + 10 more...
.intracellular membrane-bounded organelle
.cell junction
.cytosol
  + 5 more...
2 EBI-1802965,EBI-2008793 RRP8  
  .intrinsic apoptotic signaling pathway by p53 class mediator
.positive regulation of cell cycle arrest
.regulation of transcription by glucose
  + 8 more...
.poly(A) RNA binding
.methylated histone binding
.S-adenosylmethionine-dependent methyltransferase activity
.rDNA heterochromatin
.plasma membrane
.cytoplasm
  + 4 more...
3 EBI-1802965,EBI-1644164 FOXO3  
  .regulation of reactive oxygen species metabolic process
.regulation of neural precursor cell proliferation
.extrinsic apoptotic signaling pathway in absence of ligand
  + 24 more...
.sequence-specific DNA binding
.chromatin DNA binding
.protein kinase binding
  + 5 more...
.membrane
.cytosol
.cytoplasm
  + 2 more...
4 EBI-1802965,EBI-494844 NBN  
  .intrinsic apoptotic signaling pathway
.meiotic cell cycle
.neuromuscular process controlling balance
  + 16 more...
.protein N-terminus binding
.transcription factor binding
.damaged DNA binding
.nuclear inclusion body
.site of double-strand break
.Mre11 complex
  + 6 more...
5 EBI-1802965,EBI-447544 MYC  
  .positive regulation of response to DNA damage stimulus
.positive regulation of DNA biosynthetic process
.positive regulation of metanephric cap mesenchymal cell proliferation
  + 36 more...
.E-box binding
.repressing transcription factor binding
.protein complex binding
  + 5 more...
.protein complex
.cytosol
.nucleolus
  + 2 more...
6 EBI-1802965,EBI-878369 MYCN  
  .negative regulation of reactive oxygen species metabolic process
.branching morphogenesis of an epithelial tube
.negative regulation of astrocyte differentiation
  + 8 more...
.sequence-specific DNA binding transcription factor activity
.DNA binding
.nucleus
.chromatin
7 EBI-1802965,EBI-366083 TP53  
  .positive regulation of intrinsic apoptotic signaling pathway
.positive regulation of reactive oxygen species metabolic process
.negative regulation of reactive oxygen species metabolic process
  + 99 more...
.protein phosphatase 2A binding
.chaperone binding
.protein N-terminus binding
  + 27 more...
.protein complex
.PML body
.nuclear matrix
  + 11 more...
8 EBI-1802965,EBI-413374 RARA  
  .cellular response to estrogen stimulus
.cellular response to retinoic acid
.cellular response to lipopolysaccharide
  + 54 more...
.alpha-actinin binding
.protein kinase A binding
.mRNA 5'-UTR binding
  + 19 more...
.perinuclear region of cytoplasm
.neuronal cell body
.dendrite
  + 6 more...
9 EBI-1802965,EBI-353208 XRCC6  
  .establishment of integrated proviral latency
.cellular response to X-ray
.cellular hyperosmotic salinity response
  + 16 more...
.5'-deoxyribose-5-phosphate lyase activity
.poly(A) RNA binding
.transcription regulatory region DNA binding
  + 7 more...
.nonhomologous end joining complex
.Ku70:Ku80 complex
.membrane
  + 6 more...
10 EBI-1802965,EBI-295222 XPA  
  .multicellular organism growth
.nucleotide-excision repair, DNA incision
.response to toxic substance
  + 6 more...
.metal ion binding
.protein homodimerization activity
.protein domain specific binding
.damaged DNA binding
.intercellular bridge
.Golgi apparatus
.cytoplasm
  + 2 more...
11 EBI-1802965,EBI-719459 DNMT1  
  .cellular response to amino acid stimulus
.negative regulation of histone H3-K9 methylation
.positive regulation of histone H3-K4 methylation
  + 12 more...
.DNA-methyltransferase activity
.methyl-CpG binding
.zinc ion binding
  + 4 more...
.pericentric heterochromatin
.replication fork
.nucleoplasm
.nucleus
12 EBI-1802965,EBI-1048805 APEX1  
  .negative regulation of nucleic acid-templated transcription
.positive regulation of G1/S transition of mitotic cell cycle
.DNA demethylation
  + 25 more...
.metal ion binding
.poly(A) RNA binding
.chromatin DNA binding
  + 15 more...
.perinuclear region of cytoplasm
.nuclear speck
.ribosome
  + 8 more...
13 EBI-1802965,EBI-79464 PIK3R1  
  .positive regulation of endoplasmic reticulum unfolded protein response
.positive regulation of establishment of protein localization to plasma membrane
.growth hormone receptor signaling pathway
  + 41 more...
.1-phosphatidylinositol-3-kinase regulator activity
.insulin receptor substrate binding
.insulin binding
  + 9 more...
.membrane
.phosphatidylinositol 3-kinase complex, class IA
.phosphatidylinositol 3-kinase complex
  + 5 more...
14 EBI-1802965,EBI-296087 AKT1  
  .negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
.response to insulin-like growth factor stimulus
.negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
  + 108 more...
.14-3-3 protein binding
.phosphatidylinositol-3,4-bisphosphate binding
.identical protein binding
  + 8 more...
.ciliary basal body
.microtubule cytoskeleton
.cell-cell junction
  + 7 more...
15 EBI-1802965,EBI-1538819 CIITA  
  .interferon-gamma-mediated signaling pathway
.response to antibiotic
.positive regulation of transcription from RNA polymerase II promoter
  + 10 more...
.transcription regulatory region DNA binding
.activating transcription factor binding
.protein complex binding
  + 6 more...
.PML body
.nucleoplasm
16 EBI-1802965,EBI-948338 SREBF1  
  .regulation of protein targeting to mitochondrion
.regulation of mitochondrion degradation
.cellular response to fatty acid
  + 26 more...
.sequence-specific DNA binding
.sterol response element binding
.sequence-specific DNA binding transcription factor activity
  + 2 more...
.protein complex
.integral component of membrane
.ER to Golgi transport vesicle membrane
  + 8 more...
17 EBI-1802965,EBI-359260 MTOR  
  .negative regulation of mitochondrion degradation
.regulation of cellular response to heat
.cellular response to hypoxia
  + 54 more...
.phosphoprotein binding
.protein dimerization activity
.ribosome binding
  + 8 more...
.neuronal cell body
.TORC2 complex
.TORC1 complex
  + 14 more...
18 EBI-1802965,EBI-396587 TSC2  
  .negative regulation of protein kinase B signaling
.regulation of cell cycle
.protein heterooligomerization
  + 39 more...
.protein homodimerization activity
.phosphatase binding
.GTPase activator activity
.perinuclear region of cytoplasm
.neuronal cell body
.TSC1-TSC2 complex
  + 9 more...
19 EBI-1802965,EBI-396176 HCFC1  
  .protein stabilization
.positive regulation of cell cycle
.histone H4-K16 acetylation
  + 12 more...
.identical protein binding
.transcription coactivator activity
.sequence-specific DNA binding transcription factor activity
  + 2 more...
.MLL1 complex
.MLL5-L complex
.Set1C/COMPASS complex
  + 7 more...
20 EBI-1802965,EBI-348169 CSNK2B  
  .endothelial tube morphogenesis
.regulation of DNA binding
.regulation of protein kinase activity
  + 11 more...
.metal ion binding
.identical protein binding
.protein domain specific binding
  + 4 more...
.extracellular exosome
.protein kinase CK2 complex
.cytosol
  + 2 more...
21 EBI-1802965,EBI-347804 CSNK2A1  
  .mitotic spindle checkpoint
.chaperone-mediated protein folding
.rhythmic process
  + 12 more...
.Hsp90 protein binding
.protein N-terminus binding
.ATP binding
.protein serine/threonine kinase activity
.NuRD complex
.Sin3 complex
.plasma membrane
  + 2 more...
22 EBI-1802965,EBI-4481939 FOXO4  
  .negative regulation of G0 to G1 transition
.negative regulation of smooth muscle cell differentiation
.stem cell differentiation
  + 16 more...
.sequence-specific DNA binding
.enzyme binding
.transcription factor binding
  + 3 more...
.cytosol
.cytoplasm
.nucleoplasm
.nucleus
23 EBI-1802965,EBI-448924 E2F1  
  .regulation of G1/S transition of mitotic cell cycle
.lens fiber cell apoptotic process
.positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
  + 27 more...
.sequence-specific DNA binding
.transcription factor binding
.sequence-specific DNA binding transcription factor activity
  + 2 more...
.Rb-E2F complex
.cytoplasm
.nucleoplasm
.nucleus
24 EBI-1802965,EBI-5378683 NHLH2  
  .positive regulation of sequence-specific DNA binding transcription factor activity
.positive regulation of transcription from RNA polymerase II promoter
.ovulation cycle
  + 4 more...
.RNA polymerase II activating transcription factor binding
.sequence-specific DNA binding RNA polymerase II transcription factor activity
.RNA polymerase II regulatory region sequence-specific DNA binding
.transcription factor complex
.nucleus
25 EBI-1802965,EBI-1384862 MECOM  
  .renal system development
.hematopoietic stem cell proliferation
.pericardium development
  + 19 more...
.metal ion binding
.protein homodimerization activity
.sequence-specific DNA binding transcription factor activity
.DNA binding
.intracellular membrane-bounded organelle
.nuclear speck
.aggresome
  + 5 more...
26 EBI-1802965,EBI-73886 RELA  
  .negative regulation of extrinsic apoptotic signaling pathway
.positive regulation of miRNA metabolic process
.negative regulation of NIK/NF-kappaB signaling
  + 64 more...
.repressing transcription factor binding
.NF-kappaB binding
.protein N-terminus binding
  + 20 more...
.NF-kappaB complex
.I-kappaB/NF-kappaB complex
.cytosol
  + 4 more...
27 EBI-1802965,EBI-711424 TLE1  
  .negative regulation of anoikis
.negative regulation of transcription, DNA-templated
.negative regulation of I-kappaB kinase/NF-kappaB signaling
  + 7 more...
.identical protein binding
.transcription factor binding
.chromatin binding
.RNA polymerase II transcription corepressor activity
.cytosol
.cytoplasm
.nucleolus
  + 3 more...
28 EBI-1802965,EBI-447295 EP300  
  .negative regulation of protein stabilization
.regulation of cellular response to heat
.regulation of tubulin deacetylation
  + 40 more...
.pre-mRNA intronic binding
.androgen receptor binding
.nuclear hormone receptor binding
  + 17 more...
.cytoplasm
.transcription factor complex
.nucleoplasm
  + 2 more...
29 EBI-1802965,EBI-1108782 FOXO1  
  .regulation of energy homeostasis
.regulation of reactive oxygen species metabolic process
.regulation of neural precursor cell proliferation
  + 38 more...
.protein phosphatase 2A binding
.sequence-specific DNA binding
.ubiquitin protein ligase binding
  + 4 more...
.cytosol
.mitochondrion
.cytoplasm
  + 2 more...
30 EBI-1802965,EBI-717681 ACACA  
  .malonyl-CoA biosynthetic process
.lipid homeostasis
.protein homotetramerization
  + 14 more...
.metal ion binding
.ATP binding
.biotin carboxylase activity
.acetyl-CoA carboxylase activity
.extracellular exosome
.actin cytoskeleton
.cytosol
  + 3 more...
31 EBI-1802965,EBI-632715 SNW1  
  .cellular response to retinoic acid
.positive regulation of vitamin D receptor signaling pathway
.regulation of vitamin D receptor signaling pathway
  + 19 more...
.SMAD binding
.poly(A) RNA binding
.retinoic acid receptor binding
  + 5 more...
.catalytic step 2 spliceosome
.nuclear matrix
.spliceosomal complex
  + 3 more...
32 EBI-1802965,EBI-368417 WRN  
  .nucleic acid phosphodiester bond hydrolysis
.cellular response to gamma radiation
.positive regulation of hydrolase activity
  + 23 more...
.G-quadruplex DNA binding
.ATP-dependent 3'-5' DNA helicase activity
.3'-5' DNA helicase activity
  + 15 more...
.centrosome
.nucleolus
.nucleoplasm
33 EBI-1802965,EBI-701903 FHL2  
  .heart trabecula formation
.ventricular cardiac muscle cell development
.atrial cardiac muscle cell development
  + 9 more...
.androgen receptor binding
.identical protein binding
.zinc ion binding
  + 2 more...
.M band
.Z disc
.actin cytoskeleton
  + 3 more...
34 EBI-1802965,EBI-2832522 HES1  
  .negative regulation of forebrain neuron differentiation
.negative regulation of pro-B cell differentiation
.negative regulation of stem cell differentiation
  + 64 more...
.N-box binding
.sequence-specific DNA binding
.histone deacetylase binding
  + 5 more...
.cytoplasm
.nucleoplasm
.nucleus
35 EBI-1802965,EBI-3910729 NR0B2  
  .negative regulation of sequence-specific DNA binding transcription factor activity
.positive regulation of insulin secretion
.organ regeneration
  + 7 more...
.protein homodimerization activity
.protein domain specific binding
.transcription corepressor activity
  + 3 more...
.protein complex
.cytoplasm
.nucleoplasm
.nucleus
36 EBI-1802965,EBI-4479407 RPS19BP1  
  .N/A .poly(A) RNA binding
.enzyme binding
.cytoplasm
.nucleolus
.nucleoplasm
37 EBI-1802965,EBI-1567928 RPTOR  
  .regulation of cellular response to heat
.positive regulation of protein serine/threonine kinase activity
.cellular response to amino acid stimulus
  + 12 more...
.14-3-3 protein binding
.protein complex binding
.protein kinase binding
  + 4 more...
.intracellular membrane-bounded organelle
.neuronal cell body
.TORC1 complex
  + 6 more...
38 EBI-1802965,EBI-355410 CCAR2  
  .positive regulation of DNA damage checkpoint
.negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage
.regulation of cellular response to heat
  + 14 more...
.poly(A) RNA binding
.enzyme binding
.enzyme inhibitor activity
.RNA polymerase II core binding
.DBIRD complex
.mitochondrial matrix
.cytoplasm
  + 3 more...
39 EBI-1802965,EBI-477430 KAT2B  
  .rhythmic process
.positive regulation of transcription from RNA polymerase II promoter
.negative regulation of cyclin-dependent protein serine/threonine kinase activity
  + 19 more...
.histone deacetylase binding
.protein complex binding
.protein kinase binding
  + 7 more...
.actomyosin
.I band
.A band
  + 5 more...
40 EBI-1802965,EBI-3917542 NMNAT1  
  .small molecule metabolic process
.NAD metabolic process
.NAD biosynthetic process
  + 2 more...
.ATP binding
.nicotinate-nucleotide adenylyltransferase activity
.nicotinamide-nucleotide adenylyltransferase activity
.nucleoplasm
.nucleus
41 EBI-1802965,EBI-632965 CREBZF  
  .regulation of sequence-specific DNA binding transcription factor activity
.negative regulation of transcription, DNA-templated
.negative regulation of gene expression, epigenetic
  + 2 more...
.sequence-specific DNA binding
.identical protein binding
.sequence-specific DNA binding transcription factor activity
.DNA binding
.nucleus
42 EBI-1802965,EBI-750630 HEY2  
  .regulation of vasculogenesis
.negative regulation of transcription from RNA polymerase II promoter involved in smooth muscle cell differentiation
.negative regulation of cardiac vascular smooth muscle cell differentiation
  + 47 more...
.sequence-specific DNA binding
.histone deacetylase binding
.microsatellite binding
  + 5 more...
.transcriptional repressor complex
.cytoplasm
.nucleoplasm
.nucleus
43 EBI-1802965,EBI-1049582 IRS2  
  .cellular response to glucose stimulus
.JAK-STAT cascade involved in growth hormone signaling pathway
.lipid homeostasis
  + 27 more...
.phosphatidylinositol 3-kinase binding
.insulin receptor binding
.signal transducer activity
.plasma membrane
.cytosol
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adrenal gland60
bone41
brain13
cervix20
ear186
embryonic tissue14
eye14
intestine17
kidney4
liver9
lung11
lymph22
lymph node77
mammary gland26
muscle9
pancreas28
parathyroid48
pituitary gland60
placenta21
prostate31
salivary gland49
skin14
spleen18
testis27
thymus25
tonsil58
trachea19
uterus25
vascular19
Health State
TissuesTPM*
normal21
breast (mammary gland) tumor21
cervical tumor28
colorectal tumor8
gastrointestinal tumor8
germ cell tumor18
leukemia31
liver tumor10
lung tumor9
lymphoma27
pancreatic tumor9
prostate cancer48
retinoblastoma21
skin tumor7
soft tissue/muscle tissue tumor15
uterine tumor11
Developmental Stage
TissuesTPM*
adult16
embryoid body14
blastocyst16
fetus23
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue14
adrenal gland33.2
appendix12.4
bone marrow12.8
cerebral cortex9.1
colon11.5
duodenum9
esophagus11.8
gallbladder16.1
heart muscle8.6
kidney11.7
liver9.3
lung12.1
lymph node17.8
ovary24.4
pancreas6.4
placenta12.5
prostate12.4
salivary gland7.5
skin8.2
small intestine9.6
spleen13.6
stomach10
testis26.7
thyroid gland15.4
urinary bladder16.7
Tissues
TissuesExpression level
adrenal glandHigh
appendixMedium
bone marrowHigh
breastMedium
bronchusHigh
cerebellumMedium
cerebral cortexHigh
cervix, uterineMedium
colonMedium
duodenumMedium
endometrium 1Medium
endometrium 2Medium
epididymisMedium
esophagusHigh
fallopian tubeMedium
gallbladderLow
heart muscleMedium
hippocampusHigh
kidneyMedium
lateral ventricleHigh
liverMedium
lungHigh
lymph nodeHigh
nasopharynxHigh
oral mucosaHigh
ovaryLow
pancreasMedium
parathyroid glandLow
placentaHigh
prostateMedium
rectumMedium
salivary glandLow
seminal vesicleMedium
skeletal muscleLow
skin 1Medium
skin 2Medium
small intestineMedium
smooth muscleMedium
soft tissue 2Low
spleenLow
stomach 1Medium
stomach 2Medium
testisHigh
thyroid glandLow
tonsilMedium
urinary bladderHigh
vaginaHigh
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*604479, gene) Sirtuin 1; SIRT1OMIM


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