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> Protein (NX_Q96EV8)
Protein (NX_Q96EV8)
Protein
Gene SymbolDTNBP1 to neXtProt (NX_Q96EV8)
DescriptionDysbindin
Chromosome6
Location6p22.3 (15523032 ~ 15663289) to Ensembl
Sequene Features : Isoforms 3, Variants 52, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.membrane organization
.regulation of dopamine receptor signaling pathway
.platelet dense granule organization
  + 11 more...
.N/A .postsynaptic membrane
.dendritic spine
.neuron projection
  + 14 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
3 52 3
2014-09-19protein level
3 39 3
2014-05-27protein level
3 39 3
2014-02-25protein level
3 39 6
2013-12-09protein level
3 28 6
2013-11-01protein level
3 27 6
2013-09-12protein level
3 27 6
2013-08-17protein level
3 27 6
2013-07-15protein level
3 22 6
2013-06-11protein level
3 22 6
2013-02-12protein level
2 13 8
2012-12-20protein level
2 13 8
2012-10-30protein level
2 14 8
2012-10-07protein level
2 14 5
2012-08-24protein level
2 12 5
2012-07-28protein level
2 12 5
2012-06-08protein level
2 14 5
2012-05-07protein level
2 14 5
2012-04-10protein level
2 14 5
2012-01-13protein level
2 13 5
2011-12-20protein level
2 13 5
2011-11-11protein level
2 13 5
2011-08-23protein level
2 13 5
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q96EV8-1
0 13 0 39468.0773
NX_Q96EV8-2
3 9 0 34808.3139
NX_Q96EV8-3
1 9 0 30367.3016
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-465804,EBI-10285373 ELOVL7  
  .small molecule metabolic process
.cellular lipid metabolic process
.very long-chain fatty acid biosynthetic process
  + 4 more...
.transferase activity .integral component of membrane
.endoplasmic reticulum membrane
.endoplasmic reticulum
2 EBI-465804,EBI-10172867 SSC5D  
  .negative regulation of interleukin-8 secretion
.defense response to Gram-positive bacterium
.defense response to Gram-negative bacterium
  + 4 more...
.extracellular matrix binding
.laminin binding
.scavenger receptor activity
.fibronectin binding
.extracellular matrix
.membrane
.cytoplasm
  + 2 more...
3 EBI-465804,EBI-727004 SDCBP  
  .positive regulation of extracellular exosome assembly
.positive regulation of exosomal secretion
.ephrin receptor signaling pathway
  + 9 more...
.protein N-terminus binding
.protein heterodimerization activity
.syndecan binding
  + 4 more...
.blood microparticle
.extracellular exosome
.melanosome
  + 12 more...
4 EBI-465804,EBI-740402 DTNB  
  .N/A .zinc ion binding .synapse
.cytoplasm
5 EBI-465804,EBI-296723 SNAPIN  
  .positive regulation of late endosome to lysosome transport
.autophagic vacuole maturation
.terminal button organization
  + 14 more...
.SNARE binding .perinuclear region of cytoplasm
.synapse
.BLOC-1 complex
  + 9 more...
6 EBI-465804,EBI-719493 TRIM27  
  .negative regulation of viral release from host cell
.negative regulation of interleukin-2 secretion
.negative regulation of calcium ion import
  + 17 more...
.metal ion binding
.ligase activity
.zinc ion binding
  + 4 more...
.nuclear membrane
.PML body
.membrane
  + 6 more...
7 EBI-465804,EBI-348630 BLOC1S1  
  .activation of mitophagy in response to mitochondrial depolarization
.membrane organization
.platelet dense granule organization
  + 7 more...
.N/A .extracellular exosome
.BLOC-1 complex
.cytosol
  + 4 more...
8 EBI-465804,EBI-10241443 CCDC153  
  .N/A .N/A .N/A
9 EBI-465804,EBI-465930 BLOC1S3  
  .membrane organization
.platelet dense granule organization
.anterograde synaptic vesicle transport
  + 12 more...
.N/A .BLOC-1 complex
.transport vesicle
.cytosol
10 EBI-465804,EBI-465872 BLOC1S2  
  .mitochondrial outer membrane permeabilization
.platelet dense granule organization
.anterograde synaptic vesicle transport
  + 8 more...
.gamma-tubulin binding
.protein C-terminus binding
.recycling endosome
.BLOC-1 complex
.centrosome
  + 3 more...
11 EBI-465804,EBI-10181968 P4HA3  
  .N/A .L-ascorbic acid binding
.oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
.iron ion binding
.procollagen-proline 4-dioxygenase activity
.endoplasmic reticulum lumen
12 EBI-465804,EBI-744203 IFT20  
  .regulation of autophagic vacuole assembly
.regulation of cilium assembly
.protein localization to cilium
  + 13 more...
.N/A .ciliary base
.ciliary tip
.primary cilium
  + 13 more...
13 EBI-465804,EBI-10247802 CCDC146  
  .N/A .N/A .centriole
14 EBI-465804,EBI-10175300 CCHCR1  
  .cell differentiation
.multicellular organismal development
.protein export from nucleus
.N/A .centriole
.cytoplasm
.nucleus
15 EBI-465804,EBI-465861 BLOC1S5  
  .positive regulation of pigment cell differentiation
.anterograde synaptic vesicle transport
.endosome to melanosome transport
  + 5 more...
.N/A .BLOC-1 complex
.transport vesicle
16 EBI-465804,EBI-2837444 BRK1  
  .positive regulation of Arp2/3 complex-mediated actin nucleation
.protein homotrimerization
.cell motility
  + 9 more...
.protein complex binding .extracellular exosome
.SCAR complex
.lamellipodium
  + 2 more...
17 EBI-465804,EBI-2514791 HAUS1  
  .cell division
.centrosome organization
.spindle assembly
.mitotic nuclear division
.N/A .HAUS complex
.microtubule
.centrosome
  + 2 more...
18 EBI-465804,EBI-2125614 KIFC3  
  .epithelial cell-cell adhesion
.zonula adherens maintenance
.metabolic process
  + 3 more...
.ATPase activity
.ATP binding
.microtubule motor activity
.extracellular exosome
.cytoplasmic vesicle membrane
.zonula adherens
  + 4 more...
19 EBI-465804,EBI-10313866 C19orf66  
  .N/A .N/A .N/A
20 EBI-465804,EBI-465781 BLOC1S6  
  .membrane fusion
.membrane organization
.positive regulation of pigment cell differentiation
  + 12 more...
.actin filament binding
.protein homodimerization activity
.identical protein binding
.syntaxin binding
.BLOC-1 complex
.transport vesicle
.extrinsic component of membrane
  + 4 more...
21 EBI-465804,EBI-712969 CCDC53  
  .protein transport .N/A .WASH complex
.intracellular membrane-bounded organelle
.actin cytoskeleton
.early endosome
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
ascites25
blood40
bone27
brain22
connective tissue134
embryonic tissue18
eye38
heart22
intestine12
kidney14
lung41
lymph45
lymph node66
mammary gland26
mouth15
muscle28
ovary9
pancreas14
parathyroid48
pharynx49
pituitary gland60
placenta21
prostate15
skin18
spleen56
stomach10
testis11
thymus25
thyroid21
tonsil58
uterus34
vascular19
Health State
TissuesTPM*
normal20
breast (mammary gland) tumor42
chondrosarcoma36
gastrointestinal tumor16
germ cell tumor15
glioma37
head and neck tumor14
leukemia63
lung tumor9
lymphoma41
non-neoplasia10
ovarian tumor13
pancreatic tumor9
primitive neuroectodermal tumor of the CNS47
prostate cancer9
retinoblastoma21
skin tumor31
soft tissue/muscle tissue tumor199
uterine tumor11
Developmental Stage
TissuesTPM*
adult32
embryoid body28
fetus14
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue11.5
adrenal gland10.8
appendix18.4
bone marrow12.2
cerebral cortex13.6
colon17
duodenum12.4
esophagus13.2
gallbladder17.2
heart muscle18.9
kidney19
liver5.2
lung15.1
lymph node34.3
ovary13.5
pancreas6.8
placenta17.6
prostate13.4
salivary gland10.1
skin12.9
small intestine15
spleen17.2
stomach13.1
testis12.3
thyroid gland19.2
urinary bladder17.5
Tissues
TissuesExpression level
adrenal glandMedium
appendixHigh
bone marrowLow
breastMedium
bronchusMedium
cerebellumMedium
cerebral cortexMedium
cervix, uterineMedium
colonMedium
duodenumHigh
endometrium 1Medium
endometrium 2Medium
epididymisMedium
fallopian tubeMedium
gallbladderHigh
heart muscleMedium
hippocampusLow
kidneyHigh
lateral ventricleLow
liverLow
lungMedium
lymph nodeHigh
nasopharynxMedium
ovaryLow
pancreasMedium
parathyroid glandHigh
placentaHigh
prostateMedium
rectumHigh
salivary glandLow
seminal vesicleMedium
skeletal muscleLow
skin 1Low
small intestineHigh
smooth muscleLow
soft tissue 1Medium
soft tissue 2Low
spleenHigh
stomach 1High
stomach 2High
testisMedium
thyroid glandMedium
tonsilHigh
urinary bladderMedium
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*607145, gene) Dystrobrevin-binding protein 1; DTNBP1OMIM
2(#614076, phenotype) Hermansky-pudlak syndrome 7; HPS7OMIM


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