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> Protein (NX_Q96EY1)
Protein (NX_Q96EY1)
Protein
Gene SymbolDNAJA3 to neXtProt (NX_Q96EY1)
DescriptionDnaJ homolog subfamily A member 3, mitochondrial
Chromosome16
Location16p13.3 (4475806 ~ 4506776) to Ensembl
Sequene Features : Isoforms 3, Variants 59, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.skeletal muscle acetylcholine-gated channel clustering
.negative regulation of interferon-gamma-mediated signaling pathway
.protein stabilization
  + 23 more...
.chaperone binding
.unfolded protein binding
.NF-kappaB binding
  + 5 more...
.postsynaptic membrane
.intracellular membrane-bounded organelle
.mitochondrial nucleoid
  + 8 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
3 59 5
2014-09-19protein level
3 49 5
2014-05-27protein level
2 47 5
2014-02-25protein level
2 47 5
2013-12-09protein level
2 31 5
2013-11-01protein level
2 29 4
2013-09-12protein level
2 29 3
2013-08-17protein level
2 29 3
2013-07-15protein level
2 18 3
2013-06-11protein level
2 18 3
2013-02-12protein level
2 14 2
2012-12-20protein level
2 15 2
2012-10-30protein level
2 20 2
2012-10-07protein level
2 20 1
2012-08-24protein level
2 20 1
2012-07-28protein level
2 20 1
2012-06-08protein level
2 23 1
2012-05-07protein level
2 17 1
2012-04-10protein level
2 17 1
2012-01-13protein level
2 7 1
2011-12-20protein level
2 7 1
2011-11-11protein level
2 7 1
2011-08-23protein level
2 7 1
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q96EY1-1
2 17 0 52455.3625
NX_Q96EY1-2
0 18 0 49580.0335
NX_Q96EY1-3
2 9 0 33060.4541
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-356767,EBI-710124 KDM1A  
  .positive regulation of stem cell proliferation
.positive regulation of neural precursor cell proliferation
.negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
  + 27 more...
.androgen receptor binding
.flavin adenine dinucleotide binding
.transcription regulatory region DNA binding
  + 13 more...
.transcription factor complex
.nucleoplasm
.nucleus
.nuclear chromatin
2 EBI-3952284,EBI-749295 STK16  
  .cellular response to transforming growth factor beta stimulus
.protein autophosphorylation
.regulation of signal transduction
.ATP binding
.non-membrane spanning protein tyrosine kinase activity
.protein serine/threonine kinase activity
.RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
.perinuclear region of cytoplasm
.membrane
.Golgi-associated vesicle
.cytoplasm
3 EBI-3952284,EBI-1039152 MET  
  .positive regulation of endothelial cell chemotaxis
.negative regulation of hydrogen peroxide-mediated programmed cell death
.semaphorin-plexin signaling pathway
  + 22 more...
.protein phosphatase binding
.ATP binding
.hepatocyte growth factor-activated receptor activity
.protein tyrosine kinase activity
.integral component of membrane
.cell surface
.basal plasma membrane
  + 3 more...
4 EBI-3952284,EBI-3893419 FOSL2  
  .response to cAMP
.response to corticosterone
.positive regulation of fibroblast proliferation
  + 9 more...
.sequence-specific DNA binding transcription factor activity
.double-stranded DNA binding
.RNA polymerase II regulatory region sequence-specific DNA binding
.nucleoplasm
.nucleus
5 EBI-356767,EBI-1186119 STAT5B  
  .cellular response to epidermal growth factor stimulus
.cellular response to growth factor stimulus
.response to interleukin-15
  + 54 more...
.protein dimerization activity
.glucocorticoid receptor binding
.signal transducer activity
  + 4 more...
.cytosol
.cytoplasm
.nucleoplasm
.nucleus
6 EBI-3952284,EBI-10236940 INPP5J  
  .phosphatidylinositol dephosphorylation
.small molecule metabolic process
.inositol phosphate metabolic process
  + 5 more...
.inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity
.inositol-1,4,5-trisphosphate 5-phosphatase activity
.phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity
.inositol-polyphosphate 5-phosphatase activity
.dendritic shaft
.growth cone
.plasma membrane
  + 3 more...
7 EBI-3952284,EBI-739879 ALS2CR11  
  .N/A .N/A .N/A
8 EBI-3952284,EBI-745689 FAM214B  
  .N/A .N/A .nucleus
9 EBI-356767,EBI-2339854 CARM1  
  .endochondral bone morphogenesis
.response to cAMP
.positive regulation of fat cell differentiation
  + 16 more...
.lysine-acetylated histone binding
.transcription regulatory region DNA binding
.histone methyltransferase activity
  + 8 more...
.cytosol
.cytoplasm
.nucleoplasm
.nucleus
10 EBI-3952284,EBI-746252 GCC1  
  .protein targeting to Golgi .N/A .plasma membrane
.Golgi apparatus
.cytoplasm
.Golgi membrane
11 EBI-356767,EBI-912440 PRMT6  
  .negative regulation of transcription, DNA-templated
.histone H4-R3 methylation
.histone H3-R2 methylation
  + 6 more...
.histone methyltransferase activity (H2A-R3 specific)
.histone methyltransferase activity (H3-R2 specific)
.histone methyltransferase activity (H4-R3 specific)
  + 5 more...
.cytosol
.nucleoplasm
.nucleus
12 EBI-3952284,EBI-741729 FRMD6  
  .cellular protein localization
.regulation of actin filament-based process
.apical constriction
.N/A .apical junction complex
.plasma membrane
.cytoskeleton
.cytoplasm
13 EBI-3952284,EBI-395927 NOC4L  
  .rRNA processing
.maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
.poly(A) RNA binding .small-subunit processome
.nuclear membrane
.Noc4p-Nop14p complex
  + 3 more...
14 EBI-3952284,EBI-9057006 OSGIN1  
  .positive regulation of apoptotic process
.negative regulation of cell growth
.cell differentiation
.multicellular organismal development
.growth factor activity .N/A
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue77
adrenal gland30
ascites150
bladder66
blood98
bone97
bone marrow61
brain122
cervix82
connective tissue60
embryonic tissue56
esophagus248
eye23
heart33
intestine90
kidney56
liver43
lung56
lymph90
lymph node55
mammary gland99
mouth120
muscle112
nerve128
ovary147
pancreas60
pharynx73
placenta49
prostate68
salivary gland197
skin75
spleen56
stomach73
testis89
thymus50
thyroid64
tonsil58
trachea19
uterus38
vascular38
Health State
TissuesTPM*
normal66
breast (mammary gland) tumor128
cervical tumor115
chondrosarcoma108
colorectal tumor133
esophageal tumor289
gastrointestinal tumor92
germ cell tumor121
glioma149
head and neck tumor112
kidney tumor43
leukemia105
liver tumor62
lung tumor116
lymphoma96
non-neoplasia41
ovarian tumor170
pancreatic tumor66
primitive neuroectodermal tumor of the CNS133
prostate cancer105
retinoblastoma43
skin tumor87
soft tissue/muscle tissue tumor7
uterine tumor55
Developmental Stage
TissuesTPM*
adult59
embryoid body57
blastocyst81
fetus53
infant42
juvenile125
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue16.7
adrenal gland33.3
appendix21.9
bone marrow8.5
cerebral cortex17.1
colon23.1
duodenum28.2
esophagus23.8
gallbladder16.3
heart muscle34.9
kidney31
liver24.1
lung15.3
lymph node23.4
ovary20.2
pancreas13.6
placenta19.3
prostate18.9
salivary gland20.1
skin21.1
small intestine21.5
spleen19.9
stomach19.5
testis27.1
thyroid gland29.5
urinary bladder21.3
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*608382, gene) Dnaj/hsp40 homolog, subfamily a, member 3; DNAJA3OMIM


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2014-2019 (C) Yonsei Proteome Research Center