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> Protein (NX_Q96EZ8)
Protein (NX_Q96EZ8)
Protein
Gene SymbolMCRS1 to neXtProt (NX_Q96EZ8)
DescriptionMicrospherule protein 1
Chromosome12
Location12q13.12 (49950327 ~ 49961936) to Ensembl
Sequene Features : Isoforms 4, Variants 50, PTMs 10 to neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.histone H4-K16 acetylation
.histone H4-K8 acetylation
.histone H4-K5 acetylation
  + 6 more...
.N/A .MLL1 complex
.Ino80 complex
.cell junction
  + 5 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
4 50 10
2014-09-19protein level
4 38 10
2014-05-27protein level
4 38 10
2014-02-25protein level
3 38 10
2013-12-09protein level
3 27 10
2013-11-01protein level
3 23 10
2013-09-12protein level
3 23 9
2013-08-17protein level
3 23 9
2013-07-15protein level
3 15 8
2013-06-11protein level
3 15 8
2013-02-12protein level
3 4 23
2012-12-20protein level
3 4 23
2012-10-30protein level
3 8 23
2012-10-07protein level
3 8 8
2012-08-24protein level
3 7 8
2012-07-28protein level
3 7 8
2012-06-08protein level
3 8 8
2012-05-07protein level
3 8 8
2012-04-10protein level
3 8 8
2012-01-13protein level
3 4 8
2011-12-20protein level
3 4 8
2011-11-11protein level
3 4 8
2011-08-23protein level
3 4 8
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q96EZ8-1
1 23 0 51771.0519
NX_Q96EZ8-2
2 23 0 52967.6603
NX_Q96EZ8-3
1 23 0 50381.4111
NX_Q96EZ8-4
0 15 0 31114.2519
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-348259,EBI-723574 ZBTB22  
  .regulation of transcription, DNA-templated
.transcription, DNA-templated
.metal ion binding
.DNA binding
.nucleus
2 EBI-348259,EBI-741602 TRIM37  
  .aggresome assembly
.protein autoubiquitination
.positive regulation of NF-kappaB transcription factor activity
  + 7 more...
.ubiquitin protein ligase activity
.protein homodimerization activity
.ubiquitin protein ligase binding
  + 5 more...
.perinuclear region of cytoplasm
.aggresome
.cytosol
  + 2 more...
3 EBI-348259,EBI-745305 IKZF1  
  .retina development in camera-type eye
.positive regulation of NK T cell differentiation
.Peyer's patch development
  + 17 more...
.metal ion binding
.sequence-specific DNA binding
.sequence-specific DNA binding transcription factor activity
.DNA binding
.protein complex
.cytoplasm
.pericentric heterochromatin
.nucleus
4 EBI-348259,EBI-713786 PHC2  
  .cellular protein metabolic process
.post-translational protein modification
.protein sumoylation
  + 2 more...
.identical protein binding
.zinc ion binding
.DNA binding
.PRC1 complex
.PcG protein complex
.nucleoplasm
  + 2 more...
5 EBI-348259,EBI-739895 USHBP1  
  .N/A .PDZ domain binding .N/A
6 EBI-348259,EBI-10181113 KIAA1958  
  .N/A .N/A .N/A
7 EBI-348259,EBI-476263 MAP3K5  
  .cellular response to reactive nitrogen species
.positive regulation of neuron death
.programmed necrotic cell death
  + 18 more...
.protein homodimerization activity
.protein phosphatase binding
.cysteine-type endopeptidase activator activity involved in apoptotic process
  + 4 more...
.IRE1-TRAF2-ASK1 complex
.protein kinase complex
.cytosol
8 EBI-348259,EBI-77321 DAXX  
  .positive regulation of apoptotic signaling pathway
.positive regulation of neuron death
.negative regulation of transcription, DNA-templated
  + 13 more...
.androgen receptor binding
.protein N-terminus binding
.protein homodimerization activity
  + 10 more...
.SWI/SNF superfamily-type complex
.PML body
.cytosol
  + 5 more...
9 EBI-348259,EBI-712969 CCDC53  
  .protein transport .N/A .WASH complex
.intracellular membrane-bounded organelle
.actin cytoskeleton
.early endosome
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adrenal gland60
ascites100
blood163
bone69
bone marrow123
brain70
cervix391
connective tissue13
embryonic tissue93
eye81
heart33
intestine60
kidney28
larynx42
liver38
lung86
lymph45
lymph node33
mammary gland72
muscle112
nerve64
ovary137
pancreas46
placenta95
prostate52
salivary gland148
skin61
stomach73
testis73
thyroid42
umbilical cord72
uterus60
Health State
TissuesTPM*
normal60
adrenal tumor158
breast (mammary gland) tumor64
cervical tumor202
chondrosarcoma60
colorectal tumor62
gastrointestinal tumor126
germ cell tumor56
glioma130
head and neck tumor37
kidney tumor72
leukemia179
liver tumor41
lung tumor165
lymphoma55
non-neoplasia31
ovarian tumor118
pancreatic tumor57
primitive neuroectodermal tumor of the CNS212
prostate cancer77
retinoblastoma43
skin tumor71
soft tissue/muscle tissue tumor151
uterine tumor33
Developmental Stage
TissuesTPM*
adult80
embryoid body57
blastocyst130
neonate32
fetus73
juvenile71
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue22.4
adrenal gland22
appendix32
bone marrow34.5
cerebral cortex24.4
colon29.4
duodenum31.6
esophagus30.5
gallbladder29.5
heart muscle59.6
kidney30.4
liver9.5
lung31.1
lymph node40.8
ovary27.2
pancreas16.7
placenta28.4
prostate25.7
salivary gland23.9
skin35.9
small intestine28.8
spleen31
stomach31.1
testis42.2
thyroid gland46.1
urinary bladder31.1
Tissues
TissuesExpression level
adrenal glandHigh
appendixMedium
bone marrowHigh
breastHigh
bronchusMedium
cerebellumHigh
cerebral cortexHigh
cervix, uterineMedium
colonHigh
duodenumHigh
endometrium 1Medium
endometrium 2Medium
epididymisHigh
esophagusHigh
fallopian tubeHigh
gallbladderHigh
heart muscleMedium
hippocampusMedium
kidneyHigh
lateral ventricleMedium
liverMedium
lungHigh
lymph nodeMedium
nasopharynxHigh
oral mucosaHigh
ovaryHigh
pancreasHigh
parathyroid glandHigh
placentaHigh
prostateHigh
rectumHigh
salivary glandMedium
seminal vesicleHigh
skeletal muscleMedium
skin 1High
skin 2High
small intestineHigh
smooth muscleMedium
soft tissue 1High
soft tissue 2High
spleenMedium
stomach 1Medium
stomach 2Medium
testisHigh
thyroid glandHigh
tonsilMedium
urinary bladderHigh
vaginaHigh
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*609504, gene) Microspherule protein 1; MCRS1OMIM


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