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> Protein (NX_Q96FV9)
Protein (NX_Q96FV9)
Protein
Gene SymbolTHOC1 to neXtProt (NX_Q96FV9)
DescriptionTHO complex subunit 1
Chromosome18
Location18p11.32 (214520 ~ 268050) to Ensembl
Sequene Features : Isoforms 2, Variants 51, PTMs 10 to neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.negative regulation of DNA damage checkpoint
.negative regulation of isotype switching to IgA isotypes
.viral mRNA export from host cell nucleus
  + 11 more...
.RNA binding
.DNA binding
.intercellular bridge
.nuclear speck
.nuclear matrix
  + 6 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
2 51 10
2014-09-19protein level
2 35 10
2014-05-27protein level
2 35 10
2014-02-25protein level
2 34 10
2013-12-09protein level
2 25 10
2013-11-01protein level
2 25 8
2013-09-12protein level
2 25 8
2013-08-17protein level
2 25 8
2013-07-15protein level
2 19 8
2013-06-11protein level
2 19 8
2013-02-12protein level
2 5 8
2012-12-20protein level
2 5 8
2012-10-30protein level
2 9 8
2012-10-07protein level
2 9 5
2012-08-24protein level
2 6 5
2012-07-28protein level
2 6 6
2012-06-08protein level
2 11 6
2012-05-07protein level
2 11 6
2012-04-10protein level
2 11 6
2012-01-13protein level
3 10 5
2011-12-20protein level
3 10 5
2011-11-11protein level
3 10 4
2011-08-23protein level
3 10 4
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q96FV9-1
19 16 0 75618.3293
NX_Q96FV9-2
1 16 0 43331.6888
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-1765605,EBI-5280316 THOC5  
  .regulation of stem cell division
.negative regulation of DNA damage checkpoint
.primitive hemopoiesis
  + 11 more...
.mRNA binding .nuclear speck
.cytoplasm
.nucleoplasm
  + 4 more...
2 EBI-1765605,EBI-739895 USHBP1  
  .N/A .PDZ domain binding .N/A
3 EBI-1765605,EBI-739825 MOAP1  
  .extrinsic apoptotic signaling pathway in absence of ligand
.apoptotic signaling pathway
.positive regulation of release of cytochrome c from mitochondria
  + 4 more...
.ubiquitin protein ligase binding .cytosol
.mitochondrial outer membrane
.mitochondrion
.cytoplasm
4 EBI-1765605,EBI-2130429 TRIM54  
  .cell differentiation
.multicellular organismal development
.signal transduction
  + 2 more...
.zinc ion binding
.signal transducer activity
.Z disc
.microtubule associated complex
.microtubule
5 EBI-1765605,EBI-913954 RABGEF1  
  .negative regulation of Kit signaling pathway
.negative regulation of interleukin-6 secretion
.regulation of Fc receptor mediated stimulatory signaling pathway
  + 9 more...
.Rab GTPase binding
.Rab guanyl-nucleotide exchange factor activity
.zinc ion binding
  + 2 more...
.recycling endosome
.vesicle
.early endosome
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adrenal gland30
bladder33
blood49
bone41
bone marrow102
brain38
cervix41
connective tissue154
ear62
embryonic tissue56
eye28
heart11
intestine4
kidney23
larynx213
liver48
lung47
lymph node122
mammary gland6
muscle28
nerve64
ovary49
pharynx24
placenta28
prostate36
skin4
spleen74
stomach52
testis73
thymus25
thyroid64
uterus56
vascular19
Health State
TissuesTPM*
normal36
adrenal tumor79
breast (mammary gland) tumor10
chondrosarcoma12
gastrointestinal tumor8
germ cell tumor41
head and neck tumor59
kidney tumor14
leukemia52
liver tumor31
lung tumor68
lymphoma13
non-neoplasia41
ovarian tumor39
primitive neuroectodermal tumor of the CNS110
prostate cancer48
retinoblastoma64
soft tissue/muscle tissue tumor143
uterine tumor44
Developmental Stage
TissuesTPM*
adult44
embryoid body14
blastocyst65
fetus62
infant42
juvenile35
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue15.7
adrenal gland19.3
appendix26.7
bone marrow45.3
cerebral cortex17.7
colon16.8
duodenum18.7
esophagus14
gallbladder18.5
heart muscle11.2
kidney15.1
liver10
lung19.4
lymph node33.3
ovary26
pancreas9.7
placenta19.6
prostate24.7
salivary gland15.4
skin34.5
small intestine19.8
spleen25.1
stomach16.9
testis35.6
thyroid gland24.8
urinary bladder20
Tissues
TissuesExpression level
adrenal glandLow
appendixMedium
bone marrowMedium
breastLow
bronchusLow
cerebellumMedium
cerebral cortexHigh
colonMedium
duodenumMedium
epididymisLow
esophagusLow
gallbladderHigh
heart muscleMedium
hippocampusMedium
kidneyMedium
lateral ventricleMedium
lungMedium
lymph nodeLow
nasopharynxMedium
oral mucosaMedium
ovaryLow
pancreasMedium
parathyroid glandLow
placentaMedium
prostateLow
rectumMedium
seminal vesicleLow
skeletal muscleLow
skin 2Medium
small intestineMedium
smooth muscleLow
stomach 1Low
stomach 2Low
testisMedium
thyroid glandMedium
tonsilMedium
urinary bladderMedium
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*606930, gene) Tho complex, subunit 1; THOC1OMIM


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