Home| Contact Us

HOME SEARCH STATISTICS
> Protein (NX_Q96FW1)
Protein (NX_Q96FW1)
Protein
Gene SymbolOTUB1 to neXtProt (NX_Q96FW1)
DescriptionUbiquitin thioesterase OTUB1
Chromosome11
Location11q13.1 (63753325 ~ 63769283) to Ensembl
Sequene Features : Isoforms 2, Variants 27, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.negative regulation of double-strand break repair
.negative regulation of histone H2A K63-linked ubiquitination
.protein K48-linked deubiquitination
  + 3 more...
.ubiquitin binding
.ubiquitin protein ligase binding
.NEDD8-specific protease activity
.ubiquitin-specific protease activity
.extracellular exosome
.cytoplasm
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
2 27 7
2014-09-19protein level
2 20 7
2014-05-27protein level
2 18 7
2014-02-25protein level
2 18 7
2013-12-09protein level
2 14 7
2013-11-01protein level
2 13 5
2013-09-12protein level
2 13 5
2013-08-17protein level
2 13 5
2013-07-15protein level
2 4 1
2013-06-11protein level
2 4 1
2013-02-12protein level
2 2 4
2012-12-20protein level
2 4 4
2012-10-30protein level
2 5 4
2012-10-07protein level
2 5 3
2012-08-24protein level
2 5 3
2012-07-28protein level
2 5 3
2012-06-08protein level
2 15 3
2012-05-07protein level
2 14 3
2012-04-10protein level
2 14 3
2012-01-13protein level
2 14 3
2011-12-20protein level
2 14 3
2011-11-11protein level
2 14 3
2011-08-23protein level
2 14 3
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q96FW1-1
7 8 0 31264.3306
NX_Q96FW1-2
6 8 0 35262.4759
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-1058491,EBI-366083 TP53  
  .positive regulation of intrinsic apoptotic signaling pathway
.positive regulation of reactive oxygen species metabolic process
.negative regulation of reactive oxygen species metabolic process
  + 99 more...
.protein phosphatase 2A binding
.chaperone binding
.protein N-terminus binding
  + 27 more...
.protein complex
.PML body
.nuclear matrix
  + 11 more...
2 EBI-1058491,EBI-743540 UBE2D1  
  .cellular response to hypoxia
.protein K48-linked ubiquitination
.regulation of transcription from RNA polymerase II promoter in response to hypoxia
  + 22 more...
.ubiquitin conjugating enzyme activity
.ligase activity
.ATP binding
.ubiquitin-protein transferase activity
.protein complex
.cytosol
.cytoplasm
  + 2 more...
3 EBI-1058491,EBI-348268 UBE2D3  
  .positive regulation of protein targeting to mitochondrion
.cellular response to hypoxia
.protein K11-linked ubiquitination
  + 24 more...
.ubiquitin conjugating enzyme activity
.ligase activity
.ATP binding
.ubiquitin-protein transferase activity
.extracellular exosome
.endosome membrane
.plasma membrane
  + 2 more...
4 EBI-1058491,EBI-347677 UBE2D2  
  .cellular response to hypoxia
.protein K48-linked ubiquitination
.regulation of transcription from RNA polymerase II promoter in response to hypoxia
  + 12 more...
.ubiquitin conjugating enzyme activity
.ligase activity
.ATP binding
.ubiquitin-protein transferase activity
.extracellular exosome
.protein complex
.cytosol
  + 2 more...
5 EBI-1058491,EBI-389668 MDM2  
  .negative regulation of signal transduction by p53 class mediator
.cellular response to UV-C
.cellular response to hypoxia
  + 44 more...
.ubiquitin protein ligase activity
.identical protein binding
.ubiquitin protein ligase binding
  + 5 more...
.synapse
.protein complex
.endocytic vesicle membrane
  + 6 more...
6 EBI-1058491,EBI-514538 BIRC2  
  .regulation of reactive oxygen species metabolic process
.regulation of cysteine-type endopeptidase activity
.inhibition of cysteine-type endopeptidase activity involved in apoptotic process
  + 40 more...
.protein N-terminus binding
.cysteine-type endopeptidase inhibitor activity involved in apoptotic process
.ligase activity
  + 3 more...
.membrane raft
.CD40 receptor complex
.cytoplasmic side of plasma membrane
  + 4 more...
7 EBI-1058491,EBI-745527 UBE2D4  
  .protein K6-linked ubiquitination
.protein K11-linked ubiquitination
.protein K48-linked ubiquitination
  + 4 more...
.ubiquitin conjugating enzyme activity
.ligase activity
.ATP binding
.ubiquitin-protein transferase activity
.N/A
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adrenal gland91
ascites326
bladder100
blood147
bone111
bone marrow82
brain278
cervix247
connective tissue67
embryonic tissue253
esophagus297
eye143
heart134
intestine245
kidney156
liver77
lung167
lymph112
lymph node44
mammary gland138
mouth45
muscle84
nerve128
ovary197
pancreas60
pharynx98
pituitary gland60
placenta180
prostate73
salivary gland98
skin147
spleen149
stomach156
testis112
thymus200
thyroid128
tonsil235
umbilical cord290
uterus150
vascular58
Health State
TissuesTPM*
normal181
adrenal tumor158
breast (mammary gland) tumor182
cervical tumor260
chondrosarcoma96
colorectal tumor231
esophageal tumor347
gastrointestinal tumor219
germ cell tumor151
glioma167
head and neck tumor67
kidney tumor232
leukemia42
liver tumor72
lung tumor291
lymphoma138
non-neoplasia175
ovarian tumor210
pancreatic tumor85
primitive neuroectodermal tumor of the CNS472
prostate cancer67
retinoblastoma107
skin tumor143
soft tissue/muscle tissue tumor167
uterine tumor155
Developmental Stage
TissuesTPM*
adult150
embryoid body185
blastocyst260
neonate257
fetus120
infant255
juvenile107
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue31.6
adrenal gland40
appendix46.5
bone marrow47.3
cerebral cortex62.7
colon42.7
duodenum40.1
esophagus58.7
gallbladder41.6
heart muscle43.3
kidney43.8
liver19.1
lung42.3
lymph node62.6
ovary37.5
pancreas20.3
placenta51.6
prostate42.8
salivary gland42.8
skin57.2
small intestine39.3
spleen45.5
stomach40.7
testis48
thyroid gland53.6
urinary bladder52.9
Tissues
TissuesExpression level
adrenal glandMedium
appendixMedium
bone marrowLow
breastMedium
bronchusMedium
cerebellumMedium
cerebral cortexMedium
cervix, uterineMedium
colonMedium
duodenumMedium
endometrium 1Medium
endometrium 2Medium
epididymisMedium
esophagusMedium
fallopian tubeMedium
gallbladderMedium
heart muscleLow
hippocampusMedium
kidneyMedium
lateral ventricleMedium
liverLow
lungMedium
lymph nodeMedium
nasopharynxMedium
oral mucosaLow
ovaryHigh
pancreasLow
parathyroid glandLow
placentaLow
prostateLow
rectumMedium
salivary glandMedium
seminal vesicleLow
skeletal muscleLow
skin 1Low
skin 2Medium
small intestineMedium
smooth muscleMedium
soft tissue 1Low
soft tissue 2Low
spleenMedium
stomach 1Medium
stomach 2Medium
testisMedium
thyroid glandMedium
tonsilMedium
urinary bladderMedium
vaginaMedium
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*608337, gene) Otu domain-containing ubiquitin aldehyde-binding protein 1; OTUB1OMIM


#424, YPRC/BPRC, Industry-University Research Center, Yonsei Univ., Seodaemun-gu, Seoul, Korea, 120-749
Tel: +82-2-2123-6626, Fax: +82-2-393-6589
2014-2019 (C) Yonsei Proteome Research Center