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> Protein (NX_Q96G25)
Protein (NX_Q96G25)
Protein
Gene SymbolMED8 to neXtProt (NX_Q96G25)
DescriptionMediator of RNA polymerase II transcription subunit 8
Chromosome1
Location1p34.2 (43849588 ~ 43855479) to Ensembl
Sequene Features : Isoforms 3, Variants 33, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.protein ubiquitination
.gene expression
.transcription initiation from RNA polymerase II promoter
.RNA polymerase II transcription cofactor activity .mediator complex
.nucleoplasm
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
3 33 1
2014-09-19protein level
3 23 1
2014-05-27protein level
3 23 1
2014-02-25protein level
3 23 1
2013-12-09protein level
3 16 1
2013-11-01protein level
3 16 1
2013-09-12protein level
3 16 1
2013-08-17protein level
3 16 1
2013-07-15protein level
3 13 1
2013-06-11protein level
3 13 1
2013-02-12protein level
3 7 2
2012-12-20protein level
3 7 2
2012-10-30protein level
3 9 2
2012-10-07protein level
3 9 1
2012-08-24protein level
3 6 1
2012-07-28protein level
3 6 1
2012-06-08protein level
3 9 1
2012-05-07protein level
3 9 1
2012-04-10protein level
3 9 1
2012-01-13protein level
3 8 1
2011-12-20protein level
3 8 1
2011-11-11protein level
3 8 1
2011-08-23protein level
3 8 1
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q96G25-1
0 13 0 29061.754
NX_Q96G25-2
1 12 0 32797.9392
NX_Q96G25-3
0 9 0 18990.4545
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-394405,EBI-301231 TCEB1  
  .cellular response to hypoxia
.regulation of transcription from RNA polymerase II promoter in response to hypoxia
.positive regulation of viral transcription
  + 7 more...
.N/A .elongin complex
.cytosol
.nucleoplasm
2 EBI-394405,EBI-301238 TCEB2  
  .cellular response to hypoxia
.regulation of transcription from RNA polymerase II promoter in response to hypoxia
.positive regulation of viral transcription
  + 6 more...
.ubiquitin protein ligase binding .elongin complex
.extracellular exosome
.Cul5-RING ubiquitin ligase complex
  + 4 more...
3 EBI-10286267,EBI-10171697 KRT40  
  .N/A .structural molecule activity .intermediate filament
4 EBI-10286267,EBI-302345 PNMA1  
  .positive regulation of apoptotic process
.inflammatory response to antigenic stimulus
.N/A .focal adhesion
.cytoplasm
.nucleolus
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
ascites75
bladder66
blood106
bone97
brain30
cervix41
connective tissue93
embryonic tissue18
eye71
heart67
intestine51
kidney42
larynx42
liver97
lung23
lymph45
mammary gland33
muscle47
ovary108
pancreas23
pituitary gland60
placenta35
prostate52
salivary gland98
skin56
stomach125
testis43
thymus12
thyroid21
uterus77
vascular19
Health State
TissuesTPM*
normal40
breast (mammary gland) tumor21
cervical tumor57
chondrosarcoma156
colorectal tumor35
gastrointestinal tumor92
germ cell tumor18
glioma93
head and neck tumor22
kidney tumor72
leukemia74
liver tumor135
lung tumor19
lymphoma27
non-neoplasia20
ovarian tumor131
pancreatic tumor28
primitive neuroectodermal tumor of the CNS7
prostate cancer77
retinoblastoma86
skin tumor63
soft tissue/muscle tissue tumor23
uterine tumor66
Developmental Stage
TissuesTPM*
adult69
embryoid body28
blastocyst32
fetus35
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue19.9
adrenal gland16.5
appendix22
bone marrow17.8
cerebral cortex14.6
colon23
duodenum22.4
esophagus25.7
gallbladder18.8
heart muscle11.5
kidney18.9
liver17.5
lung18.1
lymph node22.9
ovary18.8
pancreas11
placenta26
prostate18.6
salivary gland19.5
skin21.8
small intestine19.8
spleen16.8
stomach23.4
testis22.4
thyroid gland26.9
urinary bladder22.5
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*607956, gene) Mediator complex subunit 8; MED8OMIM


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