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> Protein (NX_Q96GF1)
Protein (NX_Q96GF1)
Protein
Gene SymbolRNF185 to neXtProt (NX_Q96GF1)
DescriptionE3 ubiquitin-protein ligase RNF185
Chromosome22
Location22q12.2 (31556168 ~ 31603005) to Ensembl
Sequene Features : Isoforms 2, Variants 18, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.protein ubiquitination
.autophagy
.ligase activity
.zinc ion binding
.integral component of membrane
.endoplasmic reticulum membrane
.mitochondrial outer membrane
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
2 18 2
2014-09-19protein level
2 16 2
2014-05-27protein level
2 16 2
2014-02-25protein level
2 16 2
2013-12-09protein level
2 12 2
2013-11-01protein level
2 12 1
2013-09-12protein level
2 12 1
2013-08-17protein level
2 12 1
2013-07-15protein level
2 10 0
2013-06-11protein level
2 10 0
2013-02-12protein level
2 3 0
2012-12-20protein level
2 3 0
2012-10-30protein level
2 4 0
2012-10-07protein level
2 4 0
2012-08-24protein level
2 4 0
2012-07-28protein level
2 4 0
2012-06-08protein level
2 4 0
2012-05-07protein level
2 3 0
2012-04-10protein level
2 3 0
2012-01-13protein level
2 2 0
2011-12-20protein level
2 2 0
2011-11-11protein level
2 2 0
2011-08-23transcript level
2 2 0
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q96GF1-1
4 2 0 20445.8742
NX_Q96GF1-2
1 2 0 14129.6459
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-2340249,EBI-2860752 ARL6IP5  
  .negative regulation of transport
.positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
.positive regulation of apoptotic process
  + 4 more...
.N/A .extracellular exosome
.integral component of membrane
.membrane
  + 2 more...
2 EBI-2340249,EBI-348496 UBE2E3  
  .protein K11-linked ubiquitination
.protein K48-linked ubiquitination
.protein K63-linked ubiquitination
.regulation of growth
.ligase activity
.ATP binding
.ubiquitin-protein transferase activity
.cytoplasm
.nucleus
3 EBI-2340249,EBI-2548702 CMTM5  
  .negative regulation of myoblast differentiation
.chemotaxis
.N/A .integral component of membrane
.extracellular space
4 EBI-2340249,EBI-348482 RNF5  
  .regulation of autophagic vacuole assembly
.ER-associated misfolded protein catabolic process
.protein K48-linked ubiquitination
  + 5 more...
.ligase activity
.zinc ion binding
.ubiquitin-protein transferase activity
.mitochondrial membrane
.integral component of membrane
.endoplasmic reticulum membrane
5 EBI-2340249,EBI-751253 YIPF4  
  .N/A .N/A .intracellular membrane-bounded organelle
.integral component of membrane
.plasma membrane
  + 2 more...
6 EBI-2340249,EBI-751204 YIPF2  
  .N/A .N/A .transport vesicle
.integral component of membrane
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
ascites100
blood122
bone41
bone marrow20
brain155
cervix61
connective tissue107
embryonic tissue75
esophagus99
eye76
heart89
intestine73
kidney75
larynx42
liver24
lung59
lymph90
lymph node22
mammary gland66
mouth151
muscle56
nerve64
ovary49
pancreas74
parathyroid339
pharynx24
placenta173
prostate110
salivary gland148
skin94
spleen74
stomach73
testis107
thymus351
thyroid107
tonsil58
trachea251
umbilical cord72
uterus77
vascular58
Health State
TissuesTPM*
normal100
breast (mammary gland) tumor10
cervical tumor57
chondrosarcoma72
colorectal tumor71
esophageal tumor115
gastrointestinal tumor75
germ cell tumor167
glioma149
head and neck tumor127
kidney tumor101
leukemia127
liver tumor41
lung tumor48
lymphoma55
non-neoplasia134
ovarian tumor52
pancreatic tumor76
primitive neuroectodermal tumor of the CNS70
prostate cancer48
retinoblastoma86
skin tumor23
soft tissue/muscle tissue tumor79
uterine tumor66
Developmental Stage
TissuesTPM*
adult82
embryoid body71
blastocyst16
neonate225
fetus156
infant85
juvenile125
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue16.9
adrenal gland17.6
appendix13.8
bone marrow6.9
cerebral cortex16
colon19.4
duodenum17.4
esophagus22.8
gallbladder17.7
heart muscle15.8
kidney28
liver19.1
lung17.2
lymph node15
ovary24.6
pancreas9.2
placenta20.7
prostate30.3
salivary gland22.1
skin22.3
small intestine18.7
spleen12.2
stomach15
testis12.5
thyroid gland52.6
urinary bladder19.8
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected


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