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> Protein (NX_Q96GN5)
Protein (NX_Q96GN5)
Protein
Gene SymbolCDCA7L to neXtProt (NX_Q96GN5)
DescriptionCell division cycle-associated 7-like protein
Chromosome7
Location7p15.3 (21940518 ~ 21985702) to Ensembl
Sequene Features : Isoforms 4, Variants 63, PTMs 20 to neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.positive regulation of cell proliferation
.regulation of transcription, DNA-templated
.transcription, DNA-templated
.N/A .cytoplasm
.nucleolus
.nucleus
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
4 63 20
2014-09-19protein level
4 51 20
2014-05-27protein level
4 51 20
2014-02-25protein level
4 51 20
2013-12-09protein level
4 42 20
2013-11-01protein level
4 40 20
2013-09-12protein level
4 40 20
2013-08-17protein level
4 40 20
2013-07-15protein level
4 27 16
2013-06-11protein level
4 27 16
2013-02-12protein level
3 13 50
2012-12-20protein level
3 13 50
2012-10-30protein level
3 15 50
2012-10-07protein level
3 15 17
2012-08-24protein level
3 6 17
2012-07-28protein level
3 6 17
2012-06-08protein level
3 8 17
2012-05-07protein level
2 8 17
2012-04-10protein level
2 8 17
2012-01-13protein level
2 4 17
2011-12-20protein level
2 4 17
2011-11-11protein level
2 4 15
2011-08-23protein level
2 4 15
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q96GN5-1
0 21 1 52173.4061
NX_Q96GN5-2
0 21 1 52045.3479
NX_Q96GN5-4
1 19 1 48278.5755
NX_Q96GN5-5
1 19 1 46749.8891
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-5278764,EBI-742268 TADA2A  
  .histone H3 acetylation
.transcription from RNA polymerase II promoter
.regulation of transcription from RNA polymerase II promoter
.chromatin organization
.zinc ion binding
.transcription cofactor activity
.sequence-specific DNA binding transcription factor activity
  + 2 more...
.chromosome
.nucleus
.PCAF complex
2 EBI-5278764,EBI-740865 ZNF821  
  .regulation of transcription, DNA-templated
.transcription, DNA-templated
.metal ion binding
.DNA binding
.nucleus
3 EBI-5278764,EBI-714135 STX11  
  .membrane fusion
.vesicle docking
.natural killer cell degranulation
  + 4 more...
.SNAP receptor activity
.SNARE binding
.SNARE complex
.integral component of membrane
.endomembrane system
  + 3 more...
4 EBI-5278764,EBI-356983 UBL4A  
  .tail-anchored membrane protein insertion into ER membrane
.transport
.cellular protein modification process
.ubiquitin-like protein transferase activity .BAT3 complex
.cytosol
5 EBI-5278764,EBI-10177272 ZNF250  
  .regulation of transcription, DNA-templated
.transcription, DNA-templated
.metal ion binding
.sequence-specific DNA binding transcription factor activity
.DNA binding
.nucleus
6 EBI-5278764,EBI-8639312 LMO1  
  .positive regulation of transcription from RNA polymerase II promoter
.negative regulation of transcription from RNA polymerase II promoter
.zinc ion binding .nucleus
7 EBI-5278764,EBI-299104 EIF4A3  
  .mRNA transport
.embryonic cranial skeleton morphogenesis
.positive regulation of translation
  + 10 more...
.poly(A) RNA binding
.poly(A) binding
.ATP binding
  + 2 more...
.catalytic step 2 spliceosome
.exon-exon junction complex
.nuclear speck
  + 5 more...
8 EBI-5278764,EBI-356811 NOP2  
  .positive regulation of cell proliferation
.rRNA processing
.poly(A) RNA binding
.S-adenosylmethionine-dependent methyltransferase activity
.nucleolus
9 EBI-5278764,EBI-1048159 MFAP1  
  .extracellular matrix organization .poly(A) RNA binding .extracellular region
.microfibril
10 EBI-5278764,EBI-10172290 KRTAP10-7  
  .N/A .identical protein binding .keratin filament
11 EBI-5278764,EBI-358049 BYSL  
  .cell proliferation
.female pregnancy
.cell adhesion
  + 2 more...
.poly(A) RNA binding .apical part of cell
.intracellular membrane-bounded organelle
.membrane
  + 3 more...
12 EBI-5278764,EBI-9675802 MORN3  
  .N/A .N/A .nucleus
13 EBI-9091443,EBI-524753 ZDHHC17  
  .positive regulation of I-kappaB kinase/NF-kappaB signaling
.lipoprotein transport
.protein palmitoylation
  + 2 more...
.identical protein binding
.protein-cysteine S-palmitoyltransferase activity
.palmitoyltransferase activity
  + 3 more...
.intracellular membrane-bounded organelle
.Golgi-associated vesicle membrane
.integral component of membrane
  + 3 more...
14 EBI-5278764,EBI-10175124 FAM9B  
  .spermatid development .N/A .nucleoplasm
15 EBI-5278764,EBI-10181188 BEND7  
  .N/A .N/A .extracellular exosome
16 EBI-5278764,EBI-739624 CEP70  
  .organelle organization
.mitotic cell cycle
.G2/M transition of mitotic cell cycle
.N/A .nuclear membrane
.cytosol
.centrosome
  + 2 more...
17 EBI-5278764,EBI-748128 CTNNBL1  
  .positive regulation of apoptotic process
.somatic diversification of immunoglobulins
.gene expression
  + 3 more...
.enzyme binding .membrane
.cytoplasm
.spliceosomal complex
  + 3 more...
18 EBI-5278764,EBI-488533 ING5  
  .positive regulation of apoptotic signaling pathway
.negative regulation of growth
.positive regulation of transcription, DNA-templated
  + 7 more...
.methylated histone binding
.zinc ion binding
.chromatin binding
.MOZ/MORF histone acetyltransferase complex
.nucleoplasm
.nucleus
19 EBI-5278764,EBI-10293968 PPP1R16B  
  .positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis
.negative regulation of peptidyl-serine dephosphorylation
.establishment of endothelial barrier
  + 6 more...
.protein phosphatase type 1 regulator activity .perinuclear region of cytoplasm
.cell projection
.plasma membrane
.nucleus
20 EBI-5278764,EBI-724076 MDFI  
  .trophoblast giant cell differentiation
.embryonic skeletal system morphogenesis
.negative regulation of DNA binding
  + 6 more...
.N/A .cytoplasm
.nucleus
21 EBI-5278764,EBI-3957793 PRDM14  
  .homeostasis of number of cells within a tissue
.regulation of DNA methylation
.negative regulation of fibroblast growth factor receptor signaling pathway
  + 11 more...
.metal ion binding
.methyltransferase activity
.DNA binding
.nucleoplasm
22 EBI-5278764,EBI-751319 CARD9  
  .nucleotide-binding oligomerization domain containing signaling pathway
.defense response to virus
.defense response to Gram-positive bacterium
  + 17 more...
.CARD domain binding
.protein homodimerization activity
.plasma membrane
.cytosol
.cytoplasm
23 EBI-5278764,EBI-714067 UTP3  
  .chromatin modification
.brain development
.maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
.poly(A) RNA binding .small-subunit processome
.nucleolus
.nucleus
24 EBI-5278764,EBI-77321 DAXX  
  .positive regulation of apoptotic signaling pathway
.positive regulation of neuron death
.negative regulation of transcription, DNA-templated
  + 13 more...
.androgen receptor binding
.protein N-terminus binding
.protein homodimerization activity
  + 10 more...
.SWI/SNF superfamily-type complex
.PML body
.cytosol
  + 5 more...
25 EBI-5278764,EBI-2602396 ABT1  
  .small-subunit processome assembly
.spinal cord motor neuron differentiation
.transcription from RNA polymerase II promoter
  + 4 more...
.poly(A) RNA binding
.transcription coactivator activity
.DNA binding
.nucleotide binding
.nucleolus
.transcription factor complex
.nucleus
26 EBI-5278764,EBI-765817 TRAF3IP3  
  .N/A .N/A .integral component of membrane
27 EBI-5278764,EBI-2212028 SSX2IP  
  .regulation of cell motility
.centrosome organization
.cilium assembly
  + 3 more...
.N/A .protein complex
.ciliary basal body
.centriolar satellite
  + 3 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue155
ascites25
bladder100
blood196
bone27
bone marrow41
brain39
cervix82
connective tissue33
ear124
embryonic tissue23
esophagus99
eye28
heart22
intestine51
kidney23
larynx42
liver58
lung23
lymph135
lymph node55
mammary gland46
mouth120
muscle28
ovary49
pancreas14
parathyroid48
placenta28
prostate42
skin47
spleen112
stomach31
testis213
thymus690
thyroid42
trachea19
umbilical cord217
uterus51
vascular77
Health State
TissuesTPM*
normal45
breast (mammary gland) tumor53
cervical tumor115
chondrosarcoma36
colorectal tumor44
esophageal tumor115
gastrointestinal tumor33
germ cell tumor349
glioma37
head and neck tumor67
kidney tumor29
leukemia148
liver tumor83
lung tumor38
lymphoma124
non-neoplasia20
ovarian tumor26
pancreatic tumor28
primitive neuroectodermal tumor of the CNS118
prostate cancer38
retinoblastoma107
skin tumor7
soft tissue/muscle tissue tumor23
uterine tumor77
Developmental Stage
TissuesTPM*
adult69
embryoid body14
blastocyst32
neonate225
fetus1
infant127
juvenile323
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue4.8
adrenal gland1.9
appendix15.3
bone marrow37.3
cerebral cortex5.6
colon16.6
duodenum10.2
esophagus12.1
gallbladder9.4
heart muscle23.6
kidney3.2
liver3.4
lung15.5
lymph node34.8
ovary24.7
pancreas7
placenta3.9
prostate6.9
salivary gland7.7
skin20
small intestine13
spleen15.8
stomach17.2
testis22.2
thyroid gland31.2
urinary bladder11
Tissues
TissuesExpression level
adrenal glandMedium
appendixHigh
bone marrowMedium
breastLow
bronchusLow
cerebellumMedium
cerebral cortexMedium
cervix, uterineLow
colonHigh
duodenumMedium
endometrium 1Low
endometrium 2Low
epididymisLow
fallopian tubeLow
gallbladderMedium
kidneyMedium
lungLow
lymph nodeHigh
nasopharynxMedium
oral mucosaLow
pancreasLow
parathyroid glandMedium
placentaMedium
rectumMedium
salivary glandLow
small intestineMedium
soft tissue 1Low
soft tissue 2Low
spleenLow
stomach 1Medium
stomach 2Medium
testisHigh
thyroid glandLow
tonsilHigh
urinary bladderMedium
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*609685, gene) Cell division cycle-associated protein 7-like; CDCA7LOMIM


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