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> Protein (NX_Q96GX9)
Protein (NX_Q96GX9)
Protein
Gene SymbolAPIP to neXtProt (NX_Q96GX9)
DescriptionMethylthioribulose-1-phosphate dehydratase
Chromosome11
Location11p13 (34874641 ~ 34938046) to Ensembl
Sequene Features : Isoforms 2, Variants 30, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.regulation of ERK1 and ERK2 cascade
.small molecule metabolic process
.negative regulation of apoptotic process
  + 6 more...
.methylthioribulose 1-phosphate dehydratase activity
.identical protein binding
.zinc ion binding
.cytoplasm
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
2 30 4
2014-09-19protein level
2 26 4
2014-05-27protein level
2 25 4
2014-02-25protein level
2 25 4
2013-12-09protein level
2 16 4
2013-11-01protein level
2 16 4
2013-09-12protein level
2 16 4
2013-08-17protein level
2 16 4
2013-07-15protein level
2 11 3
2013-06-11protein level
2 11 3
2013-02-12protein level
2 8 4
2012-12-20protein level
2 8 4
2012-10-30protein level
2 9 4
2012-10-07protein level
1 9 2
2012-08-24protein level
1 8 2
2012-07-28protein level
1 8 2
2012-06-08protein level
1 10 2
2012-05-07protein level
1 10 2
2012-04-10protein level
1 10 2
2012-01-13protein level
1 7 2
2011-12-20protein level
1 7 2
2011-11-11protein level
1 7 1
2011-08-23protein level
1 7 1
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q96GX9-1
3 12 0 27107.1448
NX_Q96GX9-3
2 12 0 22843.2494
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-359248,EBI-727004 SDCBP  
  .positive regulation of extracellular exosome assembly
.positive regulation of exosomal secretion
.ephrin receptor signaling pathway
  + 9 more...
.protein N-terminus binding
.protein heterodimerization activity
.syndecan binding
  + 4 more...
.blood microparticle
.extracellular exosome
.melanosome
  + 12 more...
2 EBI-359248,EBI-431907 TNPO2  
  .intracellular protein transport .nuclear localization sequence binding .cytoplasm
.nucleus
3 EBI-359248,EBI-353389 IMPDH2  
  .cellular response to interleukin-4
.retina development in camera-type eye
.nucleobase-containing small molecule metabolic process
  + 6 more...
.metal ion binding
.IMP dehydrogenase activity
.RNA binding
  + 2 more...
.extracellular exosome
.membrane
.cytosol
  + 3 more...
4 EBI-359248,EBI-739899 ZBTB25  
  .gene expression
.transcription from RNA polymerase II promoter
.regulation of transcription from RNA polymerase II promoter
.metal ion binding
.sequence-specific DNA binding transcription factor activity
.DNA binding
.RNA polymerase II regulatory region sequence-specific DNA binding
.cytoplasm
.nucleoplasm
5 EBI-359248,EBI-359352 PSMA1  
  .positive regulation of canonical Wnt signaling pathway
.negative regulation of canonical Wnt signaling pathway
.regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
  + 23 more...
.threonine-type endopeptidase activity
.endopeptidase activity
.RNA binding
.extracellular exosome
.proteasome core complex, alpha-subunit complex
.polysome
  + 7 more...
6 EBI-359248,EBI-307486 SKP1  
  .regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
.positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition
.innate immune response
  + 11 more...
.ubiquitin-protein transferase activity .extracellular exosome
.Cul7-RING ubiquitin ligase complex
.SCF ubiquitin ligase complex
  + 2 more...
7 EBI-359248,EBI-740486 NUDT18  
  .nucleobase-containing small molecule metabolic process
.GDP catabolic process
.dGDP catabolic process
  + 3 more...
.8-hydroxy-dADP phosphatase activity
.8-oxo-GDP phosphatase activity
.8-oxo-dGDP phosphatase activity
.magnesium ion binding
.cytosol
8 EBI-359248,EBI-749051 C6orf165  
  .N/A .N/A .N/A
9 EBI-359248,EBI-739832 LNX1  
  .protein homooligomerization
.protein ubiquitination involved in ubiquitin-dependent protein catabolic process
.ligase activity
.zinc ion binding
.ubiquitin-protein transferase activity
.cytoplasm
10 EBI-359248,EBI-741158 WDYHV1  
  .cellular protein modification process .protein-N-terminal glutamine amidohydrolase activity .cytosol
.nucleus
11 EBI-359248,EBI-739485 TSC22D4  
  .negative regulation of transcription, DNA-templated
.transcription, DNA-templated
.sequence-specific DNA binding transcription factor activity .nucleus
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue77
adrenal gland121
ascites225
bladder33
blood57
bone13
bone marrow102
brain34
connective tissue73
embryonic tissue9
eye52
heart11
intestine25
kidney42
liver29
lung29
lymph22
lymph node33
mammary gland6
mouth45
muscle28
nerve64
ovary9
pancreas60
pharynx24
placenta10
prostate31
salivary gland197
skin37
stomach31
testis29
thymus25
tonsil117
umbilical cord145
uterus12
vascular96
Health State
TissuesTPM*
normal29
adrenal tumor158
bladder carcinoma113
breast (mammary gland) tumor10
chondrosarcoma24
colorectal tumor44
gastrointestinal tumor92
germ cell tumor15
glioma27
head and neck tumor22
kidney tumor14
leukemia116
liver tumor52
lymphoma13
non-neoplasia20
ovarian tumor13
pancreatic tumor28
primitive neuroectodermal tumor of the CNS23
prostate cancer48
retinoblastoma64
skin tumor31
soft tissue/muscle tissue tumor95
uterine tumor11
Developmental Stage
TissuesTPM*
adult35
blastocyst32
neonate64
fetus12
juvenile35
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue18.1
adrenal gland25.2
appendix15.2
bone marrow7.5
cerebral cortex9.5
colon18.7
duodenum11.9
esophagus10
gallbladder20.2
heart muscle15.5
kidney18.3
liver9.4
lung15.4
lymph node16.4
ovary11.3
pancreas5.4
placenta11
prostate16.2
salivary gland17.9
skin6.5
small intestine11.9
spleen10.6
stomach13.1
testis10.5
thyroid gland19.8
urinary bladder12.7
Tissues
TissuesExpression level
adrenal glandHigh
appendixMedium
bone marrowLow
breastMedium
bronchusMedium
cerebral cortexLow
colonHigh
duodenumHigh
endometrium 1Medium
endometrium 2Low
epididymisLow
esophagusLow
fallopian tubeMedium
gallbladderHigh
heart muscleLow
hippocampusLow
kidneyMedium
lateral ventricleLow
liverMedium
lungMedium
lymph nodeLow
nasopharynxMedium
oral mucosaLow
pancreasHigh
parathyroid glandLow
placentaLow
prostateHigh
rectumMedium
salivary glandHigh
seminal vesicleMedium
skeletal muscleMedium
skin 2Low
small intestineHigh
soft tissue 1Low
soft tissue 2Low
stomach 1High
stomach 2High
testisMedium
thyroid glandLow
tonsilLow
urinary bladderHigh
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*612491, gene) Apaf1-interacting protein; APIPOMIM


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