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> Protein (NX_Q96HA8)
Protein (NX_Q96HA8)
Protein
Gene SymbolWDYHV1 to neXtProt (NX_Q96HA8)
DescriptionProtein N-terminal glutamine amidohydrolase
Chromosome8
Location8q24.13 (124428965 ~ 124479470) to Ensembl
Sequene Features : Isoforms 2, Variants 33, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.cellular protein modification process .protein-N-terminal glutamine amidohydrolase activity .cytosol
.nucleus
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
2 33 0
2014-09-19protein level
2 29 0
2014-05-27protein level
1 29 0
2014-02-25protein level
1 29 0
2013-12-09protein level
1 25 0
2013-11-01protein level
1 25 0
2013-09-12protein level
1 25 0
2013-08-17protein level
1 25 0
2013-07-15protein level
1 19 0
2013-06-11protein level
1 19 0
2013-02-12protein level
1 9 0
2012-12-20protein level
1 9 0
2012-10-30protein level
1 8 0
2012-10-07protein level
1 8 0
2012-08-24protein level
1 8 0
2012-07-28protein level
1 8 0
2012-06-08protein level
1 8 0
2012-05-07protein level
1 6 0
2012-04-10protein level
1 6 0
2012-01-13protein level
1 7 0
2011-12-20protein level
1 7 0
2011-11-11protein level
1 7 0
2011-08-23protein level
1 7 0
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q96HA8-1
3 5 0 23664.148
NX_Q96HA8-2
0 5 0 16725.0604
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-741158,EBI-746373 GMDS  
  .'de novo' GDP-L-fucose biosynthetic process
.GDP-mannose metabolic process
.Notch signaling pathway
.NADP+ binding
.GDP-mannose 4,6-dehydratase activity
.extracellular exosome
.cytoplasm
2 EBI-741158,EBI-2683717 GAS7  
  .actin filament bundle assembly
.neuron projection morphogenesis
.actin filament polymerization
  + 3 more...
.sequence-specific DNA binding transcription factor activity .actin filament
.cytoplasm
.ruffle
3 EBI-741158,EBI-7875264 DAB1  
  .lateral motor column neuron migration
.Golgi localization
.negative regulation of axonogenesis
  + 15 more...
.N/A .perinuclear region of cytoplasm
.apical part of cell
.neuronal cell body
  + 5 more...
4 EBI-741158,EBI-714135 STX11  
  .membrane fusion
.vesicle docking
.natural killer cell degranulation
  + 4 more...
.SNAP receptor activity
.SNARE binding
.SNARE complex
.integral component of membrane
.endomembrane system
  + 3 more...
5 EBI-741158,EBI-2909270 KCNH1  
  .potassium ion transmembrane transport
.regulation of membrane potential
.regulation of cell proliferation
  + 3 more...
.delayed rectifier potassium channel activity
.phosphorelay sensor kinase activity
.early endosome membrane
.voltage-gated potassium channel complex
.integral component of plasma membrane
  + 4 more...
6 EBI-741158,EBI-536866 NUDT14  
  .N/A .ADP-ribose diphosphatase activity
.metal ion binding
.UDP-sugar diphosphatase activity
.extracellular exosome
.cytoplasm
7 EBI-741158,EBI-748210 HPRT1  
  .nucleobase-containing small molecule metabolic process
.protein homotetramerization
.dendrite morphogenesis
  + 23 more...
.guanine phosphoribosyltransferase activity
.protein homodimerization activity
.hypoxanthine phosphoribosyltransferase activity
  + 2 more...
.extracellular exosome
.cytosol
.cytoplasm
8 EBI-741158,EBI-6875961 CRYAA  
  .protein homooligomerization
.response to stimulus
.negative regulation of apoptotic process
  + 2 more...
.unfolded protein binding
.metal ion binding
.identical protein binding
.structural constituent of eye lens
.extracellular exosome
.cytoplasm
.nucleus
9 EBI-741158,EBI-750131 ASL  
  .small molecule metabolic process
.arginine biosynthetic process via ornithine
.cellular nitrogen compound metabolic process
  + 3 more...
.argininosuccinate lyase activity .extracellular exosome
.cytosol
.cytoplasm
10 EBI-741158,EBI-357469 PYGM  
  .small molecule metabolic process
.glucose metabolic process
.glycogen catabolic process
  + 2 more...
.pyridoxal phosphate binding
.glycogen phosphorylase activity
.nucleotide binding
.extracellular exosome
.cytosol
.cytoplasm
11 EBI-741158,EBI-4290895 PRPS2  
  .organ regeneration
.AMP biosynthetic process
.nucleobase-containing compound metabolic process
.5-phosphoribose 1-diphosphate biosynthetic process
.ADP binding
.protein homodimerization activity
.identical protein binding
  + 7 more...
.extracellular exosome
.ribose phosphate diphosphokinase complex
12 EBI-741158,EBI-719493 TRIM27  
  .negative regulation of viral release from host cell
.negative regulation of interleukin-2 secretion
.negative regulation of calcium ion import
  + 17 more...
.metal ion binding
.ligase activity
.zinc ion binding
  + 4 more...
.nuclear membrane
.PML body
.membrane
  + 6 more...
13 EBI-741158,EBI-702484 JUP  
  .regulation of ventricular cardiac muscle cell action potential
.positive regulation of canonical Wnt signaling pathway
.establishment of protein localization to plasma membrane
  + 20 more...
.cell adhesive protein binding involved in bundle of His cell-Purkinje myocyte communication
.cell adhesion molecule binding
.cadherin binding
  + 7 more...
.gamma-catenin-TCF7L2 complex
.extracellular exosome
.protein-DNA complex
  + 19 more...
14 EBI-741158,EBI-741141 NME1  
  .cellular response to fatty acid
.cellular response to glucose stimulus
.nucleobase-containing small molecule metabolic process
  + 22 more...
.poly(A) RNA binding
.ribosomal small subunit binding
.identical protein binding
  + 7 more...
.extracellular exosome
.perinuclear region of cytoplasm
.ruffle membrane
  + 7 more...
15 EBI-741158,EBI-5655000 CAPN3  
  .self proteolysis
.protein localization to membrane
.cellular response to salt stress
  + 25 more...
.ligase regulator activity
.protein complex scaffold
.titin binding
  + 8 more...
.protein complex
.T-tubule
.Z disc
  + 6 more...
16 EBI-741158,EBI-3958099 KRTAP5-9  
  .epidermis development .N/A .keratin filament
17 EBI-741158,EBI-9250559 CDA  
  .nucleobase-containing small molecule metabolic process
.protein homotetramerization
.negative regulation of nucleotide metabolic process
  + 8 more...
.protein homodimerization activity
.zinc ion binding
.cytidine deaminase activity
.nucleoside binding
.cytosol
.extracellular region
18 EBI-741158,EBI-749763 CTH  
  .negative regulation of apoptotic signaling pathway
.hydrogen sulfide biosynthetic process
.protein homotetramerization
  + 12 more...
.L-cysteine desulfhydrase activity
.homocysteine desulfhydrase activity
.L-cystine L-cysteine-lyase (deaminating)
  + 3 more...
.extracellular exosome
.cytosol
.cytoplasm
  + 2 more...
19 EBI-741158,EBI-1372759 ETV6  
  .hematopoietic stem cell proliferation
.cell differentiation
.transcription from RNA polymerase II promoter
  + 2 more...
.protein domain specific binding
.sequence-specific DNA binding transcription factor activity
.RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
  + 4 more...
.cytoplasm
.nucleolus
20 EBI-741158,EBI-10178634 MAGEA11  
  .N/A .N/A .cytoplasm
.nucleoplasm
.nucleus
21 EBI-741158,EBI-744831 RPIA  
  .small molecule metabolic process
.pentose-phosphate shunt, non-oxidative branch
.pentose-phosphate shunt
.carbohydrate metabolic process
.monosaccharide binding
.ribose-5-phosphate isomerase activity
.intracellular membrane-bounded organelle
.cytosol
22 EBI-741158,EBI-741925 DHPS  
  .protein homotetramerization
.deoxyhypusine biosynthetic process from spermidine
.cellular protein metabolic process
  + 6 more...
.deoxyhypusine synthase activity .cytosol
23 EBI-741158,EBI-10172150 KRTAP10-5  
  .N/A .identical protein binding .keratin filament
24 EBI-741158,EBI-10172290 KRTAP10-7  
  .N/A .identical protein binding .keratin filament
25 EBI-741158,EBI-353944 ACTB  
  .platelet aggregation
.membrane organization
.'de novo' posttranslational protein folding
  + 17 more...
.nitric-oxide synthase binding
.identical protein binding
.Tat protein binding
  + 3 more...
.blood microparticle
.MLL5-L complex
.extracellular exosome
  + 16 more...
26 EBI-741158,EBI-351292 ACTG1  
  .platelet aggregation
.membrane organization
.ephrin receptor signaling pathway
  + 11 more...
.identical protein binding
.ubiquitin protein ligase binding
.ATP binding
.structural constituent of cytoskeleton
.blood microparticle
.extracellular exosome
.filamentous actin
  + 7 more...
27 EBI-741158,EBI-1181367 CDR2  
  .N/A .N/A .cytoplasm
28 EBI-741158,EBI-618309 GOLGA2  
  .negative regulation of protein binding
.mitotic cell cycle
.syntaxin binding
.protein kinase binding
.Golgi cisterna membrane
.ER to Golgi transport vesicle
.cis-Golgi network
  + 4 more...
29 EBI-741158,EBI-2107455 VAC14  
  .small molecule metabolic process
.regulation of lipid kinase activity
.viral process
  + 3 more...
.receptor activity .PAS complex
.late endosome membrane
.early endosome membrane
  + 3 more...
30 EBI-741158,EBI-514538 BIRC2  
  .regulation of reactive oxygen species metabolic process
.regulation of cysteine-type endopeptidase activity
.inhibition of cysteine-type endopeptidase activity involved in apoptotic process
  + 40 more...
.protein N-terminus binding
.cysteine-type endopeptidase inhibitor activity involved in apoptotic process
.ligase activity
  + 3 more...
.membrane raft
.CD40 receptor complex
.cytoplasmic side of plasma membrane
  + 4 more...
31 EBI-741158,EBI-718504 BLMH  
  .response to drug
.response to toxic substance
.proteolysis
  + 2 more...
.cysteine-type peptidase activity
.cysteine-type endopeptidase activity
.carboxypeptidase activity
.aminopeptidase activity
.extracellular exosome
.cytosol
.cytoplasm
  + 2 more...
32 EBI-741158,EBI-491065 EIF2B1  
  .cellular response to stimulus
.cellular protein metabolic process
.positive regulation of GTPase activity
  + 9 more...
.enzyme regulator activity
.GDP binding
.GTP binding
.translation initiation factor activity
.membrane
.plasma membrane
.eukaryotic translation initiation factor 2B complex
  + 2 more...
33 EBI-741158,EBI-948001 KRT31  
  .epidermis development .structural constituent of cytoskeleton .extracellular exosome
.intermediate filament
.extracellular space
34 EBI-741158,EBI-358993 TRIP13  
  .regulation of nucleic acid-templated transcription
.oogenesis
.spermatid development
  + 8 more...
.identical protein binding
.ATP binding
.transcription cofactor activity
.nucleus
.male germ cell nucleus
35 EBI-741158,EBI-712609 TSC22D1  
  .negative regulation of apoptotic process
.positive regulation of apoptotic process
.positive regulation of cell proliferation
.transcription from RNA polymerase II promoter
.sequence-specific DNA binding transcription factor activity .cytoplasm
.nucleus
36 EBI-741158,EBI-2341787 LONRF1  
  .N/A .zinc ion binding
.ATP-dependent peptidase activity
.N/A
37 EBI-741158,EBI-3891843 AMOT  
  .positive regulation of stress fiber assembly
.positive regulation of cell size
.positive regulation of blood vessel endothelial cell migration
  + 16 more...
.angiostatin binding
.receptor activity
.endocytic vesicle
.lamellipodium
.integral component of membrane
  + 8 more...
38 EBI-741158,EBI-10179526 CCDC184  
  .N/A .N/A .cytoplasm
39 EBI-741158,EBI-740929 KLHL12  
  .negative regulation of canonical Wnt signaling pathway
.COPII vesicle coating
.Wnt signaling pathway
  + 2 more...
.N/A .Cul3-RING ubiquitin ligase complex
.ER to Golgi transport vesicle
.cytosol
.Golgi membrane
40 EBI-741158,EBI-742948 MTUS2  
  .N/A .protein homodimerization activity
.microtubule binding
.microtubule
.cytoplasm
.nucleus
41 EBI-741158,EBI-9027502 KCTD1  
  .protein homooligomerization
.negative regulation of transcription, DNA-templated
.transcription, DNA-templated
.transcription factor binding
.transcription corepressor activity
.nucleus
42 EBI-741158,EBI-747107 SIAH1  
  .positive regulation of intrinsic apoptotic signaling pathway
.neuron apoptotic process
.proteasome-mediated ubiquitin-dependent protein catabolic process
  + 11 more...
.ubiquitin protein ligase activity
.identical protein binding
.ligase activity
  + 3 more...
.beta-catenin destruction complex
.plasma membrane
.cytosol
  + 3 more...
43 EBI-741158,EBI-2341554 MARCH10  
  .protein ubiquitination .ligase activity
.zinc ion binding
.N/A
44 EBI-741158,EBI-302345 PNMA1  
  .positive regulation of apoptotic process
.inflammatory response to antigenic stimulus
.N/A .focal adhesion
.cytoplasm
.nucleolus
45 EBI-741158,EBI-9675724 TMEM239  
  .N/A .N/A .integral component of membrane
46 EBI-741158,EBI-2949647 EDARADD  
  .trachea gland development
.odontogenesis of dentin-containing tooth
.cell differentiation
  + 2 more...
.N/A .cytoplasm
47 EBI-741158,EBI-5333483 RAD54L  
  .chromosome organization
.response to drug
.response to ionizing radiation
  + 5 more...
.annealing helicase activity
.ATP binding
.helicase activity
.DNA binding
.nucleoplasm
.nucleus
48 EBI-741158,EBI-740322 RBPMS  
  .positive regulation of SMAD protein import into nucleus
.positive regulation of pathway-restricted SMAD protein phosphorylation
.RNA processing
  + 2 more...
.poly(A) RNA binding
.poly(A) binding
.transcription coactivator activity
.nucleotide binding
.cytoplasm
.nucleoplasm
49 EBI-741158,EBI-742740 ZBTB8A  
  .regulation of transcription, DNA-templated
.transcription, DNA-templated
.metal ion binding
.DNA binding
.nucleus
50 EBI-741158,EBI-724333 PPCDC  
  .small molecule metabolic process
.pantothenate metabolic process
.coenzyme A biosynthetic process
  + 3 more...
.phosphopantothenoylcysteine decarboxylase activity .cytosol
51 EBI-741158,EBI-359248 APIP  
  .regulation of ERK1 and ERK2 cascade
.small molecule metabolic process
.negative regulation of apoptotic process
  + 6 more...
.methylthioribulose 1-phosphate dehydratase activity
.identical protein binding
.zinc ion binding
.cytoplasm
52 EBI-741158,EBI-10171633 PNMA5  
  .positive regulation of apoptotic process .identical protein binding .N/A
53 EBI-741158,EBI-78738 PRMT1  
  .negative regulation of megakaryocyte differentiation
.histone H4-R3 methylation
.neuron projection development
  + 7 more...
.poly(A) RNA binding
.histone methyltransferase activity (H4-R3 specific)
.identical protein binding
  + 5 more...
.cytosol
.cytoplasm
.nucleoplasm
.nucleus
54 EBI-741158,EBI-742664 HSD17B14  
  .steroid catabolic process .testosterone 17-beta-dehydrogenase (NADP+) activity
.estradiol 17-beta-dehydrogenase activity
.cytosol
55 EBI-741158,EBI-741037 LZTS2  
  .negative regulation of protein localization to nucleus
.negative regulation of canonical Wnt signaling pathway
.spindle midzone assembly
  + 7 more...
.N/A .midbody
.microtubule
.centrosome
.cytoplasm
56 EBI-741158,EBI-2874661 C1orf50  
  .N/A .N/A .N/A
57 EBI-741158,EBI-10287915 NPL  
  .cellular protein metabolic process
.post-translational protein modification
.N-acetylneuraminate catabolic process
  + 2 more...
.N-acetylneuraminate lyase activity .cytosol
58 EBI-741158,EBI-9089622 ZNF341  
  .regulation of transcription, DNA-templated
.transcription, DNA-templated
.metal ion binding
.DNA binding
.nucleus
59 EBI-741158,EBI-10185730 KRTAP9-4  
  .N/A .N/A .keratin filament
60 EBI-741158,EBI-1044640 KRTAP9-2  
  .N/A .N/A .keratin filament
61 EBI-741158,EBI-10172511 KRTAP4-2  
  .N/A .N/A .keratin filament
62 EBI-741158,EBI-2130429 TRIM54  
  .cell differentiation
.multicellular organismal development
.signal transduction
  + 2 more...
.zinc ion binding
.signal transducer activity
.Z disc
.microtubule associated complex
.microtubule
63 EBI-741158,EBI-74615 TOLLIP  
  .leukocyte activation
.innate immune response
.protein localization to endosome
  + 8 more...
.Toll-like receptor binding
.kinase binding
.signal transducer activity
.extracellular exosome
.perinuclear region of cytoplasm
.interleukin-1 receptor complex
  + 4 more...
64 EBI-741158,EBI-2824799 LZTFL1  
  .negative regulation of protein localization to ciliary membrane
.negative regulation of protein localization to cilium
.establishment of protein localization to organelle
.organelle organization
.identical protein binding
.protein complex binding
.BBSome
.cytosol
65 EBI-741158,EBI-741515 THAP1  
  .regulation of mitotic cell cycle
.cell cycle
.regulation of transcription, DNA-templated
  + 2 more...
.sequence-specific DNA binding
.identical protein binding
.zinc ion binding
.PML body
.nucleus
66 EBI-741158,EBI-727037 SEPT3  
  .cell division
.cell cycle
.GTP binding .synapse
.cell junction
.cytoskeleton
.cytoplasm
67 EBI-741158,EBI-712367 RABAC1  
  .N/A .identical protein binding .cell junction
.integral component of membrane
.membrane
  + 3 more...
68 EBI-741158,EBI-10187270 AMOTL2  
  .hippo signaling
.Wnt signaling pathway
.N/A .recycling endosome
.cytoplasmic vesicle
.apical plasma membrane
  + 2 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adrenal gland91
blood24
bone55
bone marrow41
brain19
ear124
embryonic tissue28
eye28
intestine12
kidney18
larynx127
liver19
lung14
lymph node44
mammary gland6
ovary19
pancreas18
pharynx24
placenta17
prostate47
skin28
spleen37
thymus12
uterus51
vascular19
Health State
TissuesTPM*
normal21
adrenal tumor79
breast (mammary gland) tumor10
chondrosarcoma36
colorectal tumor8
germ cell tumor45
glioma102
head and neck tumor22
kidney tumor14
leukemia21
liver tumor10
lung tumor29
ovarian tumor13
pancreatic tumor38
primitive neuroectodermal tumor of the CNS15
prostate cancer9
retinoblastoma43
skin tumor15
soft tissue/muscle tissue tumor63
uterine tumor22
Developmental Stage
TissuesTPM*
adult21
blastocyst48
fetus32
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue6.8
adrenal gland12
appendix7.5
bone marrow4.3
cerebral cortex9.8
colon7.9
duodenum5.4
esophagus7.3
gallbladder7.9
heart muscle17.2
kidney8
liver4.8
lung6.7
lymph node8.5
ovary15.8
pancreas4.6
placenta6
prostate9.9
salivary gland5.8
skin6.5
small intestine4.4
spleen6.5
stomach5.3
testis14
thyroid gland13.9
urinary bladder6.9
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected


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