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> Protein (NX_Q96HC4)
Protein (NX_Q96HC4)
Protein
Gene SymbolPDLIM5 to neXtProt (NX_Q96HC4)
DescriptionPDZ and LIM domain protein 5
Chromosome4
Location4q22.3 (95373037 ~ 95589377) to Ensembl
Sequene Features : Isoforms 7, Variants 100, PTMs 16 to neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.regulation of dendritic spine morphogenesis
.regulation of synapse assembly
.actinin binding
.zinc ion binding
.protein kinase C binding
.actin binding
.postsynaptic membrane
.neuron projection
.cell junction
  + 5 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
7 100 16
2014-09-19protein level
7 82 16
2014-05-27protein level
7 82 16
2014-02-25protein level
5 77 13
2013-12-09protein level
5 65 13
2013-11-01protein level
5 63 12
2013-09-12protein level
5 63 13
2013-08-17protein level
5 63 13
2013-07-15protein level
5 45 13
2013-06-11protein level
5 45 13
2013-02-12protein level
5 29 26
2012-12-20protein level
4 27 26
2012-10-30protein level
4 30 26
2012-10-07protein level
4 30 14
2012-08-24protein level
4 29 14
2012-07-28protein level
4 29 14
2012-06-08protein level
4 30 14
2012-05-07protein level
4 22 14
2012-04-10protein level
4 22 14
2012-01-13protein level
4 21 14
2011-12-20protein level
4 21 14
2011-11-11protein level
4 21 12
2011-08-23protein level
4 21 12
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q96HC4-1
5 23 0 63904.3095
NX_Q96HC4-2
0 11 0 25914.3053
NX_Q96HC4-3
1 11 0 23808.408
NX_Q96HC4-4
0 23 0 53043.7406
NX_Q96HC4-5
5 1 1 15106.6857
NX_Q96HC4-6
8 22 0 67685.3693
NX_Q96HC4-7
0 23 0 52611.6563
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-751267,EBI-945751 COIL  
  .N/A .identical protein binding
.protein C-terminus binding
.membrane
.Cajal body
.cytoplasm
  + 3 more...
2 EBI-751267,EBI-10172290 KRTAP10-7  
  .N/A .identical protein binding .keratin filament
3 EBI-751267,EBI-444225 ZYX  
  .regulation of inflammatory response
.stress fiber assembly
.viral process
  + 6 more...
.poly(A) RNA binding
.zinc ion binding
.focal adhesion
.cell-cell adherens junction
.integral component of plasma membrane
  + 4 more...
4 EBI-751267,EBI-10171697 KRT40  
  .N/A .structural molecule activity .intermediate filament
5 EBI-751267,EBI-10171416 CCDC136  
  .N/A .N/A .integral component of membrane
.mitochondrion
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue155
adrenal gland91
ascites25
bladder100
blood32
bone209
bone marrow164
brain59
cervix41
connective tissue107
ear124
embryonic tissue84
esophagus99
eye95
heart670
intestine60
kidney142
larynx85
liver107
lung56
lymph22
lymph node22
mammary gland158
mouth120
muscle958
nerve128
ovary88
pancreas70
pharynx24
pituitary gland60
placenta162
prostate147
skin94
spleen56
stomach114
testis29
thymus25
thyroid64
uterus4
Health State
TissuesTPM*
normal151
breast (mammary gland) tumor75
cervical tumor57
chondrosarcoma96
colorectal tumor53
esophageal tumor115
gastrointestinal tumor92
germ cell tumor11
glioma46
head and neck tumor67
kidney tumor101
leukemia31
liver tumor62
lung tumor19
lymphoma13
non-neoplasia82
ovarian tumor105
pancreatic tumor66
primitive neuroectodermal tumor of the CNS47
prostate cancer154
retinoblastoma64
skin tumor87
soft tissue/muscle tissue tumor63
uterine tumor55
Developmental Stage
TissuesTPM*
adult137
embryoid body85
blastocyst65
neonate193
fetus159
juvenile35
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue43.1
adrenal gland27.6
appendix33.6
bone marrow34.2
cerebral cortex31.3
colon40.3
duodenum34.6
esophagus223.9
gallbladder96.6
heart muscle851
kidney33.4
liver72.2
lung31
lymph node25.4
ovary35.9
pancreas22.3
placenta80.4
prostate99.7
salivary gland36.2
skin18.8
small intestine36.2
spleen23.2
stomach35.4
testis21.5
thyroid gland54.5
urinary bladder74.1
Tissues
TissuesExpression level
adrenal glandMedium
appendixMedium
bone marrowLow
breastMedium
bronchusMedium
cerebellumLow
cerebral cortexMedium
cervix, uterineLow
colonMedium
duodenumMedium
endometrium 1Medium
endometrium 2Medium
epididymisLow
esophagusMedium
fallopian tubeMedium
gallbladderMedium
heart muscleHigh
hippocampusLow
kidneyMedium
lateral ventricleLow
liverLow
lungMedium
lymph nodeLow
nasopharynxMedium
oral mucosaMedium
ovaryLow
pancreasMedium
parathyroid glandLow
placentaMedium
prostateLow
rectumMedium
salivary glandMedium
seminal vesicleLow
skeletal muscleHigh
skin 1Medium
skin 2Low
small intestineMedium
smooth muscleMedium
soft tissue 1Low
spleenLow
stomach 1Medium
stomach 2Medium
testisLow
thyroid glandLow
tonsilLow
urinary bladderMedium
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*605904, gene) Pdz and lim domain protein 5; PDLIM5OMIM


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