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> Protein (NX_Q96HD9)
Protein (NX_Q96HD9)
Protein
Gene SymbolACY3 to neXtProt (NX_Q96HD9)
DescriptionN-acyl-aromatic-L-amino acid amidohydrolase (carboxylate-forming)
Chromosome11
Location11q13.2 (67410026 ~ 67418130) to Ensembl
Sequene Features : Isoforms 1, Variants 50, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.small molecule metabolic process
.viral process
.xenobiotic metabolic process
.metal ion binding
.hydrolase activity, acting on ester bonds
.aminoacylase activity
.extracellular exosome
.apical plasma membrane
.cytosol
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
1 50 0
2014-09-19protein level
1 37 0
2014-05-27protein level
1 37 0
2014-02-25protein level
1 36 0
2013-12-09protein level
1 25 0
2013-11-01protein level
1 23 0
2013-09-12protein level
1 23 0
2013-08-17protein level
1 23 0
2013-07-15protein level
1 16 0
2013-06-11protein level
1 16 0
2013-02-12protein level
1 8 0
2012-12-20protein level
1 8 0
2012-10-30protein level
1 10 0
2012-10-07protein level
1 10 0
2012-08-24protein level
1 10 0
2012-07-28protein level
1 10 0
2012-06-08protein level
1 10 0
2012-05-07protein level
1 10 0
2012-04-10protein level
1 10 0
2012-01-13protein level
1 9 0
2011-12-20protein level
1 9 0
2011-11-11protein level
1 9 0
2011-08-23protein level
1 9 0
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q96HD9-1
17 0 0 35218.4261
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-3916242,EBI-10182608 PMM2  
  .cellular protein metabolic process
.post-translational protein modification
.mannose biosynthetic process
  + 4 more...
.phosphomannomutase activity .extracellular exosome
.neuronal cell body
.cytosol
2 EBI-3916242,EBI-348555 PIAS2  
  .negative regulation of androgen receptor signaling pathway
.positive regulation of transcription from RNA polymerase II promoter
.positive regulation of transcription, DNA-templated
  + 7 more...
.SUMO ligase activity
.androgen receptor binding
.ligase activity
  + 4 more...
.nuclear speck
.PML body
.nucleoplasm
.nucleus
3 EBI-3916242,EBI-750475 ASPA  
  .positive regulation of oligodendrocyte differentiation
.central nervous system myelination
.aspartate catabolic process
.metal ion binding
.aspartoacylase activity
.hydrolase activity, acting on ester bonds
.aminoacylase activity
.extracellular exosome
.cytoplasm
.nucleus
4 EBI-3916242,EBI-945833 NOTCH2NL  
  .cell differentiation
.multicellular organismal development
.Notch signaling pathway
.calcium ion binding .cytoplasm
.extracellular region
5 EBI-3916242,EBI-739832 LNX1  
  .protein homooligomerization
.protein ubiquitination involved in ubiquitin-dependent protein catabolic process
.ligase activity
.zinc ion binding
.ubiquitin-protein transferase activity
.cytoplasm
6 EBI-3916242,EBI-10308705 AAMDC  
  .positive regulation of transcription from RNA polymerase II promoter
.positive regulation of fat cell differentiation
.negative regulation of apoptotic process
.N/A .cytoplasm
7 EBI-3916242,EBI-742388 PLEKHF2  
  .protein transport .metal ion binding .early endosome membrane
.transport vesicle
.endoplasmic reticulum
8 EBI-3916242,EBI-739467 GORASP2  
  .organelle organization
.mitotic cell cycle
.N/A .membrane
.Golgi apparatus
.Golgi membrane
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
ascites25
blood8
brain2
intestine12
kidney42
liver9
lymph22
mammary gland6
prostate5
Health State
TissuesTPM*
normal6
colorectal tumor8
gastrointestinal tumor8
leukemia10
liver tumor10
lymphoma13
Developmental Stage
TissuesTPM*
adult3
fetus7
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
appendix3.5
cerebral cortex3.1
colon5.8
duodenum54.4
gallbladder1.8
kidney54
liver11.3
lymph node5.2
pancreas9.5
salivary gland1.6
small intestine48.5
spleen1.4
stomach8.7
Tissues
TissuesExpression level
adrenal glandLow
appendixLow
bronchusLow
colonMedium
duodenumHigh
epididymisLow
gallbladderMedium
heart muscleLow
kidneyHigh
lateral ventricleLow
liverMedium
lungMedium
nasopharynxLow
rectumHigh
skeletal muscleMedium
small intestineMedium
soft tissue 1Medium
soft tissue 2Medium
stomach 1Medium
stomach 2Medium
testisLow
urinary bladderLow
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*614413, gene) Aminoacylase 3; ACY3OMIM


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