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> Protein (NX_Q96HE7)
Protein (NX_Q96HE7)
Protein
Gene SymbolERO1L to neXtProt (NX_Q96HE7)
DescriptionERO1-like protein alpha
Chromosome14
Location14q22.1 (53106634 ~ 53162618) to Ensembl
Sequene Features : Isoforms 1, Variants 43, PTMs 11 to neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
.release of sequestered calcium ion into cytosol
.chaperone mediated protein folding requiring cofactor
  + 12 more...
.oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor
.oxidoreductase activity
.protein disulfide oxidoreductase activity
.protein disulfide isomerase activity
.intracellular membrane-bounded organelle
.membrane
.endoplasmic reticulum membrane
  + 2 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
1 43 11
2014-09-19protein level
1 31 11
2014-05-27protein level
1 31 11
2014-02-25protein level
1 31 11
2013-12-09protein level
1 25 11
2013-11-01protein level
1 24 11
2013-09-12protein level
1 24 11
2013-08-17protein level
1 24 11
2013-07-15protein level
1 16 11
2013-06-11protein level
1 16 11
2013-02-12protein level
1 3 11
2012-12-20protein level
1 4 11
2012-10-30protein level
1 6 11
2012-10-07protein level
1 6 11
2012-08-24protein level
1 5 11
2012-07-28protein level
1 5 11
2012-06-08protein level
1 21 11
2012-05-07protein level
1 21 11
2012-04-10protein level
1 21 11
2012-01-13protein level
1 17 11
2011-12-20protein level
1 17 11
2011-11-11protein level
1 17 10
2011-08-23protein level
1 17 10
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q96HE7-1
20 0 2 54357.9007
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-2564539,EBI-395883 P4HB  
  .regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
.cellular response to hypoxia
.cell redox homeostasis
  + 8 more...
.poly(A) RNA binding
.procollagen-proline 4-dioxygenase activity
.endopeptidase activity
.protein disulfide isomerase activity
.extracellular exosome
.melanosome
.procollagen-proline 4-dioxygenase complex
  + 6 more...
2 EBI-2564539,EBI-979862 PDIA3  
  .positive regulation of extrinsic apoptotic signaling pathway
.oxidation-reduction process
.cell redox homeostasis
  + 13 more...
.poly(A) RNA binding
.disulfide oxidoreductase activity
.phospholipase C activity
  + 2 more...
.extracellular exosome
.melanosome
.cell surface
  + 5 more...
3 EBI-2564539,EBI-743771 APPBP2  
  .intracellular transport
.metabolic process
.intracellular protein transport
.microtubule motor activity .cytoplasmic vesicle membrane
.microtubule associated complex
.microtubule
  + 2 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adrenal gland121
bladder100
blood24
bone111
bone marrow41
brain30
cervix123
connective tissue93
embryonic tissue37
esophagus198
eye33
heart22
intestine38
kidney23
larynx85
liver24
lung53
lymph node77
mammary gland26
mouth60
muscle37
nerve128
ovary19
pancreas28
parathyroid48
pharynx24
pituitary gland60
placenta24
prostate31
skin37
stomach10
testis4
thymus25
trachea96
uterus25
vascular58
Health State
TissuesTPM*
normal34
adrenal tumor237
breast (mammary gland) tumor10
cervical tumor173
chondrosarcoma96
colorectal tumor26
esophageal tumor173
gastrointestinal tumor42
germ cell tumor11
glioma9
head and neck tumor52
kidney tumor29
leukemia31
liver tumor10
lung tumor58
pancreatic tumor19
primitive neuroectodermal tumor of the CNS86
prostate cancer38
retinoblastoma64
skin tumor31
soft tissue/muscle tissue tumor103
uterine tumor33
Developmental Stage
TissuesTPM*
adult36
embryoid body71
blastocyst32
neonate64
fetus41
juvenile53
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue12.2
adrenal gland10.7
appendix30.2
bone marrow46.6
cerebral cortex14.2
colon19.7
duodenum20
esophagus243.2
gallbladder23.2
heart muscle7.4
kidney12.3
liver17.4
lung13.3
lymph node15.5
ovary6.6
pancreas9.1
placenta36.9
prostate9.6
salivary gland15.2
skin11.5
small intestine19.3
spleen14.3
stomach35.8
testis8.8
thyroid gland15.2
urinary bladder34.7
Tissues
TissuesExpression level
adrenal glandMedium
appendixLow
bone marrowLow
breastLow
bronchusMedium
cerebellumLow
cerebral cortexLow
cervix, uterineLow
colonLow
duodenumMedium
endometrium 1Medium
endometrium 2Medium
epididymisLow
esophagusHigh
fallopian tubeMedium
gallbladderMedium
hippocampusMedium
kidneyMedium
lateral ventricleMedium
liverMedium
lungMedium
lymph nodeMedium
nasopharynxMedium
oral mucosaHigh
pancreasLow
parathyroid glandLow
placentaMedium
prostateLow
rectumLow
salivary glandLow
seminal vesicleMedium
skin 1Medium
skin 2Medium
small intestineMedium
soft tissue 1Low
soft tissue 2Low
spleenLow
stomach 1Medium
stomach 2Medium
testisMedium
thyroid glandLow
tonsilHigh
urinary bladderMedium
vaginaMedium
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected


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