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> Protein (NX_Q96HT8)
Protein (NX_Q96HT8)
Protein
Gene SymbolMRFAP1L1 to neXtProt (NX_Q96HT8)
DescriptionMORF4 family-associated protein 1-like 1
Chromosome4
Location4p16.1 (6709428 ~ 6711607) to Ensembl
Sequene Features : Isoforms 1, Variants 14, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.N/A .identical protein binding .N/A
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
1 14 1
2014-09-19protein level
1 11 1
2014-05-27protein level
1 11 2
2014-02-25protein level
1 11 2
2013-12-09protein level
1 7 2
2013-11-01protein level
1 7 2
2013-09-12protein level
1 7 2
2013-08-17protein level
1 7 2
2013-07-15protein level
1 4 0
2013-06-11protein level
1 4 0
2013-02-12transcript level
1 4 0
2012-12-20transcript level
1 4 0
2012-10-30transcript level
1 4 0
2012-10-07transcript level
1 4 0
2012-08-24transcript level
1 4 0
2012-07-28transcript level
1 4 0
2012-06-08transcript level
1 5 0
2012-05-07transcript level
1 5 0
2012-04-10transcript level
1 5 0
2012-01-13transcript level
1 5 0
2011-12-20transcript level
1 5 0
2011-11-11transcript level
1 5 0
2011-08-23transcript level
1 5 0
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q96HT8-1
4 0 1 14798.2696
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-748896,EBI-346930 PIK3R2  
  .regulation of small GTPase mediated signal transduction
.leukocyte migration
.T cell receptor signaling pathway
  + 25 more...
.protein heterodimerization activity
.1-phosphatidylinositol-3-kinase regulator activity
.receptor tyrosine kinase binding
.protein phosphatase binding
.phosphatidylinositol 3-kinase complex
.cytosol
.nucleus
2 EBI-748896,EBI-727004 SDCBP  
  .positive regulation of extracellular exosome assembly
.positive regulation of exosomal secretion
.ephrin receptor signaling pathway
  + 9 more...
.protein N-terminus binding
.protein heterodimerization activity
.syndecan binding
  + 4 more...
.blood microparticle
.extracellular exosome
.melanosome
  + 12 more...
3 EBI-748896,EBI-1052532 CDK2AP1  
  .cell cycle
.DNA-dependent DNA replication
.positive regulation of protein phosphorylation
.DNA polymerase binding .perinuclear region of cytoplasm
.nucleus
4 EBI-748896,EBI-740220 HGS  
  .positive regulation of exosomal secretion
.protein localization to membrane
.membrane organization
  + 13 more...
.metal ion binding
.protein domain specific binding
.extracellular exosome
.intracellular membrane-bounded organelle
.multivesicular body membrane
  + 6 more...
5 EBI-748896,EBI-533224 TCF4  
  .protein-DNA complex assembly
.positive regulation of transcription from RNA polymerase II promoter
.positive regulation of transcription, DNA-templated
  + 3 more...
.E-box binding
.protein heterodimerization activity
.bHLH transcription factor binding
  + 9 more...
.transcription factor complex
.nucleus
6 EBI-748896,EBI-359352 PSMA1  
  .positive regulation of canonical Wnt signaling pathway
.negative regulation of canonical Wnt signaling pathway
.regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
  + 23 more...
.threonine-type endopeptidase activity
.endopeptidase activity
.RNA binding
.extracellular exosome
.proteasome core complex, alpha-subunit complex
.polysome
  + 7 more...
7 EBI-748896,EBI-739696 LMO2  
  .cellular response to thyroid hormone stimulus
.positive regulation of transcription from RNA polymerase II promoter
.negative regulation of erythrocyte differentiation
  + 3 more...
.E-box binding
.cofactor binding
.bHLH transcription factor binding
  + 7 more...
.transcription factor complex
.nucleus
8 EBI-748896,EBI-466029 HTT  
  .negative regulation of extrinsic apoptotic signaling pathway
.iron ion homeostasis
.L-glutamate import
  + 38 more...
.diazepam binding
.beta-tubulin binding
.dynein intermediate chain binding
  + 6 more...
.protein complex
.cytoplasmic vesicle membrane
.dendrite
  + 11 more...
9 EBI-748896,EBI-358049 BYSL  
  .cell proliferation
.female pregnancy
.cell adhesion
  + 2 more...
.poly(A) RNA binding .apical part of cell
.intracellular membrane-bounded organelle
.membrane
  + 3 more...
10 EBI-748896,EBI-399257 MORF4L2  
  .positive regulation of striated muscle cell differentiation
.positive regulation of transcription from RNA polymerase II promoter
.regulation of growth
  + 4 more...
.N/A .nucleolus
.nucleoplasm
11 EBI-748896,EBI-10239155 CSPP1  
  .positive regulation of cell division
.positive regulation of cytokinesis
.N/A .microtubule
.spindle
.centrosome
  + 3 more...
12 EBI-748896,EBI-298027 SMU1  
  .N/A .N/A .cytoplasm
.nucleus
13 EBI-748896,EBI-2837036 C3orf62  
  .N/A .N/A .N/A
14 EBI-748896,EBI-1104535 SFR1  
  .double-strand break repair via homologous recombination .N/A .Swi5-Sfr1 complex
.nucleus
15 EBI-748896,EBI-2800657 TMEM126B  
  .N/A .N/A .mitochondrial membrane
.integral component of membrane
16 EBI-748896,EBI-8638439 CCDC36  
  .positive regulation of defense response to virus by host .N/A .N/A
17 EBI-748896,EBI-6872807 SYCE1  
  .cell division
.synaptonemal complex assembly
.N/A .central element
18 EBI-748896,EBI-10288724 RDM1  
  .DNA recombination
.DNA repair
.RNA binding
.DNA binding
.nucleotide binding
.PML body
.Cajal body
.cytoplasm
.nucleolus
19 EBI-748896,EBI-739832 LNX1  
  .protein homooligomerization
.protein ubiquitination involved in ubiquitin-dependent protein catabolic process
.ligase activity
.zinc ion binding
.ubiquitin-protein transferase activity
.cytoplasm
20 EBI-748896,EBI-10196469 CAGE1  
  .N/A .N/A .N/A
21 EBI-748896,EBI-10232538 PIH1D2  
  .N/A .Ral GTPase binding .N/A
22 EBI-748896,EBI-455078 SMARCE1  
  .negative regulation of transcription, DNA-templated
.ATP-dependent chromatin remodeling
.metabolic process
  + 4 more...
.protein N-terminus binding
.ligand-dependent nuclear receptor binding
.N-acetyltransferase activity
  + 4 more...
.nBAF complex
.npBAF complex
.protein complex
  + 6 more...
23 EBI-748896,EBI-3893101 PRKCDBP  
  .negative regulation of fermentation
.positive regulation of ERK1 and ERK2 cascade
.negative regulation of protein kinase B signaling
  + 2 more...
.protein kinase C binding .protein complex
.caveola
.cytoplasm
24 EBI-748896,EBI-744267 RADIL  
  .substrate adhesion-dependent cell spreading
.multicellular organismal development
.signal transduction
.N/A .microtubule
25 EBI-748896,EBI-2932492 TXN2  
  .oxidation-reduction process
.response to axon injury
.cell redox homeostasis
  + 12 more...
.peptide-methionine (R)-S-oxide reductase activity
.oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor
.protein disulfide oxidoreductase activity
.peptide-methionine (S)-S-oxide reductase activity
.neuronal cell body
.dendrite
.mitochondrial matrix
  + 2 more...
26 EBI-748896,EBI-6871750 CENPK  
  .positive regulation of transcription from RNA polymerase II promoter
.CENP-A containing nucleosome assembly
.small GTPase mediated signal transduction
  + 2 more...
.N/A .cytosol
.nucleoplasm
.condensed chromosome kinetochore
27 EBI-748896,EBI-744115 CEP44  
  .N/A .N/A .midbody
.centrosome
.cytoplasm
.spindle pole
28 EBI-748896,EBI-745871 UBTD1  
  .N/A .N/A .N/A
29 EBI-748896,EBI-743598 ABI2  
  .positive regulation of Arp2/3 complex-mediated actin nucleation
.peptidyl-tyrosine phosphorylation
.Rac protein signal transduction
  + 5 more...
.proline-rich region binding
.protein complex binding
.ubiquitin protein ligase binding
  + 4 more...
.SCAR complex
.filopodium
.lamellipodium
  + 3 more...
30 EBI-748896,EBI-742038 ABI3  
  .regulation of cell migration
.movement of cell or subcellular component
.N/A .lamellipodium
.membrane
.cytoplasm
.intracellular
31 EBI-748896,EBI-399246 MORF4L1  
  .histone H2A acetylation
.histone H4 acetylation
.regulation of growth
  + 6 more...
.protein N-terminus binding
.chromatin binding
.NuA4 histone acetyltransferase complex
.Sin3 complex
.nucleoplasm
32 EBI-748896,EBI-995714 MRFAP1  
  .N/A .N/A .perinuclear region of cytoplasm
.nucleoplasm
.nucleus
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adrenal gland91
ascites25
bladder33
blood40
bone69
bone marrow82
brain119
cervix41
connective tissue20
embryonic tissue126
esophagus49
eye90
heart212
intestine73
kidney71
larynx42
liver53
lung74
lymph22
lymph node77
mammary gland72
mouth120
muscle103
nerve64
ovary19
pancreas32
parathyroid48
pharynx49
pituitary gland121
placenta155
prostate110
salivary gland98
skin66
spleen224
stomach20
testis41
thymus200
thyroid107
tonsil58
trachea19
umbilical cord145
uterus90
vascular19
Health State
TissuesTPM*
normal103
bladder carcinoma113
breast (mammary gland) tumor53
cervical tumor28
chondrosarcoma60
colorectal tumor62
esophageal tumor57
gastrointestinal tumor8
germ cell tumor98
glioma27
head and neck tumor67
kidney tumor116
leukemia95
liver tumor31
lung tumor29
lymphoma41
non-neoplasia134
ovarian tumor13
pancreatic tumor28
primitive neuroectodermal tumor of the CNS78
prostate cancer105
retinoblastoma86
skin tumor47
soft tissue/muscle tissue tumor55
uterine tumor44
Developmental Stage
TissuesTPM*
adult80
embryoid body100
blastocyst81
neonate96
fetus120
infant212
juvenile35
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue29.5
adrenal gland52.9
appendix40.9
bone marrow15.1
cerebral cortex61.4
colon34.6
duodenum29.6
esophagus39.5
gallbladder42.3
heart muscle47.8
kidney46.4
liver30.3
lung40.6
lymph node62.8
ovary61.5
pancreas16.6
placenta47.7
prostate53.9
salivary gland39.9
skin34.3
small intestine29.5
spleen46.8
stomach39.6
testis29.3
thyroid gland48.5
urinary bladder55.5
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)


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