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> Protein (NX_Q96IV0)
Protein (NX_Q96IV0)
Protein
Gene SymbolNGLY1 to neXtProt (NX_Q96IV0)
DescriptionPeptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase
Chromosome3
Location3p24.2 (25760435 ~ 25831530) to Ensembl
Sequene Features : Isoforms 5, Variants 82, PTMs 12 to neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.glycoprotein catabolic process .metal ion binding
.peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine amidase activity
.cytoplasm
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
5 82 12
2014-09-19protein level
5 68 12
2014-05-27protein level
5 67 12
2014-02-25protein level
5 67 12
2013-12-09protein level
5 52 12
2013-11-01protein level
5 50 12
2013-09-12protein level
5 50 12
2013-08-17protein level
5 50 12
2013-07-15protein level
5 28 1
2013-06-11protein level
5 28 1
2013-02-12protein level
5 12 3
2012-12-20protein level
5 12 3
2012-10-30protein level
5 16 3
2012-10-07protein level
5 16 1
2012-08-24protein level
5 13 1
2012-07-28protein level
5 13 1
2012-06-08protein level
5 13 1
2012-05-07protein level
5 13 1
2012-04-10protein level
4 13 1
2012-01-13protein level
4 11 1
2011-12-20protein level
4 11 1
2011-11-11protein level
4 11 1
2011-08-23protein level
4 11 1
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q96IV0-1
0 32 0 74343.1988
NX_Q96IV0-2
2 28 0 72239.7056
NX_Q96IV0-3
1 25 0 63787.2656
NX_Q96IV0-4
0 7 0 14893.2183
NX_Q96IV0-5
0 30 0 70167.1168
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-6165879,EBI-1396921 TRAFD1  
  .negative regulation of innate immune response
.response to cytokine
.metal ion binding .N/A
2 EBI-6165879,EBI-746453 RAD23A  
  .positive regulation of viral genome replication
.proteasome-mediated ubiquitin-dependent protein catabolic process
.regulation of proteasomal ubiquitin-dependent protein catabolic process
  + 2 more...
.ubiquitin-specific protease binding
.polyubiquitin binding
.single-stranded DNA binding
.damaged DNA binding
.cytoplasm
.nucleoplasm
.proteasome complex
3 EBI-6165879,EBI-954531 RAD23B  
  .proteasome-mediated ubiquitin-dependent protein catabolic process
.regulation of proteasomal ubiquitin-dependent protein catabolic process
.spermatogenesis
  + 4 more...
.polyubiquitin binding
.single-stranded DNA binding
.damaged DNA binding
.XPC complex
.cytoplasm
.nucleoplasm
  + 2 more...
4 EBI-6165879,EBI-1993619 UBXN2B  
  .membrane fusion
.regulation of catalytic activity
.proteasome-mediated ubiquitin-dependent protein catabolic process
  + 3 more...
.ubiquitin binding
.protein phosphatase type 1 regulator activity
.cytosol
.Golgi apparatus
.endoplasmic reticulum
.nucleus
5 EBI-6165879,EBI-8293751 GUCD1  
  .N/A .N/A .N/A
6 EBI-6165879,EBI-2130429 TRIM54  
  .cell differentiation
.multicellular organismal development
.signal transduction
  + 2 more...
.zinc ion binding
.signal transducer activity
.Z disc
.microtubule associated complex
.microtubule
7 EBI-6165879,EBI-741480 UBQLN1  
  .regulation of autophagic vacuole assembly
.positive regulation of ER-associated ubiquitin-dependent protein catabolic process
.regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
  + 8 more...
.identical protein binding
.polyubiquitin binding
.kinase binding
.perinuclear region of cytoplasm
.protein complex
.aggresome
  + 6 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
ascites25
bladder66
blood139
bone55
bone marrow61
brain44
cervix123
connective tissue93
ear124
embryonic tissue18
esophagus99
eye43
heart11
intestine34
kidney42
liver29
lung44
lymph112
lymph node55
mammary gland33
mouth30
muscle56
ovary29
pancreas32
pharynx24
pituitary gland60
placenta28
prostate10
salivary gland148
skin9
spleen93
stomach52
testis119
thymus100
thyroid21
trachea57
uterus77
vascular96
Health State
TissuesTPM*
normal50
bladder carcinoma56
breast (mammary gland) tumor42
cervical tumor86
chondrosarcoma72
colorectal tumor8
esophageal tumor115
gastrointestinal tumor25
germ cell tumor56
glioma27
head and neck tumor29
kidney tumor43
leukemia95
liver tumor31
lung tumor38
lymphoma138
non-neoplasia51
ovarian tumor13
pancreatic tumor19
primitive neuroectodermal tumor of the CNS94
retinoblastoma21
soft tissue/muscle tissue tumor95
uterine tumor88
Developmental Stage
TissuesTPM*
adult41
blastocyst32
fetus35
juvenile89
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue12.6
adrenal gland19.2
appendix23.1
bone marrow30.2
cerebral cortex10.5
colon21.5
duodenum19
esophagus15.9
gallbladder15
heart muscle15.3
kidney17.1
liver14.5
lung14.8
lymph node34.5
ovary13.2
pancreas10
placenta14.8
prostate18.9
salivary gland14.6
skin13.6
small intestine18.6
spleen22.5
stomach19.8
testis65
thyroid gland17.2
urinary bladder22.7
Tissues
TissuesExpression level
adrenal glandHigh
appendixHigh
bone marrowLow
breastHigh
bronchusHigh
cerebellumMedium
cerebral cortexMedium
cervix, uterineLow
colonMedium
duodenumHigh
endometrium 1Medium
endometrium 2Medium
epididymisMedium
esophagusLow
fallopian tubeHigh
gallbladderHigh
heart muscleMedium
hippocampusLow
kidneyHigh
lateral ventricleMedium
liverHigh
lungHigh
lymph nodeMedium
nasopharynxMedium
ovaryLow
pancreasHigh
parathyroid glandHigh
placentaMedium
prostateHigh
rectumHigh
salivary glandHigh
seminal vesicleHigh
skeletal muscleMedium
small intestineMedium
smooth muscleMedium
soft tissue 1Medium
soft tissue 2Low
spleenMedium
stomach 1High
stomach 2High
testisHigh
thyroid glandHigh
tonsilHigh
urinary bladderMedium
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*610661, gene) N-glycanase 1; NGLY1OMIM


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