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> Protein (NX_Q96IW7)
Protein (NX_Q96IW7)
Protein
Gene SymbolSEC22A to neXtProt (NX_Q96IW7)
DescriptionVesicle-trafficking protein SEC22a
Chromosome3
Location3q21.1 (122920774 ~ 122992977) to Ensembl
Sequene Features : Isoforms 1, Variants 35, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.vesicle fusion with Golgi apparatus
.protein transport
.ER to Golgi vesicle-mediated transport
.SNAP receptor activity
.transporter activity
.SNARE binding
.SNARE complex
.integral component of membrane
.endoplasmic reticulum membrane
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
1 35 4
2014-09-19protein level
1 27 4
2014-05-27protein level
1 27 4
2014-02-25protein level
1 27 4
2013-12-09protein level
1 19 4
2013-11-01protein level
1 18 4
2013-09-12protein level
1 18 3
2013-08-17protein level
1 18 3
2013-07-15protein level
1 10 3
2013-06-11protein level
1 10 3
2013-02-12protein level
1 4 3
2012-12-20protein level
1 4 3
2012-10-30protein level
1 4 3
2012-10-07protein level
1 4 3
2012-08-24protein level
1 4 3
2012-07-28protein level
1 4 3
2012-06-08protein level
1 8 3
2012-05-07protein level
1 7 3
2012-04-10protein level
1 7 3
2012-01-13protein level
1 10 3
2011-12-20protein level
1 10 3
2011-11-11protein level
1 10 3
2011-08-23protein level
1 10 3
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q96IW7-1
11 0 0 34924.4036
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-8652744,EBI-359299 ERLIN1  
  .ER-associated ubiquitin-dependent protein catabolic process .N/A .protein complex
.integral component of membrane
.endoplasmic reticulum membrane
.endoplasmic reticulum
2 EBI-8652744,EBI-10197617 SFTPC  
  .cellular response to nitric oxide
.cellular response to mechanical stimulus
.response to growth factor
  + 11 more...
.N/A .alveolar lamellar body
.multivesicular body
.extracellular space
3 EBI-8652744,EBI-1776976 MSR1  
  .cellular response to organic cyclic compound
.lipoprotein transport
.plasma lipoprotein particle clearance
  + 4 more...
.low-density lipoprotein particle binding
.scavenger receptor activity
.low-density lipoprotein particle
.endocytic vesicle membrane
.integral component of plasma membrane
  + 3 more...
4 EBI-8652744,EBI-744942 STX4  
  .positive regulation of protein localization to cell surface
.positive regulation of protein localization to plasma membrane
.regulation of extrinsic apoptotic signaling pathway via death domain receptors
  + 21 more...
.sphingomyelin phosphodiesterase activator activity
.SNAP receptor activity
.SNARE binding
.extracellular exosome
.perinuclear region of cytoplasm
.synapse
  + 19 more...
5 EBI-8652744,EBI-740376 DTX2  
  .protein ubiquitination
.Notch signaling pathway
.ligase activity
.zinc ion binding
.nuclear membrane
.cytoplasm
.nucleoplasm
6 EBI-8652744,EBI-7131783 SYNE4  
  .establishment of epithelial cell apical/basal polarity .N/A .LINC complex
.integral component of nuclear outer membrane
7 EBI-8652744,EBI-529425 EDA  
  .positive regulation of canonical Wnt signaling pathway
.trachea gland development
.hair follicle placode formation
  + 11 more...
.receptor binding .apical part of cell
.intracellular membrane-bounded organelle
.integral component of membrane
  + 7 more...
8 EBI-8652744,EBI-743099 FATE1  
  .N/A .N/A .integral component of membrane
.endoplasmic reticulum
9 EBI-8652744,EBI-348482 RNF5  
  .regulation of autophagic vacuole assembly
.ER-associated misfolded protein catabolic process
.protein K48-linked ubiquitination
  + 5 more...
.ligase activity
.zinc ion binding
.ubiquitin-protein transferase activity
.mitochondrial membrane
.integral component of membrane
.endoplasmic reticulum membrane
10 EBI-8652744,EBI-8649725 TMEM79  
  .cornification
.establishment of skin barrier
.positive regulation of epidermis development
  + 4 more...
.N/A .trans-Golgi network membrane
.integral component of membrane
.lysosomal membrane
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
ascites50
bladder66
blood57
bone55
brain28
cervix41
connective tissue20
embryonic tissue23
esophagus148
eye9
heart22
intestine21
kidney18
liver43
lung32
lymph node33
mammary gland33
mouth105
muscle28
ovary9
pancreas28
parathyroid145
pharynx24
placenta17
prostate26
salivary gland49
skin23
spleen18
stomach52
testis36
thymus37
tonsil58
trachea96
uterus34
vascular38
Health State
TissuesTPM*
normal37
bladder carcinoma113
cervical tumor57
chondrosarcoma48
colorectal tumor44
esophageal tumor173
gastrointestinal tumor42
germ cell tumor18
head and neck tumor52
kidney tumor14
leukemia42
liver tumor20
lung tumor19
lymphoma13
pancreatic tumor19
primitive neuroectodermal tumor of the CNS23
prostate cancer28
retinoblastoma21
skin tumor7
soft tissue/muscle tissue tumor23
uterine tumor44
Developmental Stage
TissuesTPM*
adult28
blastocyst65
fetus53
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue10.5
adrenal gland11.8
appendix10.6
bone marrow4.3
cerebral cortex8.6
colon12.1
duodenum7.4
esophagus13.1
gallbladder13.5
heart muscle8.6
kidney10.7
liver10.4
lung10.3
lymph node13
ovary12.2
pancreas4.7
placenta13.6
prostate10.8
salivary gland6.6
skin11.5
small intestine7.2
spleen8.1
stomach10.7
testis24.8
thyroid gland12.7
urinary bladder14.2
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*612442, gene) Secretion deficient 22, s. cerevisiae, homolog of, a; SEC22AOMIM


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