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> Protein (NX_Q96J02)
Protein (NX_Q96J02)
Protein
Gene SymbolITCH to neXtProt (NX_Q96J02)
DescriptionE3 ubiquitin-protein ligase Itchy homolog
Chromosome20
Location20q11.22 (32951041 ~ 33099198) to Ensembl
Sequene Features : Isoforms 3, Variants 86, PTMs 14 to neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.regulation of protein deubiquitination
.protein K48-linked ubiquitination
.protein K63-linked ubiquitination
  + 21 more...
.ubiquitin protein ligase activity
.CXCR chemokine receptor binding
.ribonucleoprotein complex binding
  + 2 more...
.extracellular exosome
.cytoplasmic vesicle
.membrane
  + 5 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
3 86 14
2014-09-19protein level
3 61 14
2014-05-27protein level
3 61 16
2014-02-25protein level
3 61 16
2013-12-09protein level
3 48 16
2013-11-01protein level
3 47 11
2013-09-12protein level
3 47 11
2013-08-17protein level
3 47 11
2013-07-15protein level
3 33 10
2013-06-11protein level
3 33 10
2013-02-12protein level
3 16 30
2012-12-20protein level
3 16 30
2012-10-30protein level
2 17 20
2012-10-07protein level
2 17 10
2012-08-24protein level
2 16 10
2012-07-28protein level
2 16 10
2012-06-08protein level
2 20 10
2012-05-07protein level
2 9 10
2012-04-10protein level
2 9 10
2012-01-13protein level
2 13 10
2011-12-20protein level
2 13 10
2011-11-11protein level
2 13 8
2011-08-23protein level
2 13 4
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q96J02-1
3 36 6 102737.8083
NX_Q96J02-2
0 37 6 98613.8136
NX_Q96J02-3
0 30 6 86443.5271
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-1564678,EBI-389619 TP73  
  .positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
.negative regulation of cardiac muscle cell proliferation
.protein tetramerization
  + 31 more...
.metal ion binding
.transcription regulatory region DNA binding
.identical protein binding
  + 10 more...
.intracellular membrane-bounded organelle
.cell junction
.cytosol
  + 5 more...
2 EBI-1564678,EBI-308084 GLI1  
  .negative regulation of canonical Wnt signaling pathway
.notochord regression
.digestive tract morphogenesis
  + 17 more...
.metal ion binding
.transcription regulatory region DNA binding
.RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity
  + 2 more...
.ciliary base
.ciliary tip
.primary cilium
  + 5 more...
3 EBI-1564678,EBI-77642 TP53BP2  
  .positive regulation of execution phase of apoptosis
.intrinsic apoptotic signaling pathway by p53 class mediator
.negative regulation of cell cycle
  + 7 more...
.NF-kappaB binding
.identical protein binding
.SH3/SH2 adaptor activity
.p53 binding
.perinuclear region of cytoplasm
.cytoplasm
.nucleus
4 EBI-1564678,EBI-2801236 SGK3  
  .transmembrane transport
.regulation of sequence-specific DNA binding transcription factor activity
.regulation of cell proliferation
  + 5 more...
.phosphatidylinositol binding
.chloride channel regulator activity
.sodium channel regulator activity
  + 5 more...
.recycling endosome
.cytoplasmic membrane-bounded vesicle
.cytosol
.early endosome
5 EBI-1564678,EBI-3239392 PI4K2A  
  .activation of mitophagy in response to mitochondrial depolarization
.phosphatidylinositol phosphorylation
.small molecule metabolic process
  + 2 more...
.AP-3 adaptor complex binding
.ATP binding
.1-phosphatidylinositol 4-kinase activity
.magnesium ion binding
.membrane raft
.host cell presynaptic membrane
.neuronal cell body
  + 15 more...
6 EBI-1564678,EBI-2117940 CYLD  
  .regulation of intrinsic apoptotic signaling pathway
.positive regulation of extrinsic apoptotic signaling pathway
.regulation of cilium assembly
  + 16 more...
.proline-rich region binding
.Lys63-specific deubiquitinase activity
.protein kinase binding
  + 2 more...
.ciliary tip
.perinuclear region of cytoplasm
.ciliary basal body
  + 6 more...
7 EBI-1564678,EBI-396669 RNF11  
  .protein autoubiquitination
.protein ubiquitination involved in ubiquitin-dependent protein catabolic process
.zinc ion binding
.ubiquitin-protein transferase activity
.DNA binding
.extracellular exosome
.recycling endosome
.early endosome
  + 2 more...
8 EBI-1564678,EBI-77848 SNX9  
  .membrane tubulation
.lipid tube assembly
.positive regulation of membrane protein ectodomain proteolysis
  + 11 more...
.Arp2/3 complex binding
.protein homodimerization activity
.phosphatidylinositol binding
  + 2 more...
.extracellular exosome
.extrinsic component of cytoplasmic side of plasma membrane
.cytoplasmic vesicle membrane
  + 7 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adrenal gland30
ascites25
blood40
bone27
brain31
connective tissue33
embryonic tissue42
esophagus297
eye19
heart22
intestine81
kidney52
larynx170
liver43
lung50
lymph node22
mammary gland92
mouth181
muscle112
pancreas14
parathyroid48
pharynx49
placenta45
prostate5
skin18
spleen18
stomach31
testis64
thymus75
thyroid21
trachea193
uterus38
vascular58
Health State
TissuesTPM*
normal39
adrenal tumor79
breast (mammary gland) tumor128
chondrosarcoma24
colorectal tumor142
esophageal tumor347
gastrointestinal tumor25
germ cell tumor68
glioma27
head and neck tumor127
kidney tumor29
leukemia42
liver tumor10
lung tumor29
non-neoplasia20
primitive neuroectodermal tumor of the CNS7
retinoblastoma21
skin tumor7
soft tissue/muscle tissue tumor47
uterine tumor22
Developmental Stage
TissuesTPM*
adult49
embryoid body42
blastocyst48
neonate32
fetus39
juvenile35
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue16
adrenal gland15.8
appendix19.4
bone marrow16.8
cerebral cortex20.5
colon19.9
duodenum14.6
esophagus38.6
gallbladder17.6
heart muscle16.2
kidney19.1
liver25.6
lung14.8
lymph node20.2
ovary18.5
pancreas9
placenta24.3
prostate15.5
salivary gland12.9
skin10.9
small intestine18.6
spleen16.8
stomach19.4
testis40.1
thyroid gland26.9
urinary bladder25.5
Tissues
TissuesExpression level
adrenal glandMedium
appendixMedium
bone marrowMedium
breastMedium
bronchusMedium
cerebellumMedium
cerebral cortexHigh
cervix, uterineLow
colonMedium
duodenumHigh
endometrium 1Medium
endometrium 2Medium
epididymisMedium
esophagusLow
fallopian tubeMedium
gallbladderMedium
heart muscleMedium
hippocampusHigh
kidneyMedium
lateral ventricleMedium
liverMedium
lungMedium
lymph nodeHigh
nasopharynxMedium
oral mucosaLow
ovaryMedium
pancreasHigh
parathyroid glandMedium
placentaHigh
prostateMedium
rectumMedium
salivary glandLow
seminal vesicleMedium
skeletal muscleHigh
skin 1Low
skin 2Medium
small intestineHigh
smooth muscleMedium
soft tissue 1Low
soft tissue 2Low
spleenHigh
stomach 1High
stomach 2High
testisMedium
thyroid glandMedium
tonsilHigh
urinary bladderMedium
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*606409, gene) Itchy e3 ubiquitin protein ligase, mouse, homolog of; ITCHOMIM
2(#613385, phenotype) Autoimmune disease, syndromic multisystemOMIM


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