Home| Contact Us

HOME SEARCH STATISTICS
> Protein (NX_Q96JB5)
Protein (NX_Q96JB5)
Protein
Gene SymbolCDK5RAP3 to neXtProt (NX_Q96JB5)
DescriptionCDK5 regulatory subunit-associated protein 3
Chromosome17
Location17q21.32 (46045176 ~ 46059140) to Ensembl
Sequene Features : Isoforms 4, Variants 60, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.negative regulation of cellular protein catabolic process
.positive regulation of signal transduction by p53 class mediator
.positive regulation of protein localization to nucleus
  + 13 more...
.MDM2/MDM4 family protein binding
.NF-kappaB binding
.ubiquitin-like protein ligase binding
  + 2 more...
.protein complex
.membrane
.endomembrane system
  + 3 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
4 60 2
2014-09-19protein level
4 48 2
2014-05-27protein level
3 47 2
2014-02-25protein level
3 47 2
2013-12-09protein level
3 32 2
2013-11-01protein level
3 28 2
2013-09-12protein level
3 28 2
2013-08-17protein level
3 28 2
2013-07-15protein level
3 24 0
2013-06-11protein level
3 24 0
2013-02-12protein level
3 12 0
2012-12-20protein level
3 12 0
2012-10-30protein level
3 17 0
2012-10-07protein level
3 17 0
2012-08-24protein level
3 16 0
2012-07-28protein level
3 16 0
2012-06-08protein level
3 4 0
2012-05-07protein level
3 4 0
2012-04-10protein level
3 4 0
2012-01-13protein level
3 4 0
2011-12-20protein level
3 4 0
2011-11-11protein level
3 4 0
2011-08-23protein level
3 4 0
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q96JB5-1
1 25 0 56884.8525
NX_Q96JB5-2
1 20 0 46321.3463
NX_Q96JB5-3
0 13 0 31180.9417
NX_Q96JB5-4
3 25 0 59551.2589
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-718818,EBI-744771 FKBP6  
  .chaperone-mediated protein folding
.DNA methylation involved in gamete generation
.piRNA metabolic process
  + 6 more...
.Hsp90 protein binding
.FK506 binding
.peptidyl-prolyl cis-trans isomerase activity
.cytosol
.endoplasmic reticulum membrane
.cytoplasm
.synaptonemal complex
2 EBI-718818,EBI-73886 RELA  
  .negative regulation of extrinsic apoptotic signaling pathway
.positive regulation of miRNA metabolic process
.negative regulation of NIK/NF-kappaB signaling
  + 64 more...
.repressing transcription factor binding
.NF-kappaB binding
.protein N-terminus binding
  + 20 more...
.NF-kappaB complex
.I-kappaB/NF-kappaB complex
.cytosol
  + 4 more...
3 EBI-718818,EBI-308511 TSPYL4  
  .nucleosome assembly .N/A .nucleus
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue155
adrenal gland91
bladder368
blood229
bone69
bone marrow102
brain234
cervix247
connective tissue167
embryonic tissue183
esophagus446
eye158
heart122
intestine215
kidney132
larynx85
liver219
lung77
lymph180
lymph node144
mammary gland218
mouth226
muscle56
nerve257
ovary187
pancreas107
pharynx220
pituitary gland60
placenta197
prostate142
skin128
spleen374
stomach219
testis268
thymus1003
thyroid257
trachea96
umbilical cord72
uterus262
vascular38
Health State
TissuesTPM*
normal183
bladder carcinoma227
breast (mammary gland) tumor322
cervical tumor202
chondrosarcoma36
colorectal tumor195
esophageal tumor405
gastrointestinal tumor118
germ cell tumor60
glioma111
head and neck tumor179
kidney tumor188
leukemia317
liver tumor354
lung tumor136
lymphoma263
non-neoplasia217
ovarian tumor183
pancreatic tumor180
primitive neuroectodermal tumor of the CNS314
prostate cancer96
retinoblastoma215
skin tumor103
soft tissue/muscle tissue tumor55
uterine tumor488
Developmental Stage
TissuesTPM*
adult150
embryoid body85
blastocyst244
neonate32
fetus104
infant297
juvenile305
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue44.7
adrenal gland68.3
appendix97.8
bone marrow90.7
cerebral cortex52
colon59.1
duodenum103
esophagus50.1
gallbladder94.7
heart muscle40.7
kidney47.6
liver35.4
lung82.6
lymph node126.7
ovary119.4
pancreas72.7
placenta58.3
prostate100.3
salivary gland107.7
skin88.8
small intestine92.4
spleen118.7
stomach103.4
testis90.1
thyroid gland111.9
urinary bladder78.2
Tissues
TissuesExpression level
adrenal glandMedium
appendixMedium
bone marrowMedium
breastMedium
bronchusHigh
cerebellumMedium
cerebral cortexMedium
cervix, uterineMedium
colonHigh
duodenumHigh
endometrium 1Medium
endometrium 2Medium
epididymisHigh
esophagusMedium
fallopian tubeMedium
gallbladderHigh
heart muscleMedium
hippocampusMedium
kidneyMedium
lateral ventricleLow
liverLow
lungMedium
lymph nodeMedium
nasopharynxHigh
oral mucosaMedium
ovaryMedium
pancreasHigh
parathyroid glandMedium
placentaHigh
prostateMedium
rectumMedium
salivary glandMedium
seminal vesicleHigh
skeletal muscleLow
skin 1Medium
skin 2Medium
small intestineHigh
smooth muscleLow
soft tissue 1Low
soft tissue 2Medium
spleenLow
stomach 1High
stomach 2High
testisHigh
thyroid glandMedium
tonsilMedium
urinary bladderMedium
vaginaLow
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*608202, gene) Cdk5 regulatory subunit-associated protein 3; CDK5RAP3OMIM


#424, YPRC/BPRC, Industry-University Research Center, Yonsei Univ., Seodaemun-gu, Seoul, Korea, 120-749
Tel: +82-2-2123-6626, Fax: +82-2-393-6589
2014-2019 (C) Yonsei Proteome Research Center