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> Protein (NX_Q96JC9)
Protein (NX_Q96JC9)
Protein
Gene SymbolEAF1 to neXtProt (NX_Q96JC9)
DescriptionELL-associated factor 1
Chromosome3
Location3p25.1 (15468862 ~ 15484120) to Ensembl
Sequene Features : Isoforms 2, Variants 30, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.regulation of transcription, DNA-templated
.transcription, DNA-templated
.N/A .ELL-EAF complex
.nuclear speck
.Cajal body
  + 3 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
2 30 2
2014-09-19protein level
1 22 2
2014-05-27protein level
1 22 6
2014-02-25protein level
1 22 6
2013-12-09protein level
1 20 6
2013-11-01protein level
1 19 5
2013-09-12protein level
1 19 6
2013-08-17protein level
1 19 6
2013-07-15protein level
1 17 6
2013-06-11protein level
1 17 6
2013-02-12protein level
1 12 8
2012-12-20protein level
1 12 8
2012-10-30protein level
1 11 8
2012-10-07protein level
1 11 8
2012-08-24protein level
1 10 8
2012-07-28protein level
1 10 8
2012-06-08protein level
1 12 8
2012-05-07protein level
1 10 8
2012-04-10protein level
1 10 8
2012-01-13protein level
1 6 8
2011-12-20protein level
1 6 8
2011-11-11protein level
1 6 8
2011-08-23protein level
1 6 8
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q96JC9-1
5 4 1 29024.0241
NX_Q96JC9-2
1 4 1 17712.2851
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-769261,EBI-727004 SDCBP  
  .positive regulation of extracellular exosome assembly
.positive regulation of exosomal secretion
.ephrin receptor signaling pathway
  + 9 more...
.protein N-terminus binding
.protein heterodimerization activity
.syndecan binding
  + 4 more...
.blood microparticle
.extracellular exosome
.melanosome
  + 12 more...
2 EBI-769261,EBI-10176632 ZBTB14  
  .negative regulation of transcription, DNA-templated
.transcription from RNA polymerase II promoter
.negative regulation of transcription from RNA polymerase II promoter
.metal ion binding
.transcription regulatory region DNA binding
.sequence-specific DNA binding
  + 2 more...
.cytoplasm
.nucleoplasm
.nucleus
3 EBI-769261,EBI-394392 MED26  
  .gene expression
.transcription initiation from RNA polymerase II promoter
.regulation of transcription from RNA polymerase II promoter
.transcription coactivator activity
.DNA binding
.RNA polymerase II transcription cofactor activity
.mediator complex
.nucleoplasm
4 EBI-769261,EBI-355546 PSME3  
  .negative regulation of extrinsic apoptotic signaling pathway
.positive regulation of canonical Wnt signaling pathway
.negative regulation of canonical Wnt signaling pathway
  + 24 more...
.MDM2/MDM4 family protein binding
.endopeptidase activator activity
.identical protein binding
.p53 binding
.membrane
.proteasome activator complex
.cytosol
  + 4 more...
5 EBI-769261,EBI-717810 AES  
  .positive regulation of anoikis
.negative regulation of canonical Wnt signaling pathway
.response to interleukin-1
  + 12 more...
.transcription corepressor activity .nucleus
6 EBI-769261,EBI-717422 TFCP2  
  .regulation of transcription from RNA polymerase II promoter
.transcription, DNA-templated
.sequence-specific DNA binding
.protein C-terminus binding
.sequence-specific DNA binding transcription factor activity
.DNA binding
.nucleus
7 EBI-769261,EBI-10181188 BEND7  
  .N/A .N/A .extracellular exosome
8 EBI-769261,EBI-742887 CEP76  
  .regulation of centriole replication
.organelle organization
.mitotic cell cycle
.G2/M transition of mitotic cell cycle
.N/A .protein complex
.cytosol
.centriole
.centrosome
9 EBI-769261,EBI-2548751 MIPOL1  
  .N/A .N/A .nucleus
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
ascites50
blood32
bone69
brain23
connective tissue33
embryonic tissue14
eye14
intestine21
kidney4
liver29
lung26
lymph22
lymph node89
mammary gland66
mouth30
muscle37
ovary49
pancreas42
pituitary gland60
placenta24
prostate5
skin37
testis66
thymus12
thyroid42
trachea57
uterus21
Health State
TissuesTPM*
normal25
bladder carcinoma56
breast (mammary gland) tumor107
chondrosarcoma60
colorectal tumor26
gastrointestinal tumor16
germ cell tumor53
glioma18
head and neck tumor29
leukemia21
liver tumor20
lung tumor9
lymphoma13
non-neoplasia20
ovarian tumor52
primitive neuroectodermal tumor of the CNS23
skin tumor47
soft tissue/muscle tissue tumor23
uterine tumor22
Developmental Stage
TissuesTPM*
adult36
blastocyst48
fetus17
infant42
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue11.1
adrenal gland9.1
appendix10.1
bone marrow37.9
cerebral cortex14.4
colon9.3
duodenum9.4
esophagus10.4
gallbladder11.6
heart muscle4.4
kidney10.1
liver10.5
lung8.2
lymph node10.4
ovary5.7
pancreas5.3
placenta11.7
prostate10
salivary gland5.1
skin6.6
small intestine9.2
spleen9.2
stomach11.7
testis11.6
thyroid gland12.1
urinary bladder9.4
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Disease
No.Disease DescriptionRef.
1(*608315, gene) Ell-associated factor 1; EAF1OMIM


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