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> Protein (NX_Q96JM7)
Protein (NX_Q96JM7)
Protein
Gene SymbolL3MBTL3 to neXtProt (NX_Q96JM7)
DescriptionLethal(3)malignant brain tumor-like protein 3
Chromosome6
Location6q23.1 (130334844 ~ 130462594) to Ensembl
Sequene Features : Isoforms 2, Variants 115, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.erythrocyte maturation
.granulocyte differentiation
.macrophage differentiation
  + 3 more...
.N/A .nucleus
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
2 115 5
2014-09-19protein level
2 97 5
2014-05-27protein level
2 97 5
2014-02-25protein level
2 94 5
2013-12-09protein level
2 73 5
2013-11-01protein level
2 67 4
2013-09-12protein level
2 67 4
2013-08-17protein level
2 67 4
2013-07-15protein level
2 44 4
2013-06-11protein level
2 44 4
2013-02-12protein level
2 18 4
2012-12-20protein level
2 16 4
2012-10-30protein level
2 23 4
2012-10-07protein level
2 23 2
2012-08-24protein level
2 20 2
2012-07-28protein level
2 20 2
2012-06-08protein level
2 20 2
2012-05-07protein level
2 15 2
2012-04-10protein level
2 15 2
2012-01-13protein level
2 7 2
2011-12-20protein level
2 7 2
2011-11-11protein level
2 7 2
2011-08-23protein level
2 7 2
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q96JM7-1
1 30 0 88279.9465
NX_Q96JM7-2
1 30 0 85701.7219
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-2686809,EBI-286285 THRA  
  .negative regulation of DNA-templated transcription, initiation
.Type I pneumocyte differentiation
.regulation of lipid catabolic process
  + 22 more...
.thyroid hormone binding
.transcription regulatory region DNA binding
.sequence-specific DNA binding
  + 9 more...
.cytosol
.nucleoplasm
.nucleus
2 EBI-2686809,EBI-372475 SNRPB  
  .activation of mitophagy in response to mitochondrial depolarization
.ncRNA metabolic process
.mRNA 3'-end processing
  + 9 more...
.histone pre-mRNA DCP binding
.poly(A) RNA binding
.histone pre-mRNA 3'end processing complex
.catalytic step 2 spliceosome
.U2-type prespliceosome
  + 14 more...
3 EBI-2686809,EBI-2622029 PDE6G  
  .positive regulation of G-protein coupled receptor protein signaling pathway
.positive regulation of epidermal growth factor receptor signaling pathway
.negative regulation of catalytic activity
  + 5 more...
.3',5'-cyclic-GMP phosphodiesterase activity
.cGMP binding
.enzyme inhibitor activity
.photoreceptor disc membrane
.plasma membrane
4 EBI-2686809,EBI-751145 SP100  
  .negative regulation of nucleic acid-templated transcription
.regulation of Fas signaling pathway
.regulation of extrinsic apoptotic signaling pathway via death domain receptors
  + 27 more...
.chromo shadow domain binding
.protein homodimerization activity
.identical protein binding
  + 7 more...
.nuclear periphery
.PML body
.cytoplasm
  + 3 more...
5 EBI-2686809,EBI-713568 MAPK9  
  .positive regulation of apoptotic signaling pathway
.cellular response to growth factor stimulus
.cellular response to tumor necrosis factor
  + 45 more...
.cysteine-type endopeptidase activator activity involved in apoptotic process
.transcription factor binding
.ATP binding
.JUN kinase activity
.cytosol
.mitochondrion
.nucleoplasm
6 EBI-2686809,EBI-1383852 PRKAA2  
  .regulation of energy homeostasis
.membrane organization
.fatty acid homeostasis
  + 31 more...
.[acetyl-CoA carboxylase] kinase activity
.[hydroxymethylglutaryl-CoA reductase (NADPH)] kinase activity
.metal ion binding
  + 7 more...
.AMP-activated protein kinase complex
.cytosol
.cytoplasm
.nucleoplasm
7 EBI-2686809,EBI-359527 POLR2L  
  .positive regulation of viral transcription
.negative regulation of gene expression, epigenetic
.innate immune response
  + 23 more...
.zinc ion binding
.DNA-directed RNA polymerase activity
.DNA binding
.cytosol
.DNA-directed RNA polymerase I complex
.DNA-directed RNA polymerase III complex
  + 3 more...
8 EBI-2686809,EBI-1181405 PRKAA1  
  .negative regulation of glucose import in response to insulin stimulus
.regulation of energy homeostasis
.response to camptothecin
  + 42 more...
.[acetyl-CoA carboxylase] kinase activity
.tau-protein kinase activity
.[hydroxymethylglutaryl-CoA reductase (NADPH)] kinase activity
  + 7 more...
.AMP-activated protein kinase complex
.apical plasma membrane
.cytosol
  + 4 more...
9 EBI-2686809,EBI-358049 BYSL  
  .cell proliferation
.female pregnancy
.cell adhesion
  + 2 more...
.poly(A) RNA binding .apical part of cell
.intracellular membrane-bounded organelle
.membrane
  + 3 more...
10 EBI-2686809,EBI-399257 MORF4L2  
  .positive regulation of striated muscle cell differentiation
.positive regulation of transcription from RNA polymerase II promoter
.regulation of growth
  + 4 more...
.N/A .nucleolus
.nucleoplasm
11 EBI-2686809,EBI-948354 TTC19  
  .mitochondrial respiratory chain complex III assembly
.cytokinesis
.N/A .midbody
.centrosome
.mitochondrial inner membrane
.mitochondrion
12 EBI-2686809,EBI-713786 PHC2  
  .cellular protein metabolic process
.post-translational protein modification
.protein sumoylation
  + 2 more...
.identical protein binding
.zinc ion binding
.DNA binding
.PRC1 complex
.PcG protein complex
.nucleoplasm
  + 2 more...
13 EBI-2686809,EBI-744695 BANP  
  .negative regulation of protein catabolic process
.protein localization to nucleus
.chromatin modification
  + 4 more...
.DNA binding .nucleoplasm
14 EBI-2686809,EBI-745767 PLEKHF1  
  .positive regulation of intrinsic apoptotic signaling pathway
.protein localization to plasma membrane
.vesicle organization
  + 3 more...
.phosphatidylinositol-4-phosphate binding
.metal ion binding
.phosphatidylinositol-3-phosphate binding
.phosphatidylinositol-5-phosphate binding
.perinuclear region of cytoplasm
.endosome membrane
.lysosomal membrane
  + 2 more...
15 EBI-2686809,EBI-742388 PLEKHF2  
  .protein transport .metal ion binding .early endosome membrane
.transport vesicle
.endoplasmic reticulum
16 EBI-2686809,EBI-10311409 NGB  
  .oxygen transport
.apoptotic process
.heme binding
.iron ion binding
.oxygen transporter activity
.perikaryon
.mitochondrion
17 EBI-2686809,EBI-6425205 ASB6  
  .intracellular signal transduction
.protein ubiquitination
.N/A .cytoplasm
18 EBI-2686809,EBI-399246 MORF4L1  
  .histone H2A acetylation
.histone H4 acetylation
.regulation of growth
  + 6 more...
.protein N-terminus binding
.chromatin binding
.NuA4 histone acetyltransferase complex
.Sin3 complex
.nucleoplasm
19 EBI-2686809,EBI-10281601 OAZ3  
  .negative regulation of polyamine transmembrane transport
.positive regulation of protein catabolic process
.small molecule metabolic process
  + 6 more...
.putrescine transmembrane transporter activity
.ornithine decarboxylase inhibitor activity
.blood microparticle
.sperm flagellum
.cytosol
.nucleus
20 EBI-2686809,EBI-372521 LSM4  
  .activation of mitophagy in response to mitochondrial depolarization
.exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay
.gene expression
  + 4 more...
.poly(A) RNA binding .small nuclear ribonucleoprotein complex
.cytosol
.U6 snRNP
.spliceosomal complex
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
blood8
brain9
connective tissue13
embryonic tissue23
eye9
intestine38
kidney14
larynx127
lymph22
lymph node22
mammary gland13
placenta10
prostate15
skin4
testis13
thymus25
trachea19
uterus17
vascular19
Health State
TissuesTPM*
normal12
breast (mammary gland) tumor10
chondrosarcoma12
colorectal tumor44
glioma9
head and neck tumor22
kidney tumor14
leukemia31
lymphoma27
ovarian tumor13
prostate cancer28
soft tissue/muscle tissue tumor7
Developmental Stage
TissuesTPM*
adult14
embryoid body28
blastocyst32
fetus8
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue3.7
adrenal gland11.6
appendix11
bone marrow4.8
cerebral cortex3.3
colon4.4
duodenum2.4
esophagus2.3
gallbladder5.7
heart muscle1.6
kidney5.2
liver2.6
lung4.2
lymph node10.7
ovary9
pancreas1.5
placenta4.9
prostate7.1
salivary gland3.1
skin1.9
small intestine3.3
spleen12.1
stomach3.2
testis7.2
thyroid gland6.1
urinary bladder5.8
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected


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