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> Protein (NX_Q96JN2)
Protein (NX_Q96JN2)
Protein
Gene SymbolCCDC136 to neXtProt (NX_Q96JN2)
DescriptionCoiled-coil domain-containing protein 136
Chromosome7
Location7q32.1 (128430811 ~ 128462186) to Ensembl
Sequene Features : Isoforms 4, Variants 125, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.N/A .N/A .integral component of membrane
.mitochondrion
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
4 125 0
2014-09-19protein level
4 105 0
2014-05-27protein level
4 105 0
2014-02-25protein level
4 91 0
2013-12-09protein level
4 61 0
2013-11-01protein level
4 58 0
2013-09-12protein level
4 58 0
2013-08-17protein level
4 58 0
2013-07-15transcript level
4 38 0
2013-06-11transcript level
4 38 0
2013-02-12transcript level
4 13 0
2012-12-20transcript level
4 11 0
2012-10-30transcript level
4 24 0
2012-10-07transcript level
4 24 0
2012-08-24transcript level
4 24 0
2012-07-28transcript level
4 24 0
2012-06-08transcript level
4 4 0
2012-05-07transcript level
4 4 0
2012-04-10transcript level
4 4 0
2012-01-13transcript level
4 4 0
2011-12-20transcript level
4 11 0
2011-11-11transcript level
4 11 0
2011-08-23protein level
4 11 0
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q96JN2-1
1 56 0 133960.7805
NX_Q96JN2-2
1 50 0 111476.8443
NX_Q96JN2-3
4 18 0 49418.5392
NX_Q96JN2-4
1 57 0 134583.0001
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-10171416,EBI-750973 PSMD9  
  .positive regulation of canonical Wnt signaling pathway
.negative regulation of canonical Wnt signaling pathway
.proteasome regulatory particle assembly
  + 26 more...
.bHLH transcription factor binding
.transcription coactivator activity
.proteasome regulatory particle
.cytosol
.cytoplasm
  + 2 more...
2 EBI-10171416,EBI-1052532 CDK2AP1  
  .cell cycle
.DNA-dependent DNA replication
.positive regulation of protein phosphorylation
.DNA polymerase binding .perinuclear region of cytoplasm
.nucleus
3 EBI-10171416,EBI-751857 MAGEB4  
  .N/A .N/A .N/A
4 EBI-10171416,EBI-743272 USP2  
  .regulation of proteasomal protein catabolic process
.protein stabilization
.positive regulation of skeletal muscle tissue development
  + 11 more...
.metal ion binding
.ubiquitin protein ligase binding
.cyclin binding
  + 2 more...
.perinuclear region of cytoplasm
.cell cortex
.centrosome
  + 2 more...
5 EBI-10171416,EBI-10192902 FAM107A  
  .regulation of cell growth .N/A .neuron projection
.nucleus
6 EBI-10171416,EBI-1757866 MOS  
  .negative regulation of metaphase/anaphase transition of meiotic cell cycle
.establishment of meiotic spindle orientation
.protein autophosphorylation
  + 6 more...
.ATP binding
.MAP kinase kinase kinase activity
.protein serine/threonine kinase activity
.cytoplasm
7 EBI-10171416,EBI-726527 TNNT1  
  .negative regulation of muscle contraction
.slow-twitch skeletal muscle fiber contraction
.muscle filament sliding
.skeletal muscle contraction
.tropomyosin binding .troponin complex
.cytosol
8 EBI-10171416,EBI-10177272 ZNF250  
  .regulation of transcription, DNA-templated
.transcription, DNA-templated
.metal ion binding
.sequence-specific DNA binding transcription factor activity
.DNA binding
.nucleus
9 EBI-10171416,EBI-717634 ZNF20  
  .regulation of transcription, DNA-templated
.transcription, DNA-templated
.metal ion binding
.DNA binding
.nucleus
10 EBI-10171416,EBI-745213 AQP1  
  .cation transmembrane transport
.maintenance of symbiont-containing vacuole by host
.ammonium transmembrane transport
  + 60 more...
.carbon dioxide transmembrane transporter activity
.nitric oxide transmembrane transporter activity
.transmembrane transporter activity
  + 8 more...
.extracellular exosome
.apical part of cell
.axon terminus
  + 12 more...
11 EBI-10171416,EBI-359793 TXLNA  
  .activation of mitophagy in response to mitochondrial depolarization
.B cell activation
.cell proliferation
.exocytosis
.high molecular weight B cell growth factor receptor binding
.cytokine activity
.membrane
.cytoplasm
.extracellular region
12 EBI-10171416,EBI-355815 ATP5O  
  .small molecule metabolic process
.cellular metabolic process
.mitochondrial ATP synthesis coupled proton transport
  + 3 more...
.proton-transporting ATP synthase activity, rotational mechanism
.transmembrane transporter activity
.drug binding
.transporter activity
.extracellular exosome
.plasma membrane
.mitochondrial proton-transporting ATP synthase complex
  + 3 more...
13 EBI-10171416,EBI-308629 HDAC4  
  .histone H4 deacetylation
.histone H3 deacetylation
.response to interleukin-1
  + 29 more...
.NAD-dependent histone deacetylase activity (H3-K18 specific)
.repressing transcription factor binding
.NAD-dependent histone deacetylase activity (H4-K16 specific)
  + 12 more...
.actomyosin
.A band
.neuromuscular junction
  + 7 more...
14 EBI-10171416,EBI-358049 BYSL  
  .cell proliferation
.female pregnancy
.cell adhesion
  + 2 more...
.poly(A) RNA binding .apical part of cell
.intracellular membrane-bounded organelle
.membrane
  + 3 more...
15 EBI-10171416,EBI-744685 RAB33A  
  .regulation of autophagic vacuole assembly
.Rab protein signal transduction
.antigen processing and presentation
  + 2 more...
.GTP binding
.GTPase activity
.plasma membrane
.Golgi apparatus
16 EBI-10171416,EBI-710310 TCEA2  
  .positive regulation of transcription from RNA polymerase II promoter
.regulation of DNA-templated transcription, elongation
.DNA-templated transcription, elongation
.zinc ion binding
.DNA binding
.transcription elongation factor complex
.centrosome
.nucleoplasm
17 EBI-10171416,EBI-3920053 ZSCAN26  
  .regulation of transcription, DNA-templated
.transcription, DNA-templated
.metal ion binding
.sequence-specific DNA binding transcription factor activity
.nucleic acid binding
.nucleus
18 EBI-10171416,EBI-719941 FAM161A  
  .response to stimulus
.cilium assembly
.visual perception
.N/A .ciliary basal body
.photoreceptor connecting cilium
.centrosome
.cytoplasm
19 EBI-10171416,EBI-740767 ZC2HC1C  
  .N/A .metal ion binding .N/A
20 EBI-10171416,EBI-2557469 PPP1R18  
  .N/A .N/A .cytoskeleton
.cytoplasm
21 EBI-10171416,EBI-10257016 ZNF572  
  .regulation of transcription, DNA-templated
.transcription, DNA-templated
.metal ion binding
.DNA binding
.nucleus
22 EBI-10171416,EBI-10247802 CCDC146  
  .N/A .N/A .centriole
23 EBI-10171416,EBI-1104570 CEP57L1  
  .microtubule anchoring .N/A .microtubule
.microtubule organizing center
.cytoplasm
24 EBI-10171416,EBI-10268138 JMY  
  .intrinsic apoptotic signaling pathway by p53 class mediator
.actin polymerization-dependent cell motility
.'de novo' actin filament nucleation
  + 6 more...
.transcription coactivator activity .cell leading edge
.cell junction
.plasma membrane
  + 4 more...
25 EBI-10171416,EBI-747505 C1orf216  
  .N/A .N/A .N/A
26 EBI-10171416,EBI-740727 ZNF417  
  .regulation of transcription, DNA-templated
.transcription, DNA-templated
.metal ion binding
.DNA binding
.nucleus
27 EBI-10171416,EBI-10273713 ZNF564  
  .regulation of transcription, DNA-templated
.transcription, DNA-templated
.metal ion binding
.DNA binding
.nucleus
28 EBI-10171416,EBI-10175300 CCHCR1  
  .cell differentiation
.multicellular organismal development
.protein export from nucleus
.N/A .centriole
.cytoplasm
.nucleus
29 EBI-10171416,EBI-399080 KAT5  
  .positive regulation of protein acetylation
.cellular response to estradiol stimulus
.positive regulation of transcription from RNA polymerase II promoter
  + 14 more...
.repressing transcription factor binding
.androgen receptor binding
.metal ion binding
  + 2 more...
.perinuclear region of cytoplasm
.NuA4 histone acetyltransferase complex
.Piccolo NuA4 histone acetyltransferase complex
  + 6 more...
30 EBI-10171416,EBI-455078 SMARCE1  
  .negative regulation of transcription, DNA-templated
.ATP-dependent chromatin remodeling
.metabolic process
  + 4 more...
.protein N-terminus binding
.ligand-dependent nuclear receptor binding
.N-acetyltransferase activity
  + 4 more...
.nBAF complex
.npBAF complex
.protein complex
  + 6 more...
31 EBI-10171416,EBI-726510 LENG1  
  .N/A .N/A .N/A
32 EBI-10171416,EBI-2514791 HAUS1  
  .cell division
.centrosome organization
.spindle assembly
.mitotic nuclear division
.N/A .HAUS complex
.microtubule
.centrosome
  + 2 more...
33 EBI-10171416,EBI-751267 PDLIM5  
  .regulation of dendritic spine morphogenesis
.regulation of synapse assembly
.actinin binding
.zinc ion binding
.protein kinase C binding
.actin binding
.postsynaptic membrane
.neuron projection
.cell junction
  + 5 more...
34 EBI-10171416,EBI-6427977 ZNF587  
  .regulation of transcription, DNA-templated
.transcription, DNA-templated
.metal ion binding
.DNA binding
.nucleus
35 EBI-10171416,EBI-2125614 KIFC3  
  .epithelial cell-cell adhesion
.zonula adherens maintenance
.metabolic process
  + 3 more...
.ATPase activity
.ATP binding
.microtubule motor activity
.extracellular exosome
.cytoplasmic vesicle membrane
.zonula adherens
  + 4 more...
36 EBI-10171416,EBI-744099 ENKD1  
  .N/A .N/A .microtubule cytoskeleton
.cytoplasmic microtubule
37 EBI-10171416,EBI-3916346 ASB7  
  .intracellular signal transduction
.protein ubiquitination
.N/A .N/A
38 EBI-10171416,EBI-712912 CBX8  
  .cellular protein metabolic process
.post-translational protein modification
.protein sumoylation
  + 3 more...
.methylated histone binding
.ubiquitin-protein transferase activity
.single-stranded RNA binding
.PRC1 complex
.PcG protein complex
.nucleoplasm
  + 3 more...
39 EBI-10171416,EBI-740641 HMG20A  
  .negative regulation of neuron differentiation
.regulation of transcription, DNA-templated
.transcription, DNA-templated
  + 3 more...
.sequence-specific DNA binding transcription factor activity
.chromatin binding
.DNA binding
.nucleus
40 EBI-10171416,EBI-10313866 C19orf66  
  .N/A .N/A .N/A
41 EBI-10171416,EBI-745520 ZNF581  
  .transcription from RNA polymerase II promoter
.regulation of transcription from RNA polymerase II promoter
.metal ion binding
.RNA polymerase II regulatory region sequence-specific DNA binding
.nucleus
42 EBI-10171416,EBI-713401 HMG20B  
  .positive regulation of neuron differentiation
.skeletal muscle cell differentiation
.negative regulation of protein sumoylation
  + 6 more...
.chromatin binding
.DNA binding
.chromosome
.nucleoplasm
43 EBI-10171416,EBI-1105361 ZNF230  
  .regulation of transcription, DNA-templated
.transcription, DNA-templated
.metal ion binding
.DNA binding
.nucleus
44 EBI-10171416,EBI-465781 BLOC1S6  
  .membrane fusion
.membrane organization
.positive regulation of pigment cell differentiation
  + 12 more...
.actin filament binding
.protein homodimerization activity
.identical protein binding
.syntaxin binding
.BLOC-1 complex
.transport vesicle
.extrinsic component of membrane
  + 4 more...
45 EBI-10171416,EBI-1105370 ZNF490  
  .regulation of transcription, DNA-templated
.transcription, DNA-templated
.metal ion binding
.sequence-specific DNA binding transcription factor activity
.DNA binding
.nucleus
46 EBI-10171416,EBI-2602396 ABT1  
  .small-subunit processome assembly
.spinal cord motor neuron differentiation
.transcription from RNA polymerase II promoter
  + 4 more...
.poly(A) RNA binding
.transcription coactivator activity
.DNA binding
.nucleotide binding
.nucleolus
.transcription factor complex
.nucleus
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
brain45
cervix41
connective tissue13
embryonic tissue14
eye90
kidney14
liver4
mammary gland6
muscle9
pharynx24
placenta7
skin9
testis133
thymus12
uterus8
vascular19
Health State
TissuesTPM*
normal36
breast (mammary gland) tumor10
cervical tumor57
chondrosarcoma24
germ cell tumor53
glioma27
head and neck tumor7
kidney tumor29
skin tumor7
uterine tumor11
Developmental Stage
TissuesTPM*
adult26
embryoid body28
blastocyst16
fetus41
infant85
juvenile17
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue1.7
adrenal gland7.6
appendix3.5
cerebral cortex26.2
colon8.7
duodenum1.8
esophagus3
gallbladder4.1
heart muscle5.8
lung1.7
lymph node3.5
ovary3.2
placenta1.4
prostate18.2
salivary gland1.4
skin1
small intestine3.1
spleen1.4
stomach2
testis214.6
thyroid gland1.5
urinary bladder4
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*611902, gene) Coiled-coil domain-containing protein 136; CCDC136OMIM


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