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> Protein (NX_Q96JZ2)
Protein (NX_Q96JZ2)
Protein
Gene SymbolHSH2D to neXtProt (NX_Q96JZ2)
DescriptionHematopoietic SH2 domain-containing protein
Chromosome19
Location19p13.12 (16244838 ~ 16269386) to Ensembl
Sequene Features : Isoforms 2, Variants 25, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.negative regulation of mitochondrial depolarization
.T cell activation
.positive regulation of signal transduction
.negative regulation of B cell apoptotic process
.N/A .cytosol
.mitochondrion
.nucleus
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
2 25 0
2014-09-19protein level
2 17 0
2014-05-27protein level
2 17 0
2014-02-25protein level
2 16 0
2013-12-09protein level
2 12 0
2013-11-01protein level
2 12 0
2013-09-12protein level
2 12 0
2013-08-17protein level
2 12 0
2013-07-15protein level
2 5 0
2013-06-11protein level
2 5 0
2013-02-12protein level
2 4 0
2012-12-20protein level
2 6 0
2012-10-30protein level
2 6 0
2012-10-07protein level
2 6 0
2012-08-24protein level
2 6 0
2012-07-28protein level
2 6 0
2012-06-08protein level
2 8 0
2012-05-07protein level
2 8 0
2012-04-10protein level
2 8 0
2012-01-13protein level
2 8 0
2011-12-20protein level
2 8 0
2011-11-11protein level
2 8 0
2011-08-23protein level
2 8 0
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q96JZ2-1
4 15 0 38977.3449
NX_Q96JZ2-2
1 15 0 32683.1661
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-3919324,EBI-1379503 KIT  
  .melanocyte adhesion
.melanocyte migration
.cellular response to thyroid hormone stimulus
  + 69 more...
.metal ion binding
.protein homodimerization activity
.cytokine binding
  + 5 more...
.mast cell granule
.integral component of membrane
.cytoplasmic side of plasma membrane
  + 5 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
bladder133
blood188
bone marrow184
brain2
esophagus49
intestine25
lung8
lymph67
lymph node122
mammary gland92
muscle9
pancreas9
placenta14
prostate26
spleen93
stomach41
thymus25
thyroid42
tonsil58
trachea38
Health State
TissuesTPM*
normal15
breast (mammary gland) tumor150
colorectal tumor8
esophageal tumor57
gastrointestinal tumor33
head and neck tumor14
leukemia190
lymphoma41
pancreatic tumor19
prostate cancer28
Developmental Stage
TissuesTPM*
adult16
fetus1
juvenile35
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue2.5
adrenal gland1.2
appendix31
bone marrow50.3
colon13.7
duodenum20.7
esophagus2.3
gallbladder8.8
liver1.2
lung8.2
lymph node39.8
pancreas3
placenta2.2
prostate7.8
salivary gland10.6
small intestine14.9
spleen37.6
stomach20.9
thyroid gland1.9
urinary bladder16.9
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*608349, gene) Hematopoietic sh2 domain-containing proteinOMIM


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