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> Protein (NX_Q96K21)
Protein (NX_Q96K21)
Protein
Gene SymbolZFYVE19 to neXtProt (NX_Q96K21)
DescriptionAbscission/NoCut checkpoint regulator
Chromosome15
Location15q15.1 (41099284 ~ 41106767) to Ensembl
Sequene Features : Isoforms 4, Variants 50, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.cell division
.negative regulation of cytokinesis
.abscission
.cell cycle
.phosphatidylinositol-3-phosphate binding
.zinc ion binding
.cleavage furrow
.midbody
.centrosome
.cytoplasm
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
4 50 5
2014-09-19protein level
4 37 5
2014-05-27protein level
4 37 5
2014-02-25protein level
4 37 5
2013-12-09protein level
4 22 5
2013-11-01protein level
4 22 4
2013-09-12protein level
4 22 4
2013-08-17protein level
4 22 4
2013-07-15protein level
4 16 4
2013-06-11protein level
4 16 4
2013-02-12protein level
3 9 12
2012-12-20protein level
3 13 12
2012-10-30protein level
3 14 12
2012-10-07protein level
3 14 4
2012-08-24protein level
3 14 4
2012-07-28protein level
3 14 4
2012-06-08protein level
3 15 4
2012-05-07protein level
3 14 4
2012-04-10protein level
3 14 4
2012-01-13protein level
3 10 4
2011-12-20protein level
3 10 4
2011-11-11protein level
3 10 3
2011-08-23protein level
3 10 3
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q96K21-1
0 23 0 51514.1118
NX_Q96K21-2
4 19 0 50502.543
NX_Q96K21-3
1 20 0 43906.1866
NX_Q96K21-4
0 13 0 32943.023
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-10187928,EBI-2514459 VPS4B  
  .positive regulation of viral life cycle
.positive regulation of centriole elongation
.positive regulation of exosomal secretion
  + 27 more...
.protein homodimerization activity
.identical protein binding
.ATPase activity, coupled
  + 3 more...
.Flemming body
.extracellular exosome
.late endosome membrane
  + 7 more...
2 EBI-6448240,EBI-466029 HTT  
  .negative regulation of extrinsic apoptotic signaling pathway
.iron ion homeostasis
.L-glutamate import
  + 38 more...
.diazepam binding
.beta-tubulin binding
.dynein intermediate chain binding
  + 6 more...
.protein complex
.cytoplasmic vesicle membrane
.dendrite
  + 11 more...
3 EBI-10187928,EBI-10175300 CCHCR1  
  .cell differentiation
.multicellular organismal development
.protein export from nucleus
.N/A .centriole
.cytoplasm
.nucleus
4 EBI-10187928,EBI-2691489 MITD1  
  .negative regulation of protein binding
.transport
.cell separation after cytokinesis
.mitotic cytokinesis
.protein homodimerization activity
.phosphatidylinositol binding
.protein domain specific binding
.extracellular exosome
.intracellular membrane-bounded organelle
.late endosome membrane
  + 2 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adrenal gland30
ascites75
blood73
bone69
bone marrow20
brain34
cervix103
connective tissue40
embryonic tissue23
esophagus49
eye67
heart11
intestine60
kidney52
liver14
lung65
lymph node33
mammary gland66
ovary88
pancreas18
placenta31
prostate52
salivary gland98
skin33
spleen37
stomach41
testis9
thymus12
thyroid42
tonsil58
trachea19
uterus60
vascular19
Health State
TissuesTPM*
normal28
breast (mammary gland) tumor85
cervical tumor28
chondrosarcoma60
colorectal tumor97
esophageal tumor57
gastrointestinal tumor59
germ cell tumor34
glioma83
head and neck tumor14
kidney tumor43
leukemia63
liver tumor10
lung tumor77
lymphoma69
non-neoplasia41
ovarian tumor78
pancreatic tumor38
primitive neuroectodermal tumor of the CNS31
prostate cancer67
retinoblastoma86
skin tumor31
soft tissue/muscle tissue tumor23
uterine tumor122
Developmental Stage
TissuesTPM*
adult47
embryoid body28
blastocyst32
fetus25
infant42
juvenile17
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue11.4
adrenal gland13
appendix15.3
bone marrow12
cerebral cortex11.3
colon15.2
duodenum23.6
esophagus19.8
gallbladder18.4
heart muscle11.7
kidney18.5
liver14.9
lung14.1
lymph node19.1
ovary20.8
pancreas6.6
placenta17.2
prostate15.3
salivary gland17.3
skin22.8
small intestine22.2
spleen15.5
stomach15.8
testis12.1
thyroid gland10.9
urinary bladder18.7
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected


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