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> Protein (NX_Q96K76)
Protein (NX_Q96K76)
Protein
Gene SymbolUSP47 to neXtProt (NX_Q96K76)
DescriptionUbiquitin carboxyl-terminal hydrolase 47
Chromosome11
Location11p15.3 (11862970 ~ 11980870) to Ensembl
Sequene Features : Isoforms 4, Variants 118, PTMs 10 to neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage
.regulation of proteasomal protein catabolic process
.negative regulation of transcription, DNA-templated
  + 10 more...
.WD40-repeat domain binding
.ubiquitin-specific protease activity
.cysteine-type endopeptidase activity
.SCF ubiquitin ligase complex
.cytoplasm
.nucleus
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
4 118 10
2014-09-19protein level
4 90 10
2014-05-27protein level
3 90 10
2014-02-25protein level
3 89 10
2013-12-09protein level
3 73 10
2013-11-01protein level
3 72 8
2013-09-12protein level
3 72 8
2013-08-17protein level
3 72 8
2013-07-15protein level
3 47 7
2013-06-11protein level
3 47 7
2013-02-12protein level
3 19 15
2012-12-20protein level
3 16 15
2012-10-30protein level
3 23 15
2012-10-07protein level
3 23 7
2012-08-24protein level
3 22 7
2012-07-28protein level
3 22 7
2012-06-08protein level
3 30 7
2012-05-07protein level
3 22 7
2012-04-10protein level
3 22 7
2012-01-13protein level
3 15 7
2011-12-20protein level
3 15 7
2011-11-11protein level
3 15 6
2011-08-23protein level
3 15 6
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q96K76-1
2 66 0 157212.0139
NX_Q96K76-2
1 62 0 147129.9253
NX_Q96K76-3
0 7 0 18138.1458
NX_Q96K76-4
1 66 0 154599.7068
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-2514143,EBI-3914106 AP4M1  
  .membrane organization
.vesicle-mediated transport
.Golgi to endosome transport
  + 2 more...
.transporter activity .extracellular exosome
.trans-Golgi network membrane
.endosome lumen
  + 5 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adrenal gland30
ascites50
bladder66
blood32
bone27
bone marrow20
brain53
cervix61
connective tissue60
ear186
embryonic tissue46
esophagus148
eye95
heart33
intestine43
kidney104
larynx42
liver53
lung77
lymph node66
mammary gland26
mouth120
muscle84
nerve128
ovary9
pancreas23
pharynx98
pituitary gland60
placenta67
prostate100
salivary gland49
skin52
spleen18
stomach41
testis41
thymus37
thyroid21
trachea135
umbilical cord145
uterus77
vascular135
Health State
TissuesTPM*
normal69
breast (mammary gland) tumor21
cervical tumor86
chondrosarcoma48
colorectal tumor26
esophageal tumor115
gastrointestinal tumor50
germ cell tumor56
glioma83
head and neck tumor44
kidney tumor130
leukemia31
liver tumor41
lung tumor9
lymphoma13
non-neoplasia51
pancreatic tumor9
primitive neuroectodermal tumor of the CNS15
prostate cancer57
retinoblastoma86
skin tumor15
soft tissue/muscle tissue tumor31
uterine tumor88
Developmental Stage
TissuesTPM*
adult49
embryoid body42
blastocyst32
neonate64
fetus93
infant42
juvenile53
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue24.7
adrenal gland29.4
appendix25.5
bone marrow39
cerebral cortex30.7
colon23.9
duodenum21.6
esophagus30.5
gallbladder27.7
heart muscle34.5
kidney23.4
liver27.1
lung26.9
lymph node29.3
ovary31.3
pancreas19.8
placenta34.4
prostate32.3
salivary gland19.6
skin34
small intestine22.7
spleen24
stomach28
testis33.6
thyroid gland30
urinary bladder29.9
Tissues
TissuesExpression level
adrenal glandMedium
appendixHigh
bone marrowLow
breastHigh
bronchusHigh
cerebellumMedium
cerebral cortexMedium
cervix, uterineHigh
colonHigh
duodenumHigh
endometrium 1Medium
endometrium 2Medium
epididymisMedium
esophagusMedium
fallopian tubeMedium
gallbladderHigh
heart muscleMedium
hippocampusLow
kidneyHigh
lateral ventricleLow
liverHigh
lungMedium
lymph nodeMedium
nasopharynxHigh
oral mucosaHigh
ovaryLow
pancreasMedium
parathyroid glandMedium
placentaMedium
prostateHigh
rectumHigh
salivary glandHigh
seminal vesicleMedium
skeletal muscleHigh
skin 1Medium
skin 2Medium
small intestineHigh
smooth muscleMedium
soft tissue 1Medium
soft tissue 2Medium
spleenLow
stomach 1High
stomach 2Medium
testisMedium
thyroid glandMedium
tonsilMedium
urinary bladderHigh
vaginaHigh
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*614460, gene) Ubiquitin-specific protease 47; USP47OMIM


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