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> Protein (NX_Q96KP6)
Protein (NX_Q96KP6)
Protein
Gene SymbolTNIP3 to neXtProt (NX_Q96KP6)
DescriptionTNFAIP3-interacting protein 3
Chromosome4
Location4q27 (122052563 ~ 122148621) to Ensembl
Sequene Features : Isoforms 3, Variants 64, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.cellular response to lipopolysaccharide
.negative regulation of I-kappaB kinase/NF-kappaB signaling
.toll-like receptor 4 signaling pathway
  + 2 more...
.polyubiquitin binding .N/A
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
3 64 0
2014-09-19protein level
3 49 0
2014-05-27protein level
3 49 0
2014-02-25protein level
3 49 0
2013-12-09protein level
3 39 0
2013-11-01protein level
3 35 0
2013-09-12protein level
3 35 0
2013-08-17protein level
3 35 0
2013-07-15protein level
3 19 0
2013-06-11protein level
3 19 0
2013-02-12protein level
3 11 0
2012-12-20protein level
1 8 0
2012-10-30protein level
1 13 0
2012-10-07protein level
1 13 0
2012-08-24protein level
1 11 0
2012-07-28protein level
1 10 0
2012-06-08protein level
1 12 0
2012-05-07protein level
1 12 0
2012-04-10protein level
1 12 0
2012-01-13protein level
1 6 0
2011-12-20protein level
1 6 0
2011-11-11protein level
1 6 0
2011-08-23protein level
1 6 0
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q96KP6-1
3 12 0 38918.437
NX_Q96KP6-2
0 16 0 44056.8358
NX_Q96KP6-3
1 16 0 44857.2051
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-2509913,EBI-527670 TNFAIP3  
  .negative regulation of endothelial cell apoptotic process
.negative regulation of CD40 signaling pathway
.positive regulation of hepatocyte proliferation
  + 46 more...
.protein self-association
.ubiquitin binding
.ligase activity
  + 5 more...
.extracellular exosome
.cytosol
.centrosome
  + 3 more...
2 EBI-2509913,EBI-10171774 KRTAP10-8  
  .N/A .N/A .keratin filament
3 EBI-2509913,EBI-357849 TNIP1  
  .modulation by symbiont of host I-kappaB kinase/NF-kappaB cascade
.negative regulation of ERK1 and ERK2 cascade
.positive regulation of inflammatory response
  + 9 more...
.mitogen-activated protein kinase binding .cytoplasm
.nucleus
.intracellular
4 EBI-2509913,EBI-724310 DAZAP2  
  .N/A .WW domain binding .cytoplasm
.nucleus
5 EBI-2509913,EBI-10171697 KRT40  
  .N/A .structural molecule activity .intermediate filament
6 EBI-2509913,EBI-945833 NOTCH2NL  
  .cell differentiation
.multicellular organismal development
.Notch signaling pathway
.calcium ion binding .cytoplasm
.extracellular region
7 EBI-2509913,EBI-529518 TAX1BP1  
  .innate immune response
.negative regulation of apoptotic process
.negative regulation of type I interferon production
  + 2 more...
.metal ion binding
.kinase binding
.extracellular exosome
.cytosol
8 EBI-2509913,EBI-742740 ZBTB8A  
  .regulation of transcription, DNA-templated
.transcription, DNA-templated
.metal ion binding
.DNA binding
.nucleus
9 EBI-2509913,EBI-741037 LZTS2  
  .negative regulation of protein localization to nucleus
.negative regulation of canonical Wnt signaling pathway
.spindle midzone assembly
  + 7 more...
.N/A .midbody
.microtubule
.centrosome
.cytoplasm
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
blood16
cervix20
connective tissue20
embryonic tissue4
eye9
lung11
mammary gland6
spleen18
testis4
thymus12
vascular58
Health State
TissuesTPM*
normal5
breast (mammary gland) tumor10
cervical tumor28
soft tissue/muscle tissue tumor23
Developmental Stage
TissuesTPM*
adult5
neonate32
fetus1
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
appendix7.3
cerebral cortex1.1
gallbladder1.1
lung1
lymph node2.4
urinary bladder1.2
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*608019, gene) Tnfaip3-interacting protein 3; TNIP3OMIM


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