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Protein |
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Gene Symbol | CNOT6L to neXtProt (NX_Q96LI5) |
Description | CCR4-NOT transcription complex subunit 6-like |
Chromosome | 4 |
Location | 4q21.1 (78634541 ~ 78740769) to Ensembl |
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Sequene Features : Isoforms 2, Variants 42, PTMs 0 to neXtProt Sequence Features
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Gene Ontologies |
GO: Biological Process |
GO: Mulecular Function |
GO: Cellular Component |
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.RNA phosphodiester bond hydrolysis, exonucleolytic .mRNA destabilization .gene silencing by RNA + 8 more... |
.metal ion binding .poly(A)-specific ribonuclease activity |
.CCR4-NOT complex .cytosol .cytoplasm .nucleus |
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Proteomic Evidences |
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Release | | Protein Evidence | | Pr | | Ab | | Isoforms | | Variants | | PTMs |
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2015-01-01 | | protein level | | | | | | | 2 |
| 42 |
| 0 |
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2014-09-19 | | protein level | | | | | | | 2 |
| 30 |
| 0 |
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2014-05-27 | | protein level | | | | | | | 2 |
| 30 |
| 0 |
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2014-02-25 | | protein level | | | | | | | 2 |
| 29 |
| 0 |
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2013-12-09 | | protein level | | | | | | | 2 |
| 24 |
| 0 |
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2013-11-01 | | protein level | | | | | | | 2 |
| 24 |
| 0 |
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2013-09-12 | | protein level | | | | | | | 2 |
| 24 |
| 0 |
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2013-08-17 | | protein level | | | | | | | 2 |
| 24 |
| 0 |
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2013-07-15 | | protein level | | | | | | | 2 |
| 16 |
| 0 |
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2013-06-11 | | protein level | | | | | | | 2 |
| 16 |
| 0 |
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2013-02-12 | | protein level | | | | | | | 2 |
| 6 |
| 0 |
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2012-12-20 | | protein level | | | | | | | 2 |
| 6 |
| 0 |
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2012-10-30 | | protein level | | | | | | | 2 |
| 5 |
| 0 |
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2012-10-07 | | protein level | | | | | | | 2 |
| 5 |
| 0 |
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2012-08-24 | | protein level | | | | | | | 2 |
| 0 |
| 0 |
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2012-07-28 | | protein level | | | | | | | 2 |
| 0 |
| 0 |
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2012-06-08 | | protein level | | | | | | | 2 |
| 7 |
| 0 |
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2012-05-07 | | protein level | | | | | | | 2 |
| 7 |
| 0 |
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2012-04-10 | | protein level | | | | | | | 2 |
| 7 |
| 0 |
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2012-01-13 | | protein level | | | | | | | 2 |
| 7 |
| 0 |
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2011-12-20 | | protein level | | | | | | | 2 |
| 7 |
| 0 |
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2011-11-11 | | protein level | | | | | | | 2 |
| 4 |
| 0 |
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2011-08-23 | | protein level | | | | | | | 2 |
| 4 |
| 0 |
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Protein Isoforms |
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| : Uniquely mapped peptide | | : Gene-specific peptide | | : Shared peptide |
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Interacting Partners |
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No. |
Exp. ref. |
Symbol |
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PE |
Pr |
Ab |
Di |
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GO: Biological Process |
GO: Mulecular Function |
GO: Cellular Component |
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1 |
EBI-1046635,EBI-1222758 |
CNOT1 |
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.regulation of stem cell maintenance .positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay .RNA phosphodiester bond hydrolysis, exonucleolytic + 13 more... |
.armadillo repeat domain binding .poly(A) RNA binding .retinoic acid receptor binding + 3 more... |
.CCR4-NOT complex .membrane .cytosol + 4 more... |
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2 |
EBI-1046635,EBI-743073 |
CNOT3 |
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.regulation of stem cell maintenance .gene silencing by RNA .gene expression + 6 more... |
.N/A |
.CCR4-NOT complex .cytosol .nucleus .cytoplasmic mRNA processing body |
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3 |
EBI-1046635,EBI-723281 |
TOB1 |
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.positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay .positive regulation of nuclear-transcribed mRNA poly(A) tail shortening .negative regulation of nuclear-transcribed mRNA poly(A) tail shortening + 6 more... |
.receptor tyrosine kinase binding .SH3/SH2 adaptor activity .transcription corepressor activity |
.CCR4-NOT complex .cytoplasm .nucleus |
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EST expression level of Protein Coding Gene (ref. NCBI UniGene EST) |
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Body Sites | |
Tissues | TPM* | |
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adipose tissue | 77 | |
adrenal gland | 182 | |
bladder | 100 | |
blood | 32 | |
bone | 13 | |
bone marrow | 20 | |
brain | 33 | |
cervix | 82 | |
connective tissue | 13 | |
ear | 124 | |
embryonic tissue | 32 | |
esophagus | 49 | |
eye | 38 | |
heart | 11 | |
intestine | 30 | |
kidney | 28 | |
liver | 14 | |
lung | 26 | |
lymph node | 133 | |
mammary gland | 66 | |
muscle | 47 | |
nerve | 128 | |
ovary | 19 | |
pancreas | 56 | |
pharynx | 24 | |
placenta | 67 | |
prostate | 15 | |
salivary gland | 49 | |
skin | 23 | |
spleen | 131 | |
stomach | 20 | |
testis | 34 | |
thymus | 87 | |
trachea | 173 | |
umbilical cord | 72 | |
uterus | 34 | |
vascular | 58 | |
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Health State | |
Tissues | TPM* | |
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normal | 44 | |
adrenal tumor | 474 | |
bladder carcinoma | 227 | |
breast (mammary gland) tumor | 85 | |
chondrosarcoma | 24 | |
colorectal tumor | 17 | |
esophageal tumor | 57 | |
germ cell tumor | 26 | |
glioma | 18 | |
kidney tumor | 29 | |
leukemia | 21 | |
liver tumor | 20 | |
lymphoma | 13 | |
non-neoplasia | 31 | |
ovarian tumor | 13 | |
pancreatic tumor | 19 | |
primitive neuroectodermal tumor of the CNS | 15 | |
prostate cancer | 19 | |
retinoblastoma | 21 | |
skin tumor | 23 | |
uterine tumor | 11 | |
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Developmental Stage | |
Tissues | TPM* | |
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adult | 39 | |
blastocyst | 16 | |
neonate | 32 | |
fetus | 59 | |
infant | 42 | |
juvenile | 17 | |
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TPM*: Transcripts per million; transcript expression level measured by expression sequence tags. |
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Expression level of Protein (ref. Human Protein Atlas) |
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RNA-Seq. | |
Tissues | FPKM | |
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adipose tissue | 6.8 | |
adrenal gland | 8.1 | |
appendix | 16.3 | |
bone marrow | 11.9 | |
cerebral cortex | 5.7 | |
colon | 9.4 | |
duodenum | 8.3 | |
esophagus | 9.9 | |
gallbladder | 10.1 | |
heart muscle | 3.7 | |
kidney | 9 | |
liver | 7.8 | |
lung | 7.4 | |
lymph node | 24.3 | |
ovary | 9.2 | |
pancreas | 5.4 | |
placenta | 14.8 | |
prostate | 8.1 | |
salivary gland | 6.6 | |
skin | 10 | |
small intestine | 9.8 | |
spleen | 15.4 | |
stomach | 10.7 | |
testis | 7.4 | |
thyroid gland | 9.7 | |
urinary bladder | 11.5 | |
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Cancer | |
Tumor | Number of patients and Staining levels | |
breast cancer | |
carcinoid | |
cervical cancer | |
colorectal cancer | |
endometrial cancer | |
glioma | |
head and neck cancer | |
liver cancer | |
lung cancer | |
lymphoma | |
melanoma | |
ovarian cancer | |
pancreatic cancer | |
prostate cancer | |
renal cancer | |
skin cancer | |
stomach cancer | |
testis cancer | |
thyroid cancer | |
urothelial cancer | |
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RNA-seq colour codes |
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Highly expressed RNAs (FPKM >50) |
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Moderately expressed RNAs (50> FPKM >10) |
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Lower expressed RNAs (10> FPKM >1) |
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The lowest expressed RNAs (FPKM value of 0 or 1) |
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Staining level colour codes |
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Highly expressed protein |
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Moderately expressed protein |
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Lower expressed protein |
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Not Detected |
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