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> Protein (NX_Q96LI5)
Protein (NX_Q96LI5)
Protein
Gene SymbolCNOT6L to neXtProt (NX_Q96LI5)
DescriptionCCR4-NOT transcription complex subunit 6-like
Chromosome4
Location4q21.1 (78634541 ~ 78740769) to Ensembl
Sequene Features : Isoforms 2, Variants 42, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.RNA phosphodiester bond hydrolysis, exonucleolytic
.mRNA destabilization
.gene silencing by RNA
  + 8 more...
.metal ion binding
.poly(A)-specific ribonuclease activity
.CCR4-NOT complex
.cytosol
.cytoplasm
.nucleus
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
2 42 0
2014-09-19protein level
2 30 0
2014-05-27protein level
2 30 0
2014-02-25protein level
2 29 0
2013-12-09protein level
2 24 0
2013-11-01protein level
2 24 0
2013-09-12protein level
2 24 0
2013-08-17protein level
2 24 0
2013-07-15protein level
2 16 0
2013-06-11protein level
2 16 0
2013-02-12protein level
2 6 0
2012-12-20protein level
2 6 0
2012-10-30protein level
2 5 0
2012-10-07protein level
2 5 0
2012-08-24protein level
2 0 0
2012-07-28protein level
2 0 0
2012-06-08protein level
2 7 0
2012-05-07protein level
2 7 0
2012-04-10protein level
2 7 0
2012-01-13protein level
2 7 0
2011-12-20protein level
2 7 0
2011-11-11protein level
2 4 0
2011-08-23protein level
2 4 0
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q96LI5-1
4 18 4 62960.8462
NX_Q96LI5-2
2 18 3 53856.0066
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-1046635,EBI-1222758 CNOT1  
  .regulation of stem cell maintenance
.positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
.RNA phosphodiester bond hydrolysis, exonucleolytic
  + 13 more...
.armadillo repeat domain binding
.poly(A) RNA binding
.retinoic acid receptor binding
  + 3 more...
.CCR4-NOT complex
.membrane
.cytosol
  + 4 more...
2 EBI-1046635,EBI-743073 CNOT3  
  .regulation of stem cell maintenance
.gene silencing by RNA
.gene expression
  + 6 more...
.N/A .CCR4-NOT complex
.cytosol
.nucleus
.cytoplasmic mRNA processing body
3 EBI-1046635,EBI-723281 TOB1  
  .positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
.positive regulation of nuclear-transcribed mRNA poly(A) tail shortening
.negative regulation of nuclear-transcribed mRNA poly(A) tail shortening
  + 6 more...
.receptor tyrosine kinase binding
.SH3/SH2 adaptor activity
.transcription corepressor activity
.CCR4-NOT complex
.cytoplasm
.nucleus
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue77
adrenal gland182
bladder100
blood32
bone13
bone marrow20
brain33
cervix82
connective tissue13
ear124
embryonic tissue32
esophagus49
eye38
heart11
intestine30
kidney28
liver14
lung26
lymph node133
mammary gland66
muscle47
nerve128
ovary19
pancreas56
pharynx24
placenta67
prostate15
salivary gland49
skin23
spleen131
stomach20
testis34
thymus87
trachea173
umbilical cord72
uterus34
vascular58
Health State
TissuesTPM*
normal44
adrenal tumor474
bladder carcinoma227
breast (mammary gland) tumor85
chondrosarcoma24
colorectal tumor17
esophageal tumor57
germ cell tumor26
glioma18
kidney tumor29
leukemia21
liver tumor20
lymphoma13
non-neoplasia31
ovarian tumor13
pancreatic tumor19
primitive neuroectodermal tumor of the CNS15
prostate cancer19
retinoblastoma21
skin tumor23
uterine tumor11
Developmental Stage
TissuesTPM*
adult39
blastocyst16
neonate32
fetus59
infant42
juvenile17
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue6.8
adrenal gland8.1
appendix16.3
bone marrow11.9
cerebral cortex5.7
colon9.4
duodenum8.3
esophagus9.9
gallbladder10.1
heart muscle3.7
kidney9
liver7.8
lung7.4
lymph node24.3
ovary9.2
pancreas5.4
placenta14.8
prostate8.1
salivary gland6.6
skin10
small intestine9.8
spleen15.4
stomach10.7
testis7.4
thyroid gland9.7
urinary bladder11.5
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected


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