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	> Protein (NX_Q96LI5) Protein (NX_Q96LI5) Protein Gene Symbol CNOT6L to neXtProt (NX_Q96LI5) Description CCR4-NOT transcription complex subunit 6-like Chromosome 4 Location 4q21.1 (78634541 ~ 78740769) to Ensembl Sequene Features : Isoforms 2, Variants 42, PTMs 0 to neXtProt Sequence Features Gene Ontologies GO: Biological Process GO: Mulecular Function GO: Cellular Component .RNA phosphodiester bond hydrolysis, exonucleolytic .mRNA destabilization .gene silencing by RNA   + 8 more... .metal ion binding .poly(A)-specific ribonuclease activity .CCR4-NOT complex .cytosol .cytoplasm .nucleus Proteomic Evidences Release Protein Evidence Pr Ab Isoforms Variants PTMs 2015-01-01 protein level 2 42 0 2014-09-19 protein level 2 30 0 2014-05-27 protein level 2 30 0 2014-02-25 protein level 2 29 0 2013-12-09 protein level 2 24 0 2013-11-01 protein level 2 24 0 2013-09-12 protein level 2 24 0 2013-08-17 protein level 2 24 0 2013-07-15 protein level 2 16 0 2013-06-11 protein level 2 16 0 2013-02-12 protein level 2 6 0 2012-12-20 protein level 2 6 0 2012-10-30 protein level 2 5 0 2012-10-07 protein level 2 5 0 2012-08-24 protein level 2 0 0 2012-07-28 protein level 2 0 0 2012-06-08 protein level 2 7 0 2012-05-07 protein level 2 7 0 2012-04-10 protein level 2 7 0 2012-01-13 protein level 2 7 0 2011-12-20 protein level 2 7 0 2011-11-11 protein level 2 4 0 2011-08-23 protein level 2 4 0 Protein Isoforms Isoform Ac   U G S Mw (Da) NX_Q96LI5-1 4 18 4 62960.8462 NX_Q96LI5-2 2 18 3 53856.0066 : Uniquely mapped peptide : Gene-specific peptide : Shared peptide Interacting Partners No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component 1 EBI-1046635,EBI-1222758 CNOT1     .regulation of stem cell maintenance .positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay .RNA phosphodiester bond hydrolysis, exonucleolytic   + 13 more... .armadillo repeat domain binding .poly(A) RNA binding .retinoic acid receptor binding   + 3 more... .CCR4-NOT complex .membrane .cytosol   + 4 more... 2 EBI-1046635,EBI-743073 CNOT3     .regulation of stem cell maintenance .gene silencing by RNA .gene expression   + 6 more... .N/A .CCR4-NOT complex .cytosol .nucleus .cytoplasmic mRNA processing body 3 EBI-1046635,EBI-723281 TOB1     .positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay .positive regulation of nuclear-transcribed mRNA poly(A) tail shortening .negative regulation of nuclear-transcribed mRNA poly(A) tail shortening   + 6 more... .receptor tyrosine kinase binding .SH3/SH2 adaptor activity .transcription corepressor activity .CCR4-NOT complex .cytoplasm .nucleus EST expression level of Protein Coding Gene (ref. NCBI UniGene EST) Body Sites Tissues TPM* adipose tissue 77 adrenal gland 182 bladder 100 blood 32 bone 13 bone marrow 20 brain 33 cervix 82 connective tissue 13 ear 124 embryonic tissue 32 esophagus 49 eye 38 heart 11 intestine 30 kidney 28 liver 14 lung 26 lymph node 133 mammary gland 66 muscle 47 nerve 128 ovary 19 pancreas 56 pharynx 24 placenta 67 prostate 15 salivary gland 49 skin 23 spleen 131 stomach 20 testis 34 thymus 87 trachea 173 umbilical cord 72 uterus 34 vascular 58 Health State Tissues TPM* normal 44 adrenal tumor 474 bladder carcinoma 227 breast (mammary gland) tumor 85 chondrosarcoma 24 colorectal tumor 17 esophageal tumor 57 germ cell tumor 26 glioma 18 kidney tumor 29 leukemia 21 liver tumor 20 lymphoma 13 non-neoplasia 31 ovarian tumor 13 pancreatic tumor 19 primitive neuroectodermal tumor of the CNS 15 prostate cancer 19 retinoblastoma 21 skin tumor 23 uterine tumor 11 Developmental Stage Tissues TPM* adult 39 blastocyst 16 neonate 32 fetus 59 infant 42 juvenile 17 TPM*: Transcripts per million; transcript expression level measured by expression sequence tags. Expression level of Protein (ref. Human Protein Atlas) RNA-Seq. Tissues FPKM adipose tissue 6.8 adrenal gland 8.1 appendix 16.3 bone marrow 11.9 cerebral cortex 5.7 colon 9.4 duodenum 8.3 esophagus 9.9 gallbladder 10.1 heart muscle 3.7 kidney 9 liver 7.8 lung 7.4 lymph node 24.3 ovary 9.2 pancreas 5.4 placenta 14.8 prostate 8.1 salivary gland 6.6 skin 10 small intestine 9.8 spleen 15.4 stomach 10.7 testis 7.4 thyroid gland 9.7 urinary bladder 11.5 Cancer Tumor Number of patients and Staining levels breast cancer carcinoid cervical cancer colorectal cancer endometrial cancer glioma head and neck cancer liver cancer lung cancer lymphoma melanoma ovarian cancer pancreatic cancer prostate cancer renal cancer skin cancer stomach cancer testis cancer thyroid cancer urothelial cancer RNA-seq colour codes Highly expressed RNAs (FPKM >50) Moderately expressed RNAs (50> FPKM >10) Lower expressed RNAs (10> FPKM >1) The lowest expressed RNAs (FPKM value of 0 or 1) Staining level colour codes Highly expressed protein Moderately expressed protein Lower expressed protein Not Detected

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