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> Protein (NX_Q96LR5)
Protein (NX_Q96LR5)
Protein
Gene SymbolUBE2E2 to neXtProt (NX_Q96LR5)
DescriptionUbiquitin-conjugating enzyme E2 E2
Chromosome3
Location3p24.3 (23244511 ~ 23633284) to Ensembl
Sequene Features : Isoforms 1, Variants 22, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.positive regulation of G1/S transition of mitotic cell cycle
.protein K11-linked ubiquitination
.protein K48-linked ubiquitination
  + 3 more...
.ubiquitin conjugating enzyme activity
.ISG15 transferase activity
.ligase activity
  + 2 more...
.N/A
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
1 22 2
2014-09-19protein level
1 18 2
2014-05-27protein level
1 18 4
2014-02-25protein level
1 18 4
2013-12-09protein level
1 17 4
2013-11-01protein level
1 15 4
2013-09-12protein level
1 15 4
2013-08-17protein level
1 15 4
2013-07-15protein level
1 7 2
2013-06-11protein level
1 7 2
2013-02-12protein level
1 2 2
2012-12-20protein level
1 2 2
2012-10-30protein level
1 2 2
2012-10-07protein level
1 2 2
2012-08-24protein level
1 2 2
2012-07-28protein level
1 2 2
2012-06-08protein level
1 2 2
2012-05-07protein level
1 3 2
2012-04-10protein level
1 3 2
2012-01-13protein level
1 2 2
2011-12-20protein level
1 2 2
2011-11-11protein level
1 2 1
2011-08-23protein level
1 2 1
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q96LR5-1
3 0 5 22241.0757
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-2129763,EBI-2340316 MID1  
  .interferon-gamma-mediated signaling pathway
.protein localization to microtubule
.positive regulation of stress-activated MAPK cascade
  + 4 more...
.phosphoprotein binding
.protein heterodimerization activity
.protein homodimerization activity
  + 5 more...
.microtubule associated complex
.microtubule
.cytosol
.spindle
2 EBI-2129763,EBI-724310 DAZAP2  
  .N/A .WW domain binding .cytoplasm
.nucleus
3 EBI-2129763,EBI-10175124 FAM9B  
  .spermatid development .N/A .nucleoplasm
4 EBI-2129763,EBI-2875665 ARRDC3  
  .negative regulation of locomotion involved in locomotory behavior
.positive regulation of adrenergic receptor signaling pathway
.fat pad development
  + 5 more...
.beta-3 adrenergic receptor binding .plasma membrane
.endosome
5 EBI-2129763,EBI-348482 RNF5  
  .regulation of autophagic vacuole assembly
.ER-associated misfolded protein catabolic process
.protein K48-linked ubiquitination
  + 5 more...
.ligase activity
.zinc ion binding
.ubiquitin-protein transferase activity
.mitochondrial membrane
.integral component of membrane
.endoplasmic reticulum membrane
6 EBI-2129763,EBI-739510 TRIM39  
  .positive regulation of apoptotic signaling pathway
.negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process
.protein ubiquitination
.apoptotic process
.identical protein binding
.ligase activity
.zinc ion binding
.cytosol
.mitochondrion
7 EBI-2129763,EBI-10172526 MID2  
  .negative regulation of viral release from host cell
.positive regulation of NF-kappaB transcription factor activity
.positive regulation of sequence-specific DNA binding transcription factor activity
  + 6 more...
.phosphoprotein binding
.protein heterodimerization activity
.protein homodimerization activity
  + 3 more...
.extracellular exosome
.microtubule
.cytoplasm
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
blood32
bone27
bone marrow20
brain55
connective tissue160
ear62
embryonic tissue28
eye33
intestine8
kidney28
liver4
lung32
lymph node22
mammary gland13
ovary19
pancreas9
pharynx24
pituitary gland60
prostate10
testis22
uterus4
vascular19
Health State
TissuesTPM*
normal4
chondrosarcoma48
germ cell tumor34
glioma55
head and neck tumor7
lymphoma13
ovarian tumor26
pancreatic tumor9
Developmental Stage
TissuesTPM*
adult5
embryoid body14
fetus8
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue31
adrenal gland17
appendix20.6
bone marrow5
cerebral cortex42.9
colon11.2
duodenum9.2
esophagus37.8
gallbladder40.4
heart muscle40.8
kidney29.4
liver14.3
lung28.4
lymph node35
ovary31.5
pancreas7.8
placenta17.3
prostate28.8
salivary gland13.4
skin23.2
small intestine6.7
spleen25.8
stomach8.1
testis36.9
thyroid gland42.1
urinary bladder41.5
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*602163, gene) Ubiquitin-conjugating enzyme e2e 2; UBE2E2OMIM


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