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> Protein (NX_Q96M91)
Protein (NX_Q96M91)
Protein
Gene SymbolCFAP53 to neXtProt (NX_Q96M91)
DescriptionCilia- and flagella-associated protein 53
Chromosome18
Location18q21.1 (47753563 ~ 47792892) to Ensembl
Sequene Features : Isoforms 1, Variants 83, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.N/A .N/A .cilium
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
1 83 0
2014-09-19protein level
1 60 0
2014-05-27protein level
1 60 0
2014-02-25protein level
1 59 0
2013-12-09protein level
1 43 0
2013-11-01protein level
1 43 0
2013-09-12protein level
1 43 0
2013-08-17protein level
1 43 0
2013-07-15protein level
1 28 0
2013-06-11protein level
1 28 0
2013-02-12protein level
1 10 0
2012-12-20protein level
1 6 0
2012-10-30protein level
1 14 0
2012-10-07transcript level
1 14 0
2012-08-24transcript level
1 13 0
2012-07-28transcript level
1 13 0
2012-06-08transcript level
1 13 0
2012-05-07transcript level
1 13 0
2012-04-10transcript level
1 13 0
2012-01-13transcript level
1 8 0
2011-12-20transcript level
1 8 0
2011-11-11transcript level
1 8 0
2011-08-23transcript level
1 8 0
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q96M91-1
18 0 0 61796.142
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-742422,EBI-740098 TRIM23  
  .positive regulation of catalytic activity
.protein ubiquitination
.viral process
.small GTPase mediated signal transduction
.identical protein binding
.GDP binding
.ligase activity
  + 5 more...
.extracellular exosome
.lysosomal membrane
.nucleus
.Golgi membrane
2 EBI-742422,EBI-357849 TNIP1  
  .modulation by symbiont of host I-kappaB kinase/NF-kappaB cascade
.negative regulation of ERK1 and ERK2 cascade
.positive regulation of inflammatory response
  + 9 more...
.mitogen-activated protein kinase binding .cytoplasm
.nucleus
.intracellular
3 EBI-742422,EBI-302345 PNMA1  
  .positive regulation of apoptotic process
.inflammatory response to antigenic stimulus
.N/A .focal adhesion
.cytoplasm
.nucleolus
4 EBI-742422,EBI-739624 CEP70  
  .organelle organization
.mitotic cell cycle
.G2/M transition of mitotic cell cycle
.N/A .nuclear membrane
.cytosol
.centrosome
  + 2 more...
5 EBI-742422,EBI-740641 HMG20A  
  .negative regulation of neuron differentiation
.regulation of transcription, DNA-templated
.transcription, DNA-templated
  + 3 more...
.sequence-specific DNA binding transcription factor activity
.chromatin binding
.DNA binding
.nucleus
6 EBI-742422,EBI-947308 CBY1  
  .cardiac muscle cell differentiation
.negative regulation of transcription, DNA-templated
.fat cell differentiation
  + 2 more...
.identical protein binding
.beta-catenin binding
.nuclear speck
.cytosol
.trans-Golgi network
  + 2 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
brain2
eye4
kidney14
lung8
testis34
uterus8
Health State
TissuesTPM*
normal6
glioma18
kidney tumor14
uterine tumor22
Developmental Stage
TissuesTPM*
adult3
fetus5
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
kidney1.7
lung3.7
testis62.5
thyroid gland2.8
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*614759, gene) Coiled-coil domain-containing protein 11; CCDC11OMIM
2(#614779, phenotype) Heterotaxy, visceral, 6, autosomal; HTX6OMIM


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