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> Protein (NX_Q96MN9)
Protein (NX_Q96MN9)
Protein
Gene SymbolZNF488 to neXtProt (NX_Q96MN9)
DescriptionZinc finger protein 488
Chromosome10
Location10q11.22 (48355024 ~ 48373866) to Ensembl
Sequene Features : Isoforms 2, Variants 78, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.positive regulation of oligodendrocyte differentiation
.negative regulation of transcription, DNA-templated
.oligodendrocyte development
  + 2 more...
.metal ion binding
.DNA binding
.sequence-specific DNA binding RNA polymerase II transcription factor activity
.nucleus
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
2 78 0
2014-09-19protein level
1 58 0
2014-05-27protein level
1 58 0
2014-02-25protein level
1 57 0
2013-12-09protein level
1 39 0
2013-11-01protein level
1 37 0
2013-09-12protein level
1 37 0
2013-08-17protein level
1 37 0
2013-07-15protein level
1 27 0
2013-06-11protein level
1 27 0
2013-02-12protein level
1 17 0
2012-12-20protein level
1 17 0
2012-10-30protein level
1 17 0
2012-10-07protein level
1 17 0
2012-08-24protein level
1 17 0
2012-07-28protein level
1 17 0
2012-06-08protein level
1 17 0
2012-05-07protein level
1 14 0
2012-04-10protein level
1 14 0
2012-01-13protein level
1 10 0
2011-12-20protein level
1 10 0
2011-11-11protein level
1 10 0
2011-08-23transcript level
1 10 0
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q96MN9-1
7 9 0 36938.735
NX_Q96MN9-2
0 9 0 25653.7149
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-948288,EBI-7875264 DAB1  
  .lateral motor column neuron migration
.Golgi localization
.negative regulation of axonogenesis
  + 15 more...
.N/A .perinuclear region of cytoplasm
.apical part of cell
.neuronal cell body
  + 5 more...
2 EBI-948288,EBI-930964 ATXN1  
  .regulation of excitatory postsynaptic membrane potential
.nuclear export
.lung alveolus development
  + 9 more...
.protein self-association
.identical protein binding
.poly(G) binding
  + 4 more...
.intracellular membrane-bounded organelle
.nuclear inclusion body
.nuclear matrix
  + 3 more...
3 EBI-948288,EBI-10172814 PRR20C  
  .N/A .N/A .N/A
4 EBI-948288,EBI-618309 GOLGA2  
  .negative regulation of protein binding
.mitotic cell cycle
.syntaxin binding
.protein kinase binding
.Golgi cisterna membrane
.ER to Golgi transport vesicle
.cis-Golgi network
  + 4 more...
5 EBI-948288,EBI-355744 TRAF2  
  .positive regulation of extrinsic apoptotic signaling pathway
.regulation of extrinsic apoptotic signaling pathway via death domain receptors
.negative regulation of neuron death
  + 35 more...
.sphingolipid binding
.identical protein binding
.thioesterase binding
  + 10 more...
.IRE1-TRAF2-ASK1 complex
.TRAF2-GSTP1 complex
.membrane raft
  + 7 more...
6 EBI-948288,EBI-10171697 KRT40  
  .N/A .structural molecule activity .intermediate filament
7 EBI-948288,EBI-744695 BANP  
  .negative regulation of protein catabolic process
.protein localization to nucleus
.chromatin modification
  + 4 more...
.DNA binding .nucleoplasm
8 EBI-948288,EBI-740322 RBPMS  
  .positive regulation of SMAD protein import into nucleus
.positive regulation of pathway-restricted SMAD protein phosphorylation
.RNA processing
  + 2 more...
.poly(A) RNA binding
.poly(A) binding
.transcription coactivator activity
.nucleotide binding
.cytoplasm
.nucleoplasm
9 EBI-948288,EBI-10182375 RIMBP3  
  .N/A .N/A .N/A
10 EBI-948288,EBI-716006 MAGED1  
  .positive regulation of apoptotic signaling pathway
.extrinsic apoptotic signaling pathway in absence of ligand
.extrinsic apoptotic signaling pathway
  + 15 more...
.transcription coactivator activity .protein complex
.plasma membrane
.cytoplasm
  + 2 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
brain122
embryonic tissue4
eye28
intestine8
kidney14
lung8
mouth15
muscle37
pancreas14
placenta3
stomach20
testis2
thymus12
trachea38
uterus4
Health State
TissuesTPM*
normal39
colorectal tumor8
gastrointestinal tumor16
glioma111
head and neck tumor7
kidney tumor43
lung tumor9
non-neoplasia51
pancreatic tumor28
retinoblastoma43
soft tissue/muscle tissue tumor7
uterine tumor11
Developmental Stage
TissuesTPM*
adult11
blastocyst16
fetus12
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
cerebral cortex10.7
duodenum21.3
esophagus1
kidney1.2
placenta3.6
skin1.5
small intestine10.3
testis1.1
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected


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