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> Protein (NX_Q96MT8)
Protein (NX_Q96MT8)
Protein
Gene SymbolCEP63 to neXtProt (NX_Q96MT8)
DescriptionCentrosomal protein of 63 kDa
Chromosome3
Location3q22.2 (134204585 ~ 134293859) to Ensembl
Sequene Features : Isoforms 4, Variants 97, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.cell division
.spindle assembly
.signal transduction in response to DNA damage
  + 6 more...
.N/A .cytosol
.centriole
.centrosome
.spindle pole
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
4 97 3
2014-09-19protein level
4 77 3
2014-05-27protein level
4 77 3
2014-02-25protein level
4 76 3
2013-12-09protein level
4 55 3
2013-11-01protein level
4 55 3
2013-09-12protein level
4 55 2
2013-08-17protein level
4 55 2
2013-07-15protein level
4 36 1
2013-06-11protein level
4 36 1
2013-02-12protein level
4 25 0
2012-12-20protein level
4 27 0
2012-10-30protein level
4 30 0
2012-10-07protein level
4 30 0
2012-08-24protein level
4 27 0
2012-07-28protein level
4 26 0
2012-06-08protein level
4 27 0
2012-05-07protein level
4 23 0
2012-04-10protein level
4 23 0
2012-01-13protein level
4 8 0
2011-12-20protein level
4 8 0
2011-11-11protein level
4 8 0
2011-08-23protein level
4 8 0
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q96MT8-1
10 27 0 81292.9596
NX_Q96MT8-2
0 28 0 62975.1318
NX_Q96MT8-3
0 27 0 57871.673
NX_Q96MT8-4
2 24 0 55555.5603
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-741977,EBI-740402 DTNB  
  .N/A .zinc ion binding .synapse
.cytoplasm
2 EBI-741977,EBI-79934 ALOX5  
  .lipoxin metabolic process
.small molecule metabolic process
.lipoxygenase pathway
  + 4 more...
.iron ion binding
.arachidonate 5-lipoxygenase activity
.nuclear membrane
.nuclear matrix
.cytosol
  + 3 more...
3 EBI-741977,EBI-359793 TXLNA  
  .activation of mitophagy in response to mitochondrial depolarization
.B cell activation
.cell proliferation
.exocytosis
.high molecular weight B cell growth factor receptor binding
.cytokine activity
.membrane
.cytoplasm
.extracellular region
4 EBI-741977,EBI-638194 ARFIP2  
  .regulation of Arp2/3 complex-mediated actin nucleation
.ruffle organization
.actin cytoskeleton organization
  + 3 more...
.phosphatidylinositol-4-phosphate binding
.Rac GTPase binding
.GTP-dependent protein binding
.GTP binding
.trans-Golgi network membrane
.cell cortex
.plasma membrane
  + 2 more...
5 EBI-741977,EBI-530054 EZH2  
  .negative regulation of G1/S transition of mitotic cell cycle
.positive regulation of protein serine/threonine kinase activity
.protein localization to chromatin
  + 25 more...
.histone methyltransferase activity (H3-K27 specific)
.sequence-specific DNA binding
.histone methyltransferase activity
  + 7 more...
.pronucleus
.ESC/E(Z) complex
.cytoplasm
  + 3 more...
6 EBI-741977,EBI-719941 FAM161A  
  .response to stimulus
.cilium assembly
.visual perception
.N/A .ciliary basal body
.photoreceptor connecting cilium
.centrosome
.cytoplasm
7 EBI-741977,EBI-308614 CEP57  
  .protein homooligomerization
.microtubule anchoring
.fibroblast growth factor receptor signaling pathway
  + 5 more...
.protein homodimerization activity
.fibroblast growth factor binding
.microtubule cytoskeleton
.microtubule
.cytosol
  + 5 more...
8 EBI-741977,EBI-948630 DZIP3  
  .protein polyubiquitination .poly(A) RNA binding
.polyubiquitin binding
.phosphatase binding
  + 4 more...
.cytoplasm
9 EBI-741977,EBI-1104570 CEP57L1  
  .microtubule anchoring .N/A .microtubule
.microtubule organizing center
.cytoplasm
10 EBI-741977,EBI-597063 ZCCHC10  
  .N/A .zinc ion binding
.nucleic acid binding
.N/A
11 EBI-741977,EBI-1048247 TBC1D15  
  .positive regulation of GTPase activity
.regulation of GTPase activity
.GTPase activator activity .extracellular exosome
.mitochondrion
.cytoplasm
12 EBI-741977,EBI-10244131 FBF1  
  .establishment of epithelial cell polarity
.apical junction assembly
.cilium assembly
.organelle organization
.N/A .ciliary transition fiber
.cell junction
.cytosol
  + 3 more...
13 EBI-741977,EBI-356349 TANK  
  .innate immune response
.TRIF-dependent toll-like receptor signaling pathway
.toll-like receptor 4 signaling pathway
  + 5 more...
.metal ion binding
.ubiquitin protein ligase binding
.cytosol
.cytoplasm
14 EBI-741977,EBI-455078 SMARCE1  
  .negative regulation of transcription, DNA-templated
.ATP-dependent chromatin remodeling
.metabolic process
  + 4 more...
.protein N-terminus binding
.ligand-dependent nuclear receptor binding
.N-acetyltransferase activity
  + 4 more...
.nBAF complex
.npBAF complex
.protein complex
  + 6 more...
15 EBI-741977,EBI-2514791 HAUS1  
  .cell division
.centrosome organization
.spindle assembly
.mitotic nuclear division
.N/A .HAUS complex
.microtubule
.centrosome
  + 2 more...
16 EBI-741977,EBI-10295431 SSX3  
  .regulation of transcription, DNA-templated
.transcription, DNA-templated
.nucleic acid binding .nucleus
17 EBI-741977,EBI-745392 SYT17  
  .positive regulation of dendrite extension
.calcium ion-dependent exocytosis of neurotransmitter
.regulation of calcium ion-dependent exocytosis
  + 2 more...
.clathrin binding
.syntaxin binding
.calcium-dependent phospholipid binding
.calcium ion binding
.plasma membrane
.trans-Golgi network
18 EBI-741977,EBI-752122 NXT2  
  .mRNA transport
.protein transport
.N/A .cytoplasm
.nucleus
19 EBI-741977,EBI-529989 DISC1  
  .positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process
.regulation of synapse maturation
.canonical Wnt signaling pathway
  + 10 more...
.N/A .postsynaptic membrane
.ciliary basal body
.cell junction
  + 4 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adrenal gland60
ascites50
bladder33
blood81
bone69
bone marrow41
brain16
cervix82
connective tissue67
embryonic tissue51
esophagus148
eye19
heart11
intestine17
kidney42
larynx85
liver34
lung35
lymph67
mammary gland39
muscle37
ovary19
pancreas28
parathyroid97
placenta52
prostate42
salivary gland98
skin28
spleen37
stomach31
testis45
thymus87
thyroid128
trachea57
uterus21
vascular19
Health State
TissuesTPM*
normal39
adrenal tumor79
breast (mammary gland) tumor42
cervical tumor86
chondrosarcoma84
esophageal tumor173
gastrointestinal tumor33
germ cell tumor30
head and neck tumor52
kidney tumor58
leukemia84
liver tumor20
lung tumor19
lymphoma96
non-neoplasia31
ovarian tumor26
pancreatic tumor19
prostate cancer9
skin tumor23
soft tissue/muscle tissue tumor95
Developmental Stage
TissuesTPM*
adult43
embryoid body28
blastocyst48
fetus48
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue23.7
adrenal gland17.8
appendix15.6
bone marrow20.3
cerebral cortex13.3
colon14.7
duodenum10
esophagus13.4
gallbladder12.8
heart muscle19.8
kidney15.1
liver14.1
lung13.3
lymph node18
ovary16.5
pancreas7.8
placenta13.9
prostate17.1
salivary gland13.1
skin12.8
small intestine11.3
spleen16
stomach17.5
testis42.5
thyroid gland18.9
urinary bladder16.4
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*614724, gene) Centrosomal protein, 63-kd; CEP63OMIM
2(#614728, phenotype) Seckel syndrome 6; SCKL6OMIM


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