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> Protein (NX_Q96NY9)
Protein (NX_Q96NY9)
Protein
Gene SymbolMUS81 to neXtProt (NX_Q96NY9)
DescriptionCrossover junction endonuclease MUS81
Chromosome11
Location11q13.1 (65624597 ~ 65635124) to Ensembl
Sequene Features : Isoforms 1, Variants 62, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.response to intra-S DNA damage checkpoint signaling
.DNA recombination
.DNA repair
.DNA catabolic process, endonucleolytic
.3'-flap endonuclease activity
.metal ion binding
.DNA binding
.nucleolus
.nucleus
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
1 62 2
2014-09-19protein level
1 53 2
2014-05-27protein level
1 53 2
2014-02-25protein level
1 53 2
2013-12-09protein level
1 41 2
2013-11-01protein level
1 39 2
2013-09-12protein level
1 39 2
2013-08-17protein level
1 39 2
2013-07-15protein level
1 27 2
2013-06-11protein level
1 27 2
2013-02-12protein level
1 15 1
2012-12-20protein level
1 14 1
2012-10-30protein level
1 16 1
2012-10-07protein level
1 16 1
2012-08-24protein level
1 16 1
2012-07-28protein level
1 16 1
2012-06-08protein level
1 20 1
2012-05-07protein level
1 18 1
2012-04-10protein level
1 18 1
2012-01-13protein level
1 15 1
2011-12-20protein level
1 15 1
2011-11-11protein level
1 15 1
2011-08-23protein level
1 15 1
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q96NY9-1
25 0 0 61134.896
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-2370806,EBI-707816 FEN1  
  .RNA phosphodiester bond hydrolysis, endonucleolytic
.nucleic acid phosphodiester bond hydrolysis
.DNA replication, removal of RNA primer
  + 11 more...
.manganese ion binding
.5'-flap endonuclease activity
.5'-3' exonuclease activity
  + 8 more...
.membrane
.plasma membrane
.mitochondrion
  + 3 more...
2 EBI-2370806,EBI-2370740 SLX4  
  .response to intra-S DNA damage checkpoint signaling
.positive regulation of catalytic activity
.DNA double-strand break processing involved in repair via single-strand annealing
  + 4 more...
.5'-flap endonuclease activity
.enzyme activator activity
.Slx1-Slx4 complex
.cell junction
.cytoplasm
.nucleoplasm
3 EBI-2370806,EBI-2370825 EME1  
  .response to intra-S DNA damage checkpoint signaling
.DNA recombination
.DNA repair
.metal ion binding
.endonuclease activity
.DNA binding
.cytoplasm
.nucleolus
.nuclear heterochromatin
.nucleus
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue77
adrenal gland121
ascites75
bladder33
blood24
bone83
bone marrow102
brain80
cervix82
connective tissue80
ear124
embryonic tissue51
esophagus49
eye9
heart67
intestine51
kidney66
liver29
lung38
lymph90
lymph node178
mammary gland46
mouth105
nerve64
ovary39
pancreas23
pituitary gland60
placenta21
prostate15
salivary gland148
skin42
spleen37
stomach31
testis39
thymus125
trachea38
uterus64
vascular174
Health State
TissuesTPM*
normal51
breast (mammary gland) tumor64
cervical tumor57
chondrosarcoma72
colorectal tumor62
esophageal tumor57
gastrointestinal tumor59
germ cell tumor49
glioma130
head and neck tumor74
kidney tumor58
leukemia84
liver tumor52
lung tumor19
lymphoma152
non-neoplasia93
ovarian tumor39
pancreatic tumor38
primitive neuroectodermal tumor of the CNS86
skin tumor7
soft tissue/muscle tissue tumor7
uterine tumor33
Developmental Stage
TissuesTPM*
adult39
embryoid body71
blastocyst48
fetus82
infant42
juvenile53
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue21.7
adrenal gland21
appendix32.5
bone marrow17.3
cerebral cortex18.1
colon26.7
duodenum40.5
esophagus19.1
gallbladder24.6
heart muscle22.9
kidney18.2
liver9.7
lung31
lymph node46.1
ovary26.7
pancreas12.3
placenta23.6
prostate26
salivary gland19.7
skin23.1
small intestine30.2
spleen40.8
stomach26.3
testis21.8
thyroid gland23.1
urinary bladder26.4
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*606591, gene) Mus81, s. cerevisiae, homolog of; MUS81OMIM


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