Home| Contact Us

HOME SEARCH STATISTICS
> Protein (NX_Q96PM5)
Protein (NX_Q96PM5)
Protein
Gene SymbolRCHY1 to neXtProt (NX_Q96PM5)
DescriptionRING finger and CHY zinc finger domain-containing protein 1
Chromosome4
Location4q21.1 (76404247 ~ 76439974) to Ensembl
Sequene Features : Isoforms 8, Variants 22, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.error-free translesion synthesis
.protein autoubiquitination
.protein ubiquitination involved in ubiquitin-dependent protein catabolic process
  + 5 more...
.protein homodimerization activity
.ligase activity
.zinc ion binding
  + 2 more...
.nuclear speck
.cytoplasm
.nucleoplasm
  + 2 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
8 22 2
2014-09-19protein level
8 18 2
2014-05-27protein level
8 16 2
2014-02-25protein level
5 17 2
2013-12-09protein level
5 13 2
2013-11-01protein level
5 13 2
2013-09-12protein level
4 13 2
2013-08-17protein level
4 13 2
2013-07-15protein level
4 4 1
2013-06-11protein level
4 4 1
2013-02-12protein level
4 2 2
2012-12-20protein level
4 2 2
2012-10-30protein level
4 3 2
2012-10-07protein level
4 3 1
2012-08-24protein level
4 2 1
2012-07-28protein level
3 2 1
2012-06-08protein level
3 7 1
2012-05-07protein level
3 7 1
2012-04-10protein level
3 7 1
2012-01-13protein level
3 6 1
2011-12-20protein level
3 6 1
2011-11-11protein level
3 6 1
2011-08-23protein level
3 6 1
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q96PM5-1
0 14 0 30089.7154
NX_Q96PM5-2
0 13 0 28963.2507
NX_Q96PM5-3
0 10 0 20705.4386
NX_Q96PM5-4
1 10 0 21681.8862
NX_Q96PM5-5
1 3 0 8487.792
NX_Q96PM5-6
1 13 0 27656.645
NX_Q96PM5-7
0 12 0 25319.5482
NX_Q96PM5-8
0 11 0 24193.0835
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-947779,EBI-5353084 KLHL41  
  .regulation of skeletal muscle cell differentiation
.regulation of myoblast proliferation
.skeletal muscle fiber development
  + 7 more...
.N/A .sarcoplasmic reticulum membrane
.Cul3-RING ubiquitin ligase complex
.M band
  + 7 more...
2 EBI-947779,EBI-3915012 HRG  
  .negative regulation of endothelial cell chemotaxis
.positive regulation of blood vessel remodeling
.negative regulation of vascular endothelial growth factor signaling pathway
  + 27 more...
.metal ion binding
.heparan sulfate proteoglycan binding
.heme binding
  + 6 more...
.blood microparticle
.extracellular exosome
.phagolysosome membrane
  + 4 more...
3 EBI-947779,EBI-366083 TP53  
  .positive regulation of intrinsic apoptotic signaling pathway
.positive regulation of reactive oxygen species metabolic process
.negative regulation of reactive oxygen species metabolic process
  + 99 more...
.protein phosphatase 2A binding
.chaperone binding
.protein N-terminus binding
  + 27 more...
.protein complex
.PML body
.nuclear matrix
  + 11 more...
4 EBI-947779,EBI-1237085 ARF4  
  .regulation of reactive oxygen species metabolic process
.response to axon injury
.positive regulation of transcription from RNA polymerase II promoter
  + 10 more...
.GTP binding
.epidermal growth factor receptor binding
.GTPase activity
.extracellular exosome
.ruffle membrane
.membrane
  + 2 more...
5 EBI-947779,EBI-397435 CALM2  
  .regulation of cell communication by electrical coupling involved in cardiac conduction
.regulation of high voltage-gated calcium channel activity
.positive regulation of protein serine/threonine kinase activity
  + 48 more...
.protein phosphatase activator activity
.ion channel binding
.protein serine/threonine kinase activator activity
  + 8 more...
.extracellular exosome
.vesicle
.growth cone
  + 10 more...
6 EBI-947779,EBI-722366 WDR74  
  .RNA metabolic process
.blastocyst formation
.N/A .nucleolus
.nucleus
7 EBI-947779,EBI-3943039 C19orf80  
  .triglyceride homeostasis
.regulation of lipoprotein metabolic process
.cell maturation
  + 5 more...
.hormone activity .extracellular region
8 EBI-947779,EBI-10173507 ADAMTSL4  
  .cellular protein metabolic process
.post-translational protein modification
.positive regulation of apoptotic process
  + 4 more...
.metalloendopeptidase activity
.protease binding
.endoplasmic reticulum lumen
.interstitial matrix
9 EBI-947779,EBI-945833 NOTCH2NL  
  .cell differentiation
.multicellular organismal development
.Notch signaling pathway
.calcium ion binding .cytoplasm
.extracellular region
10 EBI-947779,EBI-10257651 LIMS2  
  .positive regulation of integrin-mediated signaling pathway
.negative regulation of hepatocyte proliferation
.negative regulation of neural precursor cell proliferation
  + 4 more...
.zinc ion binding .focal adhesion
.plasma membrane
.cytosol
.nucleus
11 EBI-947779,EBI-1380492 UBASH3B  
  .negative regulation of platelet aggregation
.regulation of release of sequestered calcium ion into cytosol
.negative regulation of protein kinase activity
.protein tyrosine phosphatase activity .cytoplasm
.nucleus
12 EBI-947779,EBI-1538629 NKD2  
  .negative regulation of canonical Wnt signaling pathway
.positive regulation of establishment of protein localization to plasma membrane
.protein targeting to plasma membrane
  + 5 more...
.ubiquitin protein ligase binding
.growth factor binding
.calcium ion binding
.cell periphery
.cytoplasmic vesicle
.basolateral plasma membrane
.cytoplasmic membrane-bounded vesicle
13 EBI-947779,EBI-1044640 KRTAP9-2  
  .N/A .N/A .keratin filament
14 EBI-947779,EBI-10303490 SEMA4C  
  .semaphorin-plexin signaling pathway
.muscle cell differentiation
.positive regulation of stress-activated MAPK cascade
  + 3 more...
.receptor activity .postsynaptic membrane
.synaptic vesicle membrane
.cell junction
  + 3 more...
15 EBI-947779,EBI-3942989 AIG1  
  .N/A .N/A .integral component of membrane
16 EBI-947779,EBI-366978 NLK  
  .protein autophosphorylation
.intracellular signal transduction
.serine phosphorylation of STAT3 protein
  + 8 more...
.SH2 domain binding
.ubiquitin protein ligase binding
.transcription factor binding
  + 5 more...
.cytosol
.nucleoplasm
.nucleus
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
bladder33
blood24
bone41
bone marrow41
brain58
cervix103
connective tissue60
embryonic tissue14
eye28
heart44
intestine30
kidney56
liver19
lung41
lymph node66
mammary gland46
muscle28
nerve64
ovary19
parathyroid48
placenta38
prostate42
salivary gland49
skin42
spleen37
stomach10
testis39
thyroid21
trachea77
uterus38
vascular96
Health State
TissuesTPM*
normal37
breast (mammary gland) tumor32
cervical tumor28
chondrosarcoma36
colorectal tumor35
gastrointestinal tumor8
germ cell tumor45
glioma46
head and neck tumor14
kidney tumor14
leukemia52
liver tumor20
lung tumor9
non-neoplasia31
primitive neuroectodermal tumor of the CNS15
prostate cancer48
retinoblastoma21
skin tumor47
soft tissue/muscle tissue tumor87
uterine tumor11
Developmental Stage
TissuesTPM*
adult37
blastocyst16
fetus41
infant42
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue18.1
adrenal gland24.8
appendix20.7
bone marrow25.9
cerebral cortex27
colon30
duodenum21.8
esophagus25
gallbladder20.6
heart muscle44.2
kidney34.6
liver17.2
lung22.9
lymph node25.9
ovary27
pancreas10.9
placenta22
prostate20.8
salivary gland22.4
skin11.4
small intestine22.3
spleen26.7
stomach24.6
testis31.1
thyroid gland45
urinary bladder26.9
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*607680, gene) Zinc finger protein 363; ZNF363OMIM


#424, YPRC/BPRC, Industry-University Research Center, Yonsei Univ., Seodaemun-gu, Seoul, Korea, 120-749
Tel: +82-2-2123-6626, Fax: +82-2-393-6589
2014-2019 (C) Yonsei Proteome Research Center