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> Protein (NX_Q96PU4)
Protein (NX_Q96PU4)
Protein
Gene SymbolUHRF2 to neXtProt (NX_Q96PU4)
DescriptionE3 ubiquitin-protein ligase UHRF2
Chromosome9
Location9p24.1 (6413151 ~ 6507054) to Ensembl
Sequene Features : Isoforms 2, Variants 59, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.regulation of methylation-dependent chromatin silencing
.positive regulation of cell cycle arrest
.protein autoubiquitination
  + 7 more...
.ubiquitin protein ligase activity
.histone binding
.ligase activity
  + 3 more...
.nuclear heterochromatin
.nucleoplasm
.nucleus
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
2 59 8
2014-09-19protein level
2 52 8
2014-05-27protein level
2 52 9
2014-02-25protein level
2 51 9
2013-12-09protein level
2 40 9
2013-11-01protein level
2 39 5
2013-09-12protein level
2 39 5
2013-08-17protein level
2 39 5
2013-07-15protein level
2 23 3
2013-06-11protein level
2 23 3
2013-02-12protein level
2 7 2
2012-12-20protein level
2 6 2
2012-10-30protein level
2 9 2
2012-10-07protein level
2 9 2
2012-08-24protein level
2 9 2
2012-07-28protein level
2 9 2
2012-06-08protein level
2 12 2
2012-05-07protein level
2 11 2
2012-04-10protein level
2 11 2
2012-01-13protein level
2 9 1
2011-12-20protein level
2 9 1
2011-11-11protein level
2 9 1
2011-08-23protein level
2 9 1
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q96PU4-1
13 20 1 89927.6148
NX_Q96PU4-2
1 20 0 56040.8076
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-625304,EBI-366083 TP53  
  .positive regulation of intrinsic apoptotic signaling pathway
.positive regulation of reactive oxygen species metabolic process
.negative regulation of reactive oxygen species metabolic process
  + 99 more...
.protein phosphatase 2A binding
.chaperone binding
.protein N-terminus binding
  + 27 more...
.protein complex
.PML body
.nuclear matrix
  + 11 more...
2 EBI-625304,EBI-491274 RB1  
  .negative regulation of G1/S transition of mitotic cell cycle
.hepatocyte apoptotic process
.regulation of centromere complex assembly
  + 39 more...
.phosphoprotein binding
.androgen receptor binding
.identical protein binding
  + 7 more...
.Rb-E2F complex
.PML body
.SWI/SNF complex
  + 4 more...
3 EBI-625304,EBI-495332 CCNB1  
  .histone H3-S10 phosphorylation involved in chromosome condensation
.regulation of mitotic cell cycle spindle assembly checkpoint
.cellular response to hypoxia
  + 33 more...
.histone kinase activity
.protein kinase binding
.patched binding
.membrane
.cytosol
.centrosome
  + 5 more...
4 EBI-625304,EBI-457097 CCNA2  
  .cell division
.positive regulation of fibroblast proliferation
.positive regulation of transcription, DNA-templated
  + 11 more...
.N/A .cytoplasm
.nucleoplasm
.nucleus
  + 2 more...
5 EBI-625304,EBI-375001 CCND1  
  .negative regulation of cell cycle arrest
.response to UV-A
.mammary gland alveolus development
  + 34 more...
.proline-rich region binding
.histone deacetylase binding
.protein kinase binding
  + 5 more...
.transcriptional repressor complex
.membrane
.tight junction
  + 5 more...
6 EBI-625304,EBI-519526 CCNE1  
  .regulation of cell cycle
.cell division
.positive regulation of transcription, DNA-templated
  + 7 more...
.androgen receptor binding
.cyclin-dependent protein serine/threonine kinase regulator activity
.kinase activity
.transcription coactivator activity
.cytosol
.nucleoplasm
.nucleus
.cyclin-dependent protein kinase holoenzyme complex
7 EBI-625304,EBI-375096 CDK2  
  .cellular response to nitric oxide
.regulation of gene silencing
.regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
  + 20 more...
.metal ion binding
.cyclin binding
.ATP binding
.cyclin-dependent protein serine/threonine kinase activity
.Cajal body
.cytosol
.centrosome
  + 10 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
bladder66
blood24
bone55
bone marrow123
brain27
cervix20
connective tissue53
ear62
embryonic tissue42
eye23
heart11
intestine25
kidney23
liver19
lung26
lymph22
lymph node100
mammary gland6
mouth30
muscle28
ovary9
pancreas32
pharynx24
placenta7
prostate31
skin28
spleen18
stomach10
testis55
thymus37
thyroid21
tonsil58
trachea57
uterus81
vascular96
Health State
TissuesTPM*
normal32
bladder carcinoma113
cervical tumor28
chondrosarcoma96
colorectal tumor26
gastrointestinal tumor8
germ cell tumor30
glioma9
head and neck tumor22
kidney tumor14
leukemia63
liver tumor20
lung tumor9
lymphoma69
non-neoplasia20
ovarian tumor13
primitive neuroectodermal tumor of the CNS7
prostate cancer19
retinoblastoma21
skin tumor23
soft tissue/muscle tissue tumor55
uterine tumor77
Developmental Stage
TissuesTPM*
adult30
embryoid body42
blastocyst32
fetus30
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue13.8
adrenal gland17.9
appendix31
bone marrow68.8
cerebral cortex12.9
colon15.6
duodenum16.5
esophagus14.2
gallbladder21.1
heart muscle8.8
kidney12.6
liver8.4
lung19
lymph node49.1
ovary26.3
pancreas8.8
placenta19.4
prostate28.4
salivary gland11.7
skin18.7
small intestine19.2
spleen30.5
stomach19.5
testis22
thyroid gland16.2
urinary bladder22.5
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected


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