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> Protein (NX_Q96PU5)
Protein (NX_Q96PU5)
Protein
Gene SymbolNEDD4L to neXtProt (NX_Q96PU5)
DescriptionE3 ubiquitin-protein ligase NEDD4-like
Chromosome18
Location18q21.31 (55711599 ~ 56068772) to Ensembl
Sequene Features : Isoforms 8, Variants 90, PTMs 19 to neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.positive regulation of caveolin-mediated endocytosis
.positive regulation of cation channel activity
.regulation of tight junction assembly
  + 39 more...
.ion channel binding
.sodium channel inhibitor activity
.potassium channel inhibitor activity
  + 4 more...
.extracellular exosome
.cytosol
.cytoplasm
  + 3 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
8 90 19
2014-09-19protein level
8 68 19
2014-05-27protein level
8 68 19
2014-02-25protein level
8 68 19
2013-12-09protein level
8 53 19
2013-11-01protein level
8 53 15
2013-09-12protein level
8 53 15
2013-08-17protein level
8 53 15
2013-07-15protein level
8 31 15
2013-06-11protein level
8 31 15
2013-02-12protein level
8 11 108
2012-12-20protein level
8 12 105
2012-10-30protein level
8 16 108
2012-10-07protein level
8 16 15
2012-08-24protein level
9 15 15
2012-07-28protein level
9 15 15
2012-06-08protein level
9 21 15
2012-05-07protein level
8 12 15
2012-04-10protein level
8 12 15
2012-01-13protein level
8 13 15
2011-12-20protein level
8 13 15
2011-11-11protein level
8 15 14
2011-08-23protein level
8 15 14
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q96PU5-1
0 41 7 111861.5003
NX_Q96PU5-2
1 37 7 104856.0698
NX_Q96PU5-3
1 36 7 100688.9512
NX_Q96PU5-4
0 35 6 98119.4449
NX_Q96PU5-5
0 40 7 109952.5769
NX_Q96PU5-6
0 40 7 109335.3825
NX_Q96PU5-7
0 41 7 111244.3059
NX_Q96PU5-9
0 34 6 96210.5215
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-717962,EBI-724310 DAZAP2  
  .N/A .WW domain binding .cytoplasm
.nucleus
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adrenal gland121
ascites25
bladder66
blood32
bone41
bone marrow20
brain96
cervix20
connective tissue67
embryonic tissue61
esophagus49
eye119
heart100
intestine73
kidney123
larynx127
liver151
lung89
lymph node33
mammary gland72
mouth120
muscle65
ovary19
pancreas46
pharynx24
pituitary gland60
placenta56
prostate211
salivary gland148
skin170
spleen18
stomach20
testis22
thyroid64
trachea135
umbilical cord72
uterus25
vascular19
Health State
TissuesTPM*
normal99
bladder carcinoma227
breast (mammary gland) tumor42
cervical tumor28
chondrosarcoma72
colorectal tumor88
esophageal tumor57
gastrointestinal tumor25
germ cell tumor49
glioma83
head and neck tumor104
kidney tumor14
leukemia42
liver tumor249
lung tumor48
non-neoplasia10
ovarian tumor13
pancreatic tumor38
primitive neuroectodermal tumor of the CNS7
prostate cancer154
retinoblastoma21
skin tumor223
soft tissue/muscle tissue tumor47
uterine tumor66
Developmental Stage
TissuesTPM*
adult81
embryoid body42
blastocyst81
neonate32
fetus181
juvenile71
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue8.9
adrenal gland9.8
appendix8.5
bone marrow8.1
cerebral cortex23.7
colon47.2
duodenum16.2
esophagus15
gallbladder19.8
heart muscle22.9
kidney53
liver8.4
lung45.1
lymph node5.2
ovary8.6
pancreas36.5
placenta19.9
prostate52.4
salivary gland27.1
skin4.6
small intestine23.5
spleen5.3
stomach35.4
testis10.3
thyroid gland26.9
urinary bladder33.5
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*606384, gene) Ubiquitin protein ligase nedd4-like; NEDD4LOMIM


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