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> Protein (NX_Q96QH2)
Protein (NX_Q96QH2)
Protein
Gene SymbolPRAM1 to neXtProt (NX_Q96QH2)
DescriptionPML-RARA-regulated adapter molecule 1
Chromosome19
Location19p13.2 (8554940 ~ 8567996) to Ensembl
Sequene Features : Isoforms 2, Variants 89, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.regulation of neutrophil degranulation
.integrin-mediated signaling pathway
.lipid binding .N/A
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
2 89 4
2014-09-19protein level
2 64 4
2014-05-27protein level
2 64 4
2014-02-25protein level
2 64 4
2013-12-09protein level
2 47 4
2013-11-01protein level
2 47 4
2013-09-12protein level
2 47 5
2013-08-17protein level
2 47 5
2013-07-15protein level
2 28 5
2013-06-11protein level
2 28 5
2013-02-12protein level
2 18 2
2012-12-20protein level
2 17 2
2012-10-30protein level
2 21 2
2012-10-07protein level
2 21 1
2012-08-24protein level
2 18 1
2012-07-28protein level
2 16 1
2012-06-08protein level
2 6 1
2012-05-07protein level
2 6 1
2012-04-10protein level
2 6 1
2012-01-13protein level
2 6 1
2011-12-20protein level
2 6 1
2011-11-11protein level
2 6 1
2011-08-23protein level
2 6 1
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q96QH2-1
1 44 0 79195.6781
NX_Q96QH2-2
1 40 0 73922.7777
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-2860740,EBI-719493 TRIM27  
  .negative regulation of viral release from host cell
.negative regulation of interleukin-2 secretion
.negative regulation of calcium ion import
  + 17 more...
.metal ion binding
.ligase activity
.zinc ion binding
  + 4 more...
.nuclear membrane
.PML body
.membrane
  + 6 more...
2 EBI-2860740,EBI-740459 FXR2  
  .negative regulation of translation
.positive regulation of defense response to virus by host
.poly(A) RNA binding
.identical protein binding
.mRNA binding
.RNA binding
.extracellular exosome
.cytosolic large ribosomal subunit
.membrane
  + 3 more...
3 EBI-2860740,EBI-2808286 CCDC57  
  .N/A .N/A .N/A
4 EBI-2860740,EBI-10171697 KRT40  
  .N/A .structural molecule activity .intermediate filament
5 EBI-2860740,EBI-2477305 SKAP1  
  .T cell receptor signaling pathway
.positive regulation of transcription from RNA polymerase II promoter
.positive regulation of transcription, DNA-templated
.positive regulation of signal transduction
.SH2 domain binding
.protein phosphatase binding
.protein kinase binding
  + 2 more...
.cell-cell junction
.plasma membrane
.cytoplasm
.nucleus
6 EBI-2860740,EBI-724829 RNF32  
  .N/A .zinc ion binding .aggresome
.endosome
7 EBI-2860740,EBI-743598 ABI2  
  .positive regulation of Arp2/3 complex-mediated actin nucleation
.peptidyl-tyrosine phosphorylation
.Rac protein signal transduction
  + 5 more...
.proline-rich region binding
.protein complex binding
.ubiquitin protein ligase binding
  + 4 more...
.SCAR complex
.filopodium
.lamellipodium
  + 3 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
blood122
bone13
bone marrow20
brain5
connective tissue6
lung8
prostate5
spleen18
thymus25
thyroid21
Health State
TissuesTPM*
normal7
glioma9
head and neck tumor7
leukemia84
non-neoplasia10
prostate cancer9
Developmental Stage
TissuesTPM*
adult7
neonate32
fetus3
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue1.5
appendix8.2
bone marrow59.1
cerebral cortex1.3
duodenum1.6
gallbladder1.7
liver1.3
lung6.6
lymph node1.1
placenta1.2
prostate1.7
skin1.7
small intestine2.2
spleen8
stomach1
testis1
urinary bladder1.6
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*606466, gene) Pml-rara target gene encoding an adaptor molecule 1; PRAM1OMIM


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