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> Protein (NX_Q96R06)
Protein (NX_Q96R06)
Protein
Gene SymbolSPAG5 to neXtProt (NX_Q96R06)
DescriptionSperm-associated antigen 5
Chromosome17
Location17q11.2 (26904588 ~ 26926297) to Ensembl
Sequene Features : Isoforms 1, Variants 143, PTMs 24 to neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.regulation of attachment of spindle microtubules to kinetochore
.cell division
.chromosome segregation
  + 2 more...
.N/A .mitotic spindle
.microtubule plus-end
.midbody
  + 7 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
1 143 24
2014-09-19protein level
1 114 24
2014-05-27protein level
1 114 24
2014-02-25protein level
1 112 20
2013-12-09protein level
1 86 20
2013-11-01protein level
1 83 19
2013-09-12protein level
1 83 19
2013-08-17protein level
1 83 19
2013-07-15protein level
1 59 16
2013-06-11protein level
1 59 16
2013-02-12protein level
1 34 24
2012-12-20protein level
1 31 24
2012-10-30protein level
1 43 24
2012-10-07protein level
1 43 24
2012-08-24protein level
1 38 24
2012-07-28protein level
1 36 24
2012-06-08protein level
1 42 24
2012-05-07protein level
1 40 24
2012-04-10protein level
1 40 24
2012-01-13protein level
1 15 24
2011-12-20protein level
1 15 24
2011-11-11protein level
1 15 22
2011-08-23protein level
1 15 22
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q96R06-1
58 0 0 134337.4151
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-413317,EBI-8646694 DCX  
  .dendrite morphogenesis
.axon extension
.protein autophosphorylation
  + 8 more...
.protein kinase binding
.calcium-dependent protein serine/threonine kinase activity
.microtubule binding
  + 2 more...
.neuron projection
.microtubule associated complex
.microtubule
  + 4 more...
2 EBI-413317,EBI-398610 EIF4E2  
  .cytokine-mediated signaling pathway
.negative regulation of translation
.in utero embryonic development
.poly(A) RNA binding
.ubiquitin protein ligase binding
.translation factor activity, RNA binding
  + 2 more...
.mRNA cap binding complex
.cytosol
3 EBI-413317,EBI-359527 POLR2L  
  .positive regulation of viral transcription
.negative regulation of gene expression, epigenetic
.innate immune response
  + 23 more...
.zinc ion binding
.DNA-directed RNA polymerase activity
.DNA binding
.cytosol
.DNA-directed RNA polymerase I complex
.DNA-directed RNA polymerase III complex
  + 3 more...
4 EBI-413317,EBI-10181260 GOLGA8F  
  .N/A .N/A .Golgi apparatus
5 EBI-413317,EBI-10181276 GOLGA8DP  
  .N/A .N/A .Golgi apparatus
6 EBI-413317,EBI-740767 ZC2HC1C  
  .N/A .metal ion binding .N/A
7 EBI-413317,EBI-10244848 SNAP47  
  .long-term synaptic potentiation
.synaptic vesicle fusion to presynaptic membrane
.synaptic vesicle priming
.syntaxin binding
.SNAP receptor activity
.perinuclear region of cytoplasm
.neuronal cell body
.SNARE complex
  + 3 more...
8 EBI-413317,EBI-6447954 TTC23  
  .N/A .N/A .N/A
9 EBI-413317,EBI-913476 CLASP1  
  .cell division
.establishment of spindle orientation
.microtubule anchoring
  + 13 more...
.microtubule plus-end binding
.kinetochore binding
.microtubule binding
.extracellular exosome
.centrosomal corona
.cortical microtubule cytoskeleton
  + 10 more...
10 EBI-413317,EBI-10260504 CDC20B  
  .N/A .N/A .N/A
11 EBI-413317,EBI-1567928 RPTOR  
  .regulation of cellular response to heat
.positive regulation of protein serine/threonine kinase activity
.cellular response to amino acid stimulus
  + 12 more...
.14-3-3 protein binding
.protein complex binding
.protein kinase binding
  + 4 more...
.intracellular membrane-bounded organelle
.neuronal cell body
.TORC1 complex
  + 6 more...
12 EBI-413317,EBI-10274069 LGALS14  
  .positive regulation of T cell apoptotic process
.apoptotic process
.carbohydrate binding .nucleus
13 EBI-413317,EBI-10175300 CCHCR1  
  .cell differentiation
.multicellular organismal development
.protein export from nucleus
.N/A .centriole
.cytoplasm
.nucleus
14 EBI-413317,EBI-455078 SMARCE1  
  .negative regulation of transcription, DNA-templated
.ATP-dependent chromatin remodeling
.metabolic process
  + 4 more...
.protein N-terminus binding
.ligand-dependent nuclear receptor binding
.N-acetyltransferase activity
  + 4 more...
.nBAF complex
.npBAF complex
.protein complex
  + 6 more...
15 EBI-413317,EBI-2514791 HAUS1  
  .cell division
.centrosome organization
.spindle assembly
.mitotic nuclear division
.N/A .HAUS complex
.microtubule
.centrosome
  + 2 more...
16 EBI-413317,EBI-719955 LINGO1  
  .negative regulation of axonogenesis
.regulation of axonogenesis
.negative regulation of oligodendrocyte differentiation
  + 4 more...
.N/A .integral component of membrane
.plasma membrane
17 EBI-413317,EBI-740773 RBM41  
  .N/A .RNA binding
.nucleotide binding
.N/A
18 EBI-413317,EBI-2682299 ZMAT2  
  .N/A .zinc ion binding
.DNA binding
.nucleus
19 EBI-413317,EBI-747035 SH2D4A  
  .negative regulation of phosphatase activity .phosphatase binding .cytoplasm
20 EBI-413317,EBI-740282 FBXO28  
  .N/A .N/A .N/A
21 EBI-413317,EBI-8643161 C1orf109  
  .N/A .N/A .N/A
22 EBI-413317,EBI-743375 CHCHD3  
  .mitochondrial fusion
.inner mitochondrial membrane organization
.negative regulation of transcription from RNA polymerase II promoter
.protein complex scaffold
.phosphatase binding
.RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
.extracellular exosome
.mitochondrial inner membrane
.mitochondrion
  + 2 more...
23 EBI-413317,EBI-10187270 AMOTL2  
  .hippo signaling
.Wnt signaling pathway
.N/A .recycling endosome
.cytoplasmic vesicle
.apical plasma membrane
  + 2 more...
24 EBI-413317,EBI-374840 ORC6  
  .DNA-dependent DNA replication
.DNA replication
.mitotic cell cycle
.G1/S transition of mitotic cell cycle
.DNA binding .membrane
.plasma membrane
.nuclear origin of replication recognition complex
  + 3 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adrenal gland91
ascites100
blood49
bone97
bone marrow61
brain22
cervix247
connective tissue6
embryonic tissue201
eye86
intestine51
kidney23
liver34
lung77
lymph112
lymph node11
mammary gland152
mouth120
muscle56
ovary59
pancreas32
placenta7
prostate26
salivary gland98
skin166
stomach10
testis381
thymus163
thyroid42
umbilical cord290
uterus51
vascular38
Health State
TissuesTPM*
normal37
adrenal tumor237
bladder carcinoma56
breast (mammary gland) tumor225
cervical tumor144
chondrosarcoma60
colorectal tumor62
gastrointestinal tumor67
germ cell tumor91
glioma83
head and neck tumor74
kidney tumor72
leukemia74
liver tumor62
lung tumor194
lymphoma96
non-neoplasia20
ovarian tumor65
pancreatic tumor47
primitive neuroectodermal tumor of the CNS39
prostate cancer57
retinoblastoma279
skin tumor239
soft tissue/muscle tissue tumor87
uterine tumor77
Developmental Stage
TissuesTPM*
adult43
embryoid body114
blastocyst406
neonate225
fetus52
juvenile125
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue3.6
adrenal gland4.1
appendix12.7
bone marrow45
cerebral cortex4
colon9.2
duodenum9.9
esophagus4.1
gallbladder3
heart muscle1.2
kidney29.5
liver5.2
lung3.1
lymph node18.6
ovary3
pancreas1.1
placenta6.9
prostate3
salivary gland1.6
skin7.7
small intestine12.1
spleen5.1
stomach5.2
testis69.4
thyroid gland6.1
urinary bladder5.3
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected


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