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> Protein (NX_Q96RN5)
Protein (NX_Q96RN5)
Protein
Gene SymbolMED15 to neXtProt (NX_Q96RN5)
DescriptionMediator of RNA polymerase II transcription subunit 15
Chromosome22
Location22q11.21 (20850200 ~ 20941919) to Ensembl
Sequene Features : Isoforms 3, Variants 77, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.stem cell maintenance
.gene expression
.transcription initiation from RNA polymerase II promoter
.RNA polymerase II transcription cofactor activity .mediator complex
.membrane
.cytoplasm
  + 2 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
3 77 2
2014-09-19protein level
3 59 2
2014-05-27protein level
3 59 2
2014-02-25protein level
3 53 2
2013-12-09protein level
3 36 2
2013-11-01protein level
3 35 2
2013-09-12protein level
3 35 2
2013-08-17protein level
3 35 2
2013-07-15protein level
3 17 2
2013-06-11protein level
3 17 2
2013-02-12protein level
3 8 9
2012-12-20protein level
3 9 9
2012-10-30protein level
3 9 9
2012-10-07protein level
3 9 3
2012-08-24protein level
3 9 3
2012-07-28protein level
3 9 3
2012-06-08protein level
3 24 3
2012-05-07protein level
3 21 3
2012-04-10protein level
3 21 3
2012-01-13protein level
3 25 3
2011-12-20protein level
3 25 3
2011-11-11protein level
3 25 3
2011-08-23protein level
3 25 2
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q96RN5-1
3 19 0 86698.7091
NX_Q96RN5-2
0 20 0 82528.556
NX_Q96RN5-3
1 18 0 75879.4333
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-394506,EBI-394489 MED14  
  .positive regulation of transcription from RNA polymerase II promoter
.positive regulation of transcription, DNA-templated
.androgen receptor signaling pathway
  + 5 more...
.thyroid hormone receptor binding
.vitamin D receptor binding
.ligand-dependent nuclear receptor transcription coactivator activity
  + 4 more...
.mediator complex
.membrane
.nucleoplasm
.nucleus
2 EBI-394506,EBI-948328 SREBF1  
  .regulation of protein targeting to mitochondrion
.regulation of mitochondrion degradation
.cellular response to fatty acid
  + 26 more...
.sequence-specific DNA binding
.sterol response element binding
.sequence-specific DNA binding transcription factor activity
  + 2 more...
.protein complex
.integral component of membrane
.ER to Golgi transport vesicle membrane
  + 8 more...
3 EBI-394506,EBI-466029 HTT  
  .negative regulation of extrinsic apoptotic signaling pathway
.iron ion homeostasis
.L-glutamate import
  + 38 more...
.diazepam binding
.beta-tubulin binding
.dynein intermediate chain binding
  + 6 more...
.protein complex
.cytoplasmic vesicle membrane
.dendrite
  + 11 more...
4 EBI-394506,EBI-394558 MED25  
  .positive regulation of mediator complex assembly
.positive regulation of cell cycle arrest
.negative regulation of fibroblast proliferation
  + 5 more...
.retinoid X receptor binding
.retinoic acid receptor binding
.transcription factor binding
.nucleoplasm
5 EBI-394506,EBI-851809 TRIM11  
  .negative regulation of viral release from host cell
.defense response to virus
.negative regulation of neurogenesis
  + 5 more...
.ligase activity
.zinc ion binding
.ubiquitin-protein transferase activity
.cytoplasm
.nucleus
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adrenal gland121
ascites351
bladder33
blood188
bone181
bone marrow123
brain116
connective tissue100
embryonic tissue56
esophagus99
eye100
heart67
intestine112
kidney85
larynx426
liver73
lung167
lymph45
lymph node111
mammary gland46
mouth196
muscle28
nerve128
ovary49
pancreas271
pituitary gland181
placenta134
prostate84
salivary gland49
skin104
spleen149
stomach114
testis119
thymus263
thyroid171
tonsil235
trachea231
umbilical cord145
uterus94
vascular38
Health State
TissuesTPM*
normal100
bladder carcinoma56
breast (mammary gland) tumor21
chondrosarcoma156
colorectal tumor106
esophageal tumor115
gastrointestinal tumor202
germ cell tumor155
glioma102
head and neck tumor224
kidney tumor188
leukemia264
liver tumor124
lung tumor155
lymphoma110
non-neoplasia124
ovarian tumor26
pancreatic tumor419
primitive neuroectodermal tumor of the CNS62
prostate cancer96
retinoblastoma86
skin tumor103
soft tissue/muscle tissue tumor71
uterine tumor55
Developmental Stage
TissuesTPM*
adult117
embryoid body57
blastocyst97
neonate96
fetus84
infant127
juvenile161
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue25.6
adrenal gland24.9
appendix33.9
bone marrow44.9
cerebral cortex19.4
colon18.5
duodenum28
esophagus19.7
gallbladder29.4
heart muscle15.3
kidney15.2
liver6.4
lung32.3
lymph node38.9
ovary19.3
pancreas11.8
placenta29.6
prostate22.1
salivary gland17.9
skin28.8
small intestine27.7
spleen43.8
stomach25.8
testis28.4
thyroid gland16.4
urinary bladder23.1
Tissues
TissuesExpression level
adrenal glandHigh
appendixHigh
bone marrowHigh
breastHigh
bronchusHigh
cerebellumHigh
cerebral cortexMedium
cervix, uterineHigh
colonHigh
duodenumHigh
endometrium 1High
endometrium 2Medium
epididymisHigh
esophagusHigh
fallopian tubeHigh
gallbladderHigh
heart muscleHigh
hippocampusMedium
kidneyMedium
lateral ventricleHigh
liverMedium
lungHigh
lymph nodeHigh
nasopharynxHigh
oral mucosaHigh
ovaryMedium
pancreasHigh
parathyroid glandHigh
placentaHigh
prostateMedium
rectumHigh
salivary glandLow
seminal vesicleHigh
skeletal muscleMedium
skin 1High
small intestineHigh
smooth muscleMedium
soft tissue 1High
soft tissue 2High
spleenHigh
stomach 1High
stomach 2High
testisHigh
thyroid glandHigh
tonsilHigh
urinary bladderHigh
vaginaHigh
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*607372, gene) Mediator complex subunit 15; MED15OMIM


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