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> Protein (NX_Q96RU7)
Protein (NX_Q96RU7)
Protein
Gene SymbolTRIB3 to neXtProt (NX_Q96RU7)
DescriptionTribbles homolog 3
Chromosome20
Location20p13 (361261 ~ 378203) to Ensembl
Sequene Features : Isoforms 1, Variants 74, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
.positive regulation of ubiquitin-protein transferase activity
.phosphatidylinositol-mediated signaling
  + 21 more...
.ubiquitin-protein transferase regulator activity
.ubiquitin protein ligase binding
.mitogen-activated protein kinase kinase binding
  + 5 more...
.plasma membrane
.cytosol
.nucleoplasm
.nucleus
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
1 74 1
2014-09-19protein level
1 62 1
2014-05-27protein level
1 62 1
2014-02-25protein level
1 62 1
2013-12-09protein level
1 46 1
2013-11-01protein level
1 45 1
2013-09-12protein level
1 45 1
2013-08-17protein level
1 45 1
2013-07-15protein level
1 37 1
2013-06-11protein level
1 37 1
2013-02-12protein level
1 28 0
2012-12-20protein level
1 28 0
2012-10-30protein level
1 28 0
2012-10-07protein level
1 28 0
2012-08-24protein level
1 27 0
2012-07-28protein level
1 27 0
2012-06-08protein level
1 31 0
2012-05-07protein level
1 29 0
2012-04-10protein level
1 29 0
2012-01-13protein level
1 18 0
2011-12-20protein level
1 18 0
2011-11-11protein level
1 18 0
2011-08-23protein level
1 18 0
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q96RU7-1
18 0 0 39552.4657
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-492476,EBI-351098 PRMT5  
  .histone H4-R3 methylation
.endothelial cell activation
.peptidyl-arginine N-methylation
  + 12 more...
.protein heterodimerization activity
.ribonucleoprotein complex binding
.protein-arginine omega-N symmetric methyltransferase activity
  + 5 more...
.methylosome
.cytosol
.cytoplasm
  + 2 more...
2 EBI-492476,EBI-492498 ATF4  
  .positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress
.negative regulation of oxidative stress-induced neuron death
.intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
  + 21 more...
.protein heterodimerization activity
.transcription regulatory region DNA binding
.sequence-specific DNA binding
  + 9 more...
.CHOP-ATF4 complex
.ATF1-ATF4 transcription factor complex
.ATF4-CREB1 transcription factor complex
  + 8 more...
3 EBI-492476,EBI-1050213 RPGRIP1  
  .retina development in camera-type eye
.response to stimulus
.eye photoreceptor cell development
.visual perception
.N/A .photoreceptor connecting cilium
.axoneme
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adrenal gland30
ascites175
blood73
bone69
bone marrow184
brain11
cervix556
connective tissue6
embryonic tissue28
esophagus248
eye43
intestine103
kidney99
liver34
lung95
mammary gland112
mouth15
muscle235
ovary39
pancreas28
placenta31
prostate52
skin128
spleen18
stomach104
thymus12
thyroid150
tonsil352
uterus21
vascular19
Health State
TissuesTPM*
normal16
adrenal tumor79
breast (mammary gland) tumor139
cervical tumor608
chondrosarcoma48
colorectal tumor151
esophageal tumor289
gastrointestinal tumor109
germ cell tumor45
glioma65
head and neck tumor59
kidney tumor188
leukemia137
liver tumor52
lung tumor272
lymphoma124
non-neoplasia10
ovarian tumor26
pancreatic tumor38
primitive neuroectodermal tumor of the CNS118
prostate cancer86
skin tumor191
soft tissue/muscle tissue tumor215
uterine tumor33
Developmental Stage
TissuesTPM*
adult49
embryoid body42
fetus19
juvenile161
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue3.8
adrenal gland3
appendix3.4
bone marrow8.1
cerebral cortex2.5
colon2
duodenum1
esophagus5.4
gallbladder2.3
kidney1.5
liver11.4
lung6.1
lymph node5.2
ovary1.9
pancreas3.7
placenta6.8
prostate5.2
salivary gland5.1
skin5.3
small intestine1
spleen6.7
stomach2.2
testis1.1
thyroid gland34.9
urinary bladder3.2
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*607898, gene) Tribbles, drosophila, homolog of, 3; TRIB3OMIM


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